Smart Materials for Tissue Engineering

Author(s):  
Timothy M. O’Shea ◽  
Alexander L. Wollenberg ◽  
Alexander M. Bernstein ◽  
Darren B. Sarte ◽  
Timothy J. Deming ◽  
...  

2020 ◽  
Vol 4 (4) ◽  
pp. 1089-1104 ◽  
Author(s):  
Fang Fang ◽  
Fanling Meng ◽  
Liang Luo

This review summarized most recent advances of designing strategies of polydiacetylene-based smart biomaterials with unique colorimetric and mechanical properties, as well as their applications in biosensing, drug delivery, and tissue engineering.


MRS Bulletin ◽  
2005 ◽  
Vol 30 (3) ◽  
pp. 185-188 ◽  
Author(s):  
Joerg Lahann ◽  
Robert Langer

AbstractRecent progress in various biotechnology fields, such as microfluidics, tissue engineering, and cellular biology, has created a great demand for substrates that can undergo defined remodeling with time. As a result, the latest research on materials with dynamically controllable surface properties has led to a variety of novel smart surface designs.


2020 ◽  
Vol 21 (13) ◽  
pp. 4724 ◽  
Author(s):  
Sofia Municoy ◽  
María I. Álvarez Echazú ◽  
Pablo E. Antezana ◽  
Juan M. Galdopórpora ◽  
Christian Olivetti ◽  
...  

Smart or stimuli-responsive materials are an emerging class of materials used for tissue engineering and drug delivery. A variety of stimuli (including temperature, pH, redox-state, light, and magnet fields) are being investigated for their potential to change a material’s properties, interactions, structure, and/or dimensions. The specificity of stimuli response, and ability to respond to endogenous cues inherently present in living systems provide possibilities to develop novel tissue engineering and drug delivery strategies (for example materials composed of stimuli responsive polymers that self-assemble or undergo phase transitions or morphology transformations). Herein, smart materials as controlled drug release vehicles for tissue engineering are described, highlighting their potential for the delivery of precise quantities of drugs at specific locations and times promoting the controlled repair or remodeling of tissues.


2020 ◽  
Vol 12 (24) ◽  
pp. 10628
Author(s):  
Ankur Bajpai ◽  
Anna Baigent ◽  
Sakshika Raghav ◽  
Conchúr Ó. Brádaigh ◽  
Vasileios Koutsos ◽  
...  

4D printing can be defined as the fabrication of structures using smart materials that allow the final object to change its shape, properties, or function in response to an external stimulus such as light, heat, or moisture. The available technologies, materials, and applications have evolved significantly since their first development in 2013, with prospective applications within the aerospace, manufacturing, and soft robotic industries. This review focuses on the printing technologies and smart materials currently available for fabricating these structures. The applications of 4D printing within biomedicine are explored with a focus on tissue engineering, drug delivery, and artificial organs. Finally, some ideas for potential uses are proposed. 4D printing is making its mark with seemingly unlimited potential applications, however, its use in mainstream medical treatments relies on further developments and extensive research investments.


2021 ◽  
Vol 22 (23) ◽  
pp. 13047
Author(s):  
Maria Grazia Tupone ◽  
Gloria Panella ◽  
Michele d’Angelo ◽  
Vanessa Castelli ◽  
Giulia Caioni ◽  
...  

Thanks to their reduced size, great surface area, and capacity to interact with cells and tissues, nanomaterials present some attractive biological and chemical characteristics with potential uses in the field of biomedical applications. In this context, graphene and its chemical derivatives have been extensively used in many biomedical research areas from drug delivery to bioelectronics and tissue engineering. Graphene-based nanomaterials show excellent optical, mechanical, and biological properties. They can be used as a substrate in the field of tissue engineering due to their conductivity, allowing to study, and educate neural connections, and guide neural growth and differentiation; thus, graphene-based nanomaterials represent an emerging aspect in regenerative medicine. Moreover, there is now an urgent need to develop multifunctional and functionalized nanomaterials able to arrive at neuronal cells through the blood-brain barrier, to manage a specific drug delivery system. In this review, we will focus on the recent applications of graphene-based nanomaterials in vitro and in vivo, also combining graphene with other smart materials to achieve the best benefits in the fields of nervous tissue engineering and neural regenerative medicine. We will then highlight the potential use of these graphene-based materials to construct graphene 3D scaffolds able to stimulate neural growth and regeneration in vivo for clinical applications.


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