A Novel Monomethoxy Polyethylene Glycol^|^#8211;Polylactic Acid Polymeric Micelles with Higher Loading Capacity for Docetaxel and Well-Reconstitution Characteristics and Its Anti-metastasis Study

Preparation and application of sustainable polymers derived from renewable resources are of great significance. The aim of this study is to synthesize a kind of sustainable polymeric micelles from rosin and vegetable oils via atom transfer radical polymerization (ATRP) and to investigate the doxorubicin delivery properties of these micelles. Dehydroabietic acid–based poly lauryl methacrylate (DA-PLMA) with narrow PDI of 1.13 was prepared in a well-controlled process using rosin as an ATRP initiator. Thereafter, carboxylic groups were introduced to form poly methacrylic acid (PMAA) moieties in DA-PLMA polymer via acid hydrolysis. The resulted DA-PLMA-PMAA could self-assemble in water to form pH-dependent polymeric micelles with a diameter of ∼65 nm and PDI as low as 0.105. Owing to the existence of rosin, DA-PLMA-PMAA micelles also showed self-fluorescence properties. In addition, Dox-loaded micelles were prepared in aqueous solution with the drug-loading capacity as high as 16.0% and showed sustained-release characteristics. These results demonstrate great promise for designing polymeric micellar from rosin and vegetable oils.

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Surface Modifications of Superparamagnetic Iron Oxide Nanoparticles with Polylactic Acid-Polyethylene Glycol Diblock Copolymer and Graphene Oxide for a Protein Delivery Vehicle

Engineered Science ◽

10.30919/es8d510 ◽

2019 ◽

Cited By ~ 4

Author(s):

Linh Doan ◽

◽

Yang Lu ◽

Megha Karatela ◽

Vu Phan ◽

...

Keyword(s):

Graphene Oxide ◽

Polyethylene Glycol ◽

Iron Oxide ◽

Polylactic Acid ◽

Diblock Copolymer ◽

Protein Delivery ◽

Superparamagnetic Iron Oxide ◽

Surface Modifications ◽

Oxide Nanoparticles ◽

Delivery Vehicle

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Materials design with polylactic acid-polyethylene glycol blends using 3D printing and for medical applications.

10.18297/etd/2886 ◽

2018 ◽

Author(s):

Jeremiah Bauer

Keyword(s):

Polyethylene Glycol ◽

3D Printing ◽

Polylactic Acid ◽

Materials Design ◽

Medical Applications

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A single dose of dexamethasone encapsulated in polyethylene glycol-coated polylactic acid nanoparticles attenuates cisplatin-induced hearing loss following round window membrane administration

International Journal of Nanomedicine ◽

10.2147/ijn.s77912 ◽

2015 ◽

pp. 3567 ◽

Cited By ~ 2

Author(s):

Dehong Yu ◽

Hao Wu ◽

Changling Sun ◽

Fuxin Shi ◽

Xiaoqi Wang ◽

...

Keyword(s):

Hearing Loss ◽

Single Dose ◽

Polyethylene Glycol ◽

Polylactic Acid ◽

Round Window ◽

Round Window Membrane

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Effect of the disulfide bond and polyethylene glycol on the degradation and biophysicochemical properties of polyurethane micelles

Biomaterials Science ◽

10.1039/d1bm01422f ◽

2022 ◽

Author(s):

Zhicheng Pan ◽

Guangxuan Yang ◽

Jinfeng Yuan ◽

Mingwang Pan ◽

Jiehua Li ◽

...

Keyword(s):

Polyethylene Glycol ◽

Disulfide Bond ◽

Therapeutic Agent ◽

Polymeric Micelles ◽

Rapid Response

Disulfide bond has emerged as a promising redox-sensitive switch for smart polymeric micelles, due to the properties of rapid response to the reductive environment and spatiotemporally control therapeutic agent delivery....

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The Development of Thermostatically Biodegradable Composite

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.889.44 ◽

2021 ◽

Vol 889 ◽

pp. 44-49

Author(s):

Yeng Fong Shih ◽

Zheng Ting Chen ◽

Wei Lun Lin ◽

Po Chun Chiu ◽

Chin Hsien Chiang ◽

...

Keyword(s):

Tensile Strength ◽

Polyethylene Glycol ◽

Maleic Anhydride ◽

Impact Strength ◽

Polylactic Acid ◽

Deformation Temperature ◽

Thermal Deformation ◽

Biodegradable Composite ◽

New Type ◽

Polybutylene Succinate

The purpose of this research is to develop a new type of environmentally friendly container which has thermostatic effect and is biodegradable. This study is based on polylactic acid (PLA) and maleic anhydride grafted polybutylene succinate (MAPBS). Subsequently, the diatomite which adsorbed polyethylene glycol (PEG) was added to prepare a thermostatic biodegradable composite. The addition of MAPBS is to improve the compatibility between PLA and diatomite. In addition, the thermostatic effect, tensile strength, thermal deformation temperature and impact strength of the composite were investigated.

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