Evaluating the Biological Activity and Effects on Human Health of Fish Oil and Its Omega-3 Fatty Acids

2008 ◽  
pp. 195-214 ◽  
Author(s):  
Adrian S. Dobs ◽  
Daniel Edelstein
Keyword(s):  
Fatty Acids ◽  
Biological Activity ◽  
Fish Oil ◽  
Human Health ◽  
Omega 3 Fatty Acids ◽  
Omega 3

Fish oil plus wheat germ oil have no prominent effect on homocysteine levels and nutritional indices in hemodialysis patients

2019 ◽  
pp. 1-7
Author(s):  
Hadeer Zakaria ◽  
Tarek M. Mostafa ◽  
Gamal A. El-Azab ◽  
Nagy AH Sayed-Ahmed
Keyword(s):  
Fatty Acids ◽  
Vitamin E ◽  
Fish Oil ◽  
Wheat Germ ◽  
Hemodialysis Patients ◽  
Nutritional Indices ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Wheat Germ Oil ◽  
Serum Homocysteine

Abstract. Background: Elevated homocysteine levels and malnutrition are frequently detected in hemodialysis patients and are believed to exacerbate cardiovascular comorbidities. Omega-3 fatty acids have been postulated to lower homocysteine levels by up-regulating metabolic enzymes and improving substrate availability for homocysteine degradation. Additionally, it has been suggested that prevention of folate depletion by vitamin E consumption decreases homocysteine levels. However, data on the effect of omega-3 fatty acids and/or vitamin E on homocysteine levels and nutritional status have been inconclusive. Therefore, this study was planned to examine the effect of combined supplementation of fish oil, as a source of omega-3 fatty acids, with wheat germ oil, as a source of vitamin E, on homocysteine and nutritional indices in hemodialysis patients. Methods: This study was a randomized, double-blind, placebo-controlled trial. Forty-six hemodialysis patients were randomly assigned to two equally-sized groups; a supplemented group who received 3000 mg/day of fish oil [1053 mg omega-3 fatty acids] plus 300 mg/day of wheat germ oil [0.765 mg vitamin E], and a matched placebo group who received placebo capsules for 4 months. Serum homocysteine and different nutritional indices were measured before and after the intervention. Results: Twenty patients in each group completed the study. At the end of the study, there were no significant changes in homocysteine levels and in the nutritional indices neither in the supplemented nor in the placebo-control groups (p > 0.05). Conclusions: Fish oil and wheat germ oil combination did not produce significant effects on serum homocysteine levels and nutritional indices of hemodialysis patients.

scholarly journals Enzyme-Assisted Extraction of Fish Oil from Whole Fish and by-Products of Baltic Herring (Clupea harengus membras)

Foods ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1811
Author(s):  
Ella Aitta ◽  
Alexis Marsol-Vall ◽  
Annelie Damerau ◽  
Baoru Yang
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Fish Oil ◽  
Crude Oil ◽  
Proteolytic Enzymes ◽  
Clupea Harengus ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Baltic Herring ◽  
By Products

Baltic herring (Clupea harengus membras) is one of the most abundant commercially caught fish species from the Baltic Sea. Despite the high content of fat and omega-3 fatty acids, the consumption of Baltic herring has decreased dramatically over the last four decades, mostly due to the small sizes and difficulty in processing. At the same time there is an increasing global demand for fish and fish oil rich in omega-3 fatty acids. This study aimed to investigate enzyme-assisted oil extraction as an environmentally friendly process for valorizing the underutilized fish species and by-products to high quality fish oil for human consumption. Three different commercially available proteolytic enzymes (Alcalase®, Neutrase® and Protamex®) and two treatment times (35 and 70 min) were investigated in the extraction of fish oil from whole fish and by-products from filleting of Baltic herring. The oil quality and stability were studied with peroxide- and p-anisidine value analyses, fatty acid analysis with GC-FID, and volatile compounds with HS-SPME-GC-MS. Overall, longer extraction times led to better oil yields but also increased oxidation of the oil. For whole fish, the highest oil yields were from the 70-min extractions with Neutrase and Protamex. Protamex extraction with 35 min resulted in the best fatty acid composition with the highest content of eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3) but also increased oxidation compared to treatment with other enzymes. For by-products, the highest oil yield was obtained from the 70-min extraction with Protamex without significant differences in EPA and DHA contents among the oils extracted with different enzymes. Oxidation was lowest in the oil produced with 35-min treatment using Neutrase and Protamex. This study showed the potential of using proteolytic enzymes in the extraction of crude oil from Baltic herring and its by-products. However, further research is needed to optimize enzymatic processing of Baltic herring and its by-products to improve yield and quality of crude oil.

