Tissue Engineering Strategies for Cardiac Regeneration

2011 ◽  
pp. 443-475 ◽  
Author(s):  
Amandine F. G. Godier-Furnémont ◽  
Yi Duan ◽  
Robert Maidhof ◽  
Gordana Vunjak-Novakovic
Keyword(s):  
Tissue Engineering ◽  
Cardiac Regeneration

scholarly journals Polymeric Biomaterials for the Treatment of Cardiac Post-Infarction Injuries

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1038
Author(s):  
Sonia Trombino ◽  
Federica Curcio ◽  
Roberta Cassano ◽  
Manuela Curcio ◽  
Giuseppe Cirillo ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cardiac Tissue ◽  
Polymeric Nanoparticles ◽  
Three Dimensional ◽  
Cardiac Regeneration ◽  
Biological Properties ◽  
Positive Influence ◽  
Regenerative Process ◽  
Current Status ◽  
Polymeric Biomaterials

Cardiac regeneration aims to reconstruct the heart contractile mass, preventing the organ from a progressive functional deterioration, by delivering pro-regenerative cells, drugs, or growth factors to the site of injury. In recent years, scientific research focused the attention on tissue engineering for the regeneration of cardiac infarct tissue, and biomaterials able to anatomically and physiologically adapt to the heart muscle have been proposed as valuable tools for this purpose, providing the cells with the stimuli necessary to initiate a complete regenerative process. An ideal biomaterial for cardiac tissue regeneration should have a positive influence on the biomechanical, biochemical, and biological properties of tissues and cells; perfectly reflect the morphology and functionality of the native myocardium; and be mechanically stable, with a suitable thickness. Among others, engineered hydrogels, three-dimensional polymeric systems made from synthetic and natural biomaterials, have attracted much interest for cardiac post-infarction therapy. In addition, biocompatible nanosystems, and polymeric nanoparticles in particular, have been explored in preclinical studies as drug delivery and tissue engineering platforms for the treatment of cardiovascular diseases. This review focused on the most employed natural and synthetic biomaterials in cardiac regeneration, paying particular attention to the contribution of Italian research groups in this field, the fabrication techniques, and the current status of the clinical trials.

scholarly journals Myocardial Restoration: Is It the Cell or the Architecture or Both?

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Duc Thang Vu ◽  
Theo Kofidis
Keyword(s):  
Myocardial Infarction ◽  
Tissue Engineering ◽  
Clinical Trials ◽  
Cell Therapy ◽  
Cardiac Regeneration ◽  
Developed Countries ◽  
Cardiac Cell ◽  
Cardiac Cell Therapy ◽  
Promising Solution ◽  
Structural Aspects

Myocardial infarction is the leading cause of death in developed countries. Cardiac cell therapy has been introduced to clinical trials for more than ten years but its results are still controversial. Tissue engineering has addressed some limitations of cell therapy and appears to be a promising solution for cardiac regeneration. In this review, we would like to summarize the current understanding about the therapeutic effect of cell therapy and tissue engineering under purview of functional and structural aspects, highlighting actual roles of each therapy towards clinical application.

Tissue Engineering for Cardiac Regeneration

2011 ◽  
pp. 1-27 ◽  
Author(s):  
Roberto Gaetani ◽  
Pieter A. F. Doevendans ◽  
Elisa Messina ◽  
Joost P. G. Sluijter
Keyword(s):  
Tissue Engineering ◽  
Cardiac Regeneration

scholarly journals Nanoengineering in Cardiac Regeneration: Looking Back and Going Forward

Nanomaterials ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1587
Author(s):  
Caterina Cristallini ◽  
Emanuela Vitale ◽  
Claudia Giachino ◽  
Raffaella Rastaldo
Keyword(s):  
Tissue Engineering ◽  
Experimental Study ◽  
Extracellular Matrix ◽  
Regenerative Medicine ◽  
Cardiac Tissue ◽  
Cardiac Regeneration ◽  
Cardiac Cells ◽  
Integration Process ◽  
Specific Interest ◽  
Looking Back

To deliver on the promise of cardiac regeneration, an integration process between an emerging field, nanomedicine, and a more consolidated one, tissue engineering, has begun. Our work aims at summarizing some of the most relevant prevailing cases of nanotechnological approaches applied to tissue engineering with a specific interest in cardiac regenerative medicine, as well as delineating some of the most compelling forthcoming orientations. Specifically, this review starts with a brief statement on the relevant clinical need, and then debates how nanotechnology can be combined with tissue engineering in the scope of mimicking a complex tissue like the myocardium and its natural extracellular matrix (ECM). The interaction of relevant stem, precursor, and differentiated cardiac cells with nanoengineered scaffolds is thoroughly presented. Another correspondingly relevant area of experimental study enclosing both nanotechnology and cardiac regeneration, e.g., nanoparticle applications in cardiac tissue engineering, is also discussed.

Cell therapy, 3D culture systems and tissue engineering for cardiac regeneration

2014 ◽  
Vol 69-70 ◽  
pp. 254-269 ◽  
Author(s):  
Maximilian Y. Emmert ◽  
Robert W. Hitchcock ◽  
Simon P. Hoerstrup
Keyword(s):  
Tissue Engineering ◽  
Cell Therapy ◽  
3D Culture ◽  
Cardiac Regeneration ◽  
Culture Systems

A bird's-eye view of cell therapy and tissue engineering for cardiac regeneration

2012 ◽  
Vol 1254 (1) ◽  
pp. 57-65 ◽  
Author(s):  
Carolina Soler-Botija ◽  
Juli R. Bagó ◽  
Antoni Bayes-Genis
Keyword(s):  
Tissue Engineering ◽  
Cell Therapy ◽  
Cardiac Regeneration

scholarly journals Current challenges in three-dimensional bioprinting heart tissues for cardiac surgery

2020 ◽  
Vol 58 (3) ◽  
pp. 500-510 ◽  
Author(s):  
Christopher D Roche ◽  
Russell J L Brereton ◽  
Anthony W Ashton ◽  
Christopher Jackson ◽  
Carmine Gentile
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Cardiac Surgery ◽  
Contractile Function ◽  
Three Dimensional ◽  
Cardiac Regeneration ◽  
Heart Tissue ◽  
Myocardial Tissue ◽  
3 Dimensional ◽  
Myocardial Tissue Engineering

Abstract Summary Previous attempts in cardiac bioengineering have failed to provide tissues for cardiac regeneration. Recent advances in 3-dimensional bioprinting technology using prevascularized myocardial microtissues as ‘bioink’ have provided a promising way forward. This review guides the reader to understand why myocardial tissue engineering is difficult to achieve and how revascularization and contractile function could be restored in 3-dimensional bioprinted heart tissue using patient-derived stem cells.

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