Polymeric Micelles: Polyethylene Glycol-Phosphatidylethanolamine (PEG-PE)-Based Micelles as an Example

2010 ◽  
pp. 131-149 ◽  
Author(s):  
Rupa R. Sawant ◽  
Vladimir P. Torchilin
Keyword(s):  
Polyethylene Glycol ◽  
Polymeric Micelles

Effect of the disulfide bond and polyethylene glycol on the degradation and biophysicochemical properties of polyurethane micelles

2022 ◽  
Author(s):  
Zhicheng Pan ◽  
Guangxuan Yang ◽  
Jinfeng Yuan ◽  
Mingwang Pan ◽  
Jiehua Li ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Disulfide Bond ◽  
Therapeutic Agent ◽  
Polymeric Micelles ◽  
Rapid Response

Disulfide bond has emerged as a promising redox-sensitive switch for smart polymeric micelles, due to the properties of rapid response to the reductive environment and spatiotemporally control therapeutic agent delivery....

Antibacterial activities of polymeric poly(dl-lactide-co-glycolide) nanoparticles and Soluplus® micelles against Staphylococcus epidermidis biofilm and their characterization

RSC Advances ◽  
2015 ◽  
Vol 5 (88) ◽  
pp. 71709-71717 ◽  
Author(s):  
Chisato Takahashi ◽  
Shoko Saito ◽  
Asami Suda ◽  
Noriko Ogawa ◽  
Yoshiaki Kawashima ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Drug Delivery System ◽  
Delivery System ◽  
Graft Copolymer ◽  
Staphylococcus Epidermidis ◽  
Polyvinyl Acetate ◽  
Polymeric Micelles ◽  
Antibacterial Activities

We have successfully prepared polymeric micelles based on polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol graft copolymer (Soluplus®) for a drug delivery system on a biofilm.

Near infrared light‐induced disassembly of polymeric micelles based on methylene blue conjugated polyethylene glycol

2020 ◽  
Vol 138 (2) ◽  
pp. 49665
Author(s):  
Huy Minh Dao ◽  
Amit Raviraj Pillai ◽  
Rishi Thakkar ◽  
Sanjiv Parajuli ◽  
Esteban Urena‐Benavides ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Polyethylene Glycol ◽  
Near Infrared ◽  
Polymeric Micelles ◽  
Infrared Light ◽  
Near Infrared Light

Water-soluble conjugated polymeric micelles as a carrier for studying Pt(iv) release and imaging in living cells

2020 ◽  
Vol 11 (10) ◽  
pp. 1720-1726
Author(s):  
Ting Yang ◽  
Jilin Liu ◽  
Zhiru Hu ◽  
Jie Jiang ◽  
Fei Yan ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Polymeric Micelles ◽  
Living Cells ◽  
Water Soluble ◽  
Esterification Reaction ◽  
Side Chains

Here, polyethylene glycol (PEG) was fixed on the side chains of a poly(p-phenyleneethynylene) (PPE) core via an esterification reaction, thus forming hydrophilic conjugated polymeric micelles (CPMs).

scholarly journals Solubilization of poorly soluble photosensitizer hypericin by polymeric micelles and polyethylene glycol

2013 ◽  
Vol 32 (02) ◽  
pp. 201-208 ◽  
Author(s):  
Diana Búzová ◽  
Peter Kasák ◽  
Pavol Miškovský ◽  
Daniel Jancura
Keyword(s):  
Polyethylene Glycol ◽  
Polymeric Micelles ◽  
Poorly Soluble

scholarly journals Reduction-Triggered Breakable Micelles of Amphiphilic Polyamide Amine-g-Polyethylene Glycol for Methotrexate Delivery

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Yihang Huang ◽  
Jun Liu ◽  
Yani Cui ◽  
Huanan Li ◽  
Yong Sun ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Chemical Structure ◽  
Polymeric Micelles ◽  
Drug Loading ◽  
Hydrophobic Core ◽  
The Core ◽  
Loading Efficiency ◽  
Normal Circumstance ◽  
Intracellular Compartments ◽  
Drug Loading Efficiency

Reduction-triggered breakable polymeric micelles incorporated with MTX were prepared using amphiphilic PAA-g-PEG copolymers having S–S bonds in the backbone. The micelles were spherical with diameters less than 70 nm. The micelles could encapsulate the hydrophobic MTX in the hydrophobic core. The drug loading content and drug loading efficiency of the micelles were highly dependent on the copolymer chemical structure, ranging from 2.9 to 7.5% and 31.9 to 82.5%, respectively. Both the drug loading content and drug loading efficiency increased along with more hydrophobic segments in the copolymers. In normal circumstance, these micelles were capable of keeping stable and hold most of the MTX in the core, stabilizing the incorporated MTX through theπ-πstacking with the phenyl groups in the backbone of the copolymers. In reductive environments that mimicked the intracellular compartments, the entire MTX payload could be quickly released due to the reduction-triggered breakage of the micelles. These micelles showed good antiproliferative activity against several cancer cell lines, including KB, 4T-1 and HepG2, especially within the low drug concentration scope.

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