Antibacterial activities of polymeric poly(dl-lactide-co-glycolide) nanoparticles and Soluplus® micelles against Staphylococcus epidermidis biofilm and their characterization

RSC Advances ◽  
2015 ◽  
Vol 5 (88) ◽  
pp. 71709-71717 ◽  
Author(s):  
Chisato Takahashi ◽  
Shoko Saito ◽  
Asami Suda ◽  
Noriko Ogawa ◽  
Yoshiaki Kawashima ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Drug Delivery System ◽  
Delivery System ◽  
Graft Copolymer ◽  
Staphylococcus Epidermidis ◽  
Polyvinyl Acetate ◽  
Polymeric Micelles ◽  
Antibacterial Activities

We have successfully prepared polymeric micelles based on polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol graft copolymer (Soluplus®) for a drug delivery system on a biofilm.

scholarly journals Polyethylene Glycol Functionalized Graphene Oxide Nanoparticles Loaded with Nigella sativa Extract: A Smart Antibacterial Therapeutic Drug Delivery System

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3067
Author(s):  
Mustafa A. Jihad ◽  
Farah T. M. Noori ◽  
Majid S. Jabir ◽  
Salim Albukhaty ◽  
Faizah A. AlMalki ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Grain Size ◽  
Cell Wall ◽  
Graphene Oxide ◽  
Polyethylene Glycol ◽  
Nucleic Acid ◽  
Drug Delivery System ◽  
Delivery System ◽  
Nigella Sativa ◽  
Seed Extract

Flaky graphene oxide (GO) nanoparticles (NPs) were synthesized using Hummer’s method and then capped with polyethylene glycol (PEG) by an esterification reaction, then loaded with Nigella sativa (N. sativa) seed extract. Aiming to investigate their potential use as a smart drug delivery system against Staphylococcus aureus and Escherichia coli, the spectral and structural characteristics of GO-PEG NPs were comprehensively analyzed by XRD, AFM, TEM, FTIR, and UV- Vis. XRD patterns revealed that GO-PEG had different crystalline structures and defects, as well as a higher interlayer spacing. AFM results showed GONPs with the main grain size of 24.41 nm, while GONPs–PEG revealed graphene oxide aggregation with the main grain size of 287.04 nm after loading N. sativa seed extract, which was verified by TEM examination. A strong OH bond appeared in FTIR spectra. Furthermore, UV- Vis absorbance peaks at (275, 284, 324, and 327) nm seemed to be correlated with GONPs, GO–PEG, N. sativa seed extract, and GO –PEG- N. sativa extract. The drug delivery system was observed to destroy the bacteria by permeating the bacterial nucleic acid and cytoplasmic membrane, resulting in the loss of cell wall integrity, nucleic acid damage, and increased cell-wall permeability.

scholarly journals Synthesis and Characterization of Methotrexate Polyethylene Glycol Esters as a Drug Delivery System

2010 ◽  
Vol 58 (2) ◽  
pp. 147-153 ◽  
Author(s):  
Gholamhossein Yousefi ◽  
Seyed Mohsen Foroutan ◽  
Afshin Zarghi ◽  
Alireza Shafaati
Keyword(s):  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Drug Delivery System ◽  
Delivery System ◽  
Synthesis And Characterization

Polymeric micelles as a drug delivery system enhance cytotoxicity of vinorelbine through more intercellular accumulation

Drug Delivery ◽  
2010 ◽  
Vol 17 (4) ◽  
pp. 255-262 ◽  
Author(s):  
Xiaoyan Lu ◽  
Fayun Zhang ◽  
Lei Qin ◽  
Fengying Xiao ◽  
Wei Liang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polymeric Micelles

Polymeric micelles drug delivery system in oncology

2012 ◽  
Vol 159 (3) ◽  
pp. 312-323 ◽  
Author(s):  
Jian Gong ◽  
Meiwan Chen ◽  
Ying Zheng ◽  
Shengpeng Wang ◽  
Yitao Wang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polymeric Micelles
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