Cardioprotective effects of omega 3 fatty acids from fish oil and it enhances autoimmunity in porcine cardiac myosin-induced myocarditis in the rat model

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ling-Yan Li ◽  
Xu Wang ◽  
Ting-Chuan Zhang ◽  
Zong-Jun Liu ◽  
Jun-Qing Gao
Keyword(s):  
Fatty Acids ◽  
Fish Oil ◽  
Inflammatory Cells ◽  
Omega 3 Fatty Acids ◽  
Cardiac Myosin ◽  
Omega 3 ◽  
Autoimmune Myocarditis ◽  
Tuna Fish ◽  
Fame Analysis ◽  
Total Fatty Acids

Abstract This experiment proposed to investigate the efficiency of omega 3 fatty acids from fish that improves autoimmune against myocarditis in the rat. Fish oil was extracted from fresh Tuna fish and performed FAME analysis and mice bioassay. The autoimmune myocarditis was induced by subcutaneous injection of porcine cardiac myosin (PCM) into the footpads of rats on the first and seventh day. Rats were dissected on the 21st day to analyze the histopathological, hemodynamic, echocardiographic factors, and immunohistochemistry expressions. In the study, 73.90% of total fatty acids were recorded. Histological analysis revealed that omega 3 fatty acids administrated groups showed tremendous development in the multifocal myocardia hyaline degeneration and necrosis with inflammatory changes. Moreover, omega 3 fatty acids inhabited the expressions of inflammatory cells (CD4, CD8 and CD11b) and suppressed the level of NF-κB. The echocardiographic factors such as heartbeat, SBP, DBP, levels of LVDs, LVDd, LVPW percentage of LVFS, EF, expression levels of inflammatory cytokines (TNF, IL-1β, IFN-ɤ, IL-2, and IL-6) also significantly suppressed by omega 3 fatty acids. Hence, the present study proved that consuming fatty acid-enriched fish might be a successful therapy for improving the inflammatory profile, regenerates the heart tissues, and controlled the production of inflammatory cells.

scholarly journals Fish oil and omega-3 fatty acids in cardiovascular disease: do they really work?

2011 ◽  
Vol 33 (4) ◽  
pp. 436-443 ◽  
Author(s):  
D. Kromhout ◽  
S. Yasuda ◽  
J. M. Geleijnse ◽  
H. Shimokawa
Keyword(s):  
Cardiovascular Disease ◽  
Fatty Acids ◽  
Fish Oil ◽  
Omega 3 Fatty Acids ◽  
Omega 3

Omega-3 Levels and Nicotine Dependence: A Cross-Sectional Study and Clinical Trial

2015 ◽  
Vol 22 (3) ◽  
pp. 153-162 ◽  
Author(s):  
Juçara X. Zaparoli ◽  
Eduardo K. Sugawara ◽  
Altay A.L. de Souza ◽  
Sérgio Tufik ◽  
José Carlos F. Galduróz
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Fish Oil ◽  
Nicotine Dependence ◽  
Cross Sectional Study ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Double Blind ◽  
Cross Sectional ◽  
Omega 3 Fatty Acid

Background: High oxidative stress, which is caused by smoking, can alter omega-3 fatty acid concentrations. Since omega-3 fatty acids play a role in dopaminergic neurotransmission related to dependence, it is important to understand their effects on nicotine dependence. Methods: This research comprised 2 studies. The first one consisted of a cross-sectional evaluation, in which the levels of the most important omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), were compared between smokers and non-smokers in a sample of 171 individuals; of them, 120 were smokers and 51 were non-smokers. The other study was a clinical, double-blind, randomized, placebo controlled, in which 63 smokers received daily treatment with capsules of fish oil (a source of omega-3/3 g/day) or mineral oil (used as placebo, also 3 g/day), taken 3 times a day for 90 days. Each fish oil capsules contained approximately 210.99 mg EPA and 129.84 mg of DHA. The outcome was evaluated by means of psychometric and biological measures as well as self-reports of tobacco use. The evaluations were carried out at the beginning of treatment and once a month thereafter (total of 4 times). Outcomes: The omega-3 fatty acid lipid profile showed that smokers present lower concentrations of DHA. After treatment, the omega-3 group showed a significant reduction in their levels of dependence. Interpretation: Smokers showed lower peripheral levels of omega-3, and treatment with the most important omega-3 fatty acids brought about a reduction in nicotine dependence.

scholarly journals The effect of dietary omega-3 fatty acids (fish oil) on azoxymethanol-induced focal areas of dysplasia and colon tumor incidence

Cancer ◽  
1990 ◽  
Vol 66 (11) ◽  
pp. 2350-2356 ◽  
Author(s):  
Eleanor E. Deschner ◽  
Julia S. Lytle ◽  
George Wong ◽  
Jeanne F. Ruperto ◽  
Harold L. Newmark
Keyword(s):  
Fatty Acids ◽  
Fish Oil ◽  
Tumor Incidence ◽  
Colon Tumor ◽  
Omega 3 Fatty Acids ◽  
Omega 3

scholarly journals Effect of fish oil omega-3 fatty acids on reduction of depressive symptoms among HIV-seropositive pregnant women: a randomized, double-blind controlled trial

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Rose Okoyo Opiyo ◽  
Peter Suwirakwenda Nyasulu ◽  
Reuben Kamau Koigi ◽  
Anne Obondo ◽  
Dorington Ogoyi ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Depressive Symptoms ◽  
Fish Oil ◽  
Pregnant Women ◽  
Controlled Trial ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Double Blind ◽  
Hiv Seropositive

Delivery of Omega-3 Fatty Acids into Cake Through Emulsification of Fish Oil-in-Milk and Encapsulation by Spray Drying with Added Polymers

2014 ◽  
Vol 33 (1) ◽  
pp. 83-91 ◽  
Author(s):  
Agni Kumar Santhanam ◽  
Manjusha Lekshmi ◽  
Mithlesh Kumar Chouksey ◽  
Gayatri Tripathi ◽  
Venkateshwarlu Gudipati
Keyword(s):  
Fatty Acids ◽  
Fish Oil ◽  
Spray Drying ◽  
Omega 3 Fatty Acids ◽  
Omega 3

scholarly journals Fish Oil Derived Omega 3 Fatty Acids Suppress Adipose NLRP3 Inflammasome Signaling in Human Obesity

2018 ◽  
Vol 3 (3) ◽  
pp. 504-515 ◽  
Author(s):  
Kailey Roberts Lee ◽  
Yasmeen Midgette ◽  
Rachana Shah
Keyword(s):  
Fatty Acids ◽  
Fish Oil ◽  
Nlrp3 Inflammasome ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Human Obesity

scholarly journals USE OF FISH OIL AS SUPPLEMENT TO RICE FLOUR FOR CHILDREN

2015 ◽  
Vol 2 (1) ◽  
pp. 136
Author(s):  
Ade Nugraheni ◽  
Fifi Retiaty ◽  
K Komari
Keyword(s):  
Fatty Acids ◽  
Fish Oil ◽  
Nutrient Content ◽  
Rice Flour ◽  
Food Supplement ◽  
Soy Flour ◽  
Equal Weight ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Nutrient Contents

Fish oil is a source of omega 3 fatty acids, especially DHA and EPA having health benefits, such as prevention of heart disease and improvement of brain development including vision. However, these components are susceptible to oxidative damage and its fishy smell may affect consumer acceptance. This study aimed to immobilize this oil in rice flour usually prepared for "sumsum" porridge, a traditional meals for children or mother. Some of type of polymer are mixture with oil and was sprayed on to the rice flour to ensure the oils were coated with these polymer. Hedonic test of "sumsum" porridge was performed for acceptability for 4% fish oil and 4% equal weight of polymer malto-dextrin and soy flour. The nutrient contents were also presented. The nutrient content of the sample could be use as food supplement for under-five year children and his mother. Keywords: fish oil, applement, omega 3 fatty acids 

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