Female Sexual Dysfuntion: Effective Treatment Strategies for All Ages

2007 ◽  
pp. 106-123
Author(s):  
Laura A.C. Berman ◽  
Kerrie A. Grow McLean
Keyword(s):  
Effective Treatment ◽  
Treatment Strategies

scholarly journals Targeting Inflammasome Activation in COVID-19: Delivery of RNA Interference-Based Therapeutic Molecules

Biomedicines ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1823
Author(s):  
Lealem Gedefaw ◽  
Sami Ullah ◽  
Thomas M. H. Lee ◽  
Shea Ping Yip ◽  
Chien-Ling Huang
Keyword(s):  
Rna Interference ◽  
Effective Treatment ◽  
Critical Role ◽  
Treatment Strategies ◽  
Drug Efficacy ◽  
Immune Dysregulation ◽  
Inflammasome Activation ◽  
Mortality And Morbidity ◽  
Therapeutic Molecules ◽  
Non Coding Rnas

Mortality and morbidity associated with COVID-19 continue to be significantly high worldwide, owing to the absence of effective treatment strategies. The emergence of different variants of SARS-CoV-2 is also a considerable source of concern and has led to challenges in the development of better prevention and treatment strategies, including vaccines. Immune dysregulation due to pro-inflammatory mediators has worsened the situation in COVID-19 patients. Inflammasomes play a critical role in modulating pro-inflammatory cytokines in the pathogenesis of COVID-19 and their activation is associated with poor clinical outcomes. Numerous preclinical and clinical trials for COVID-19 treatment using different approaches are currently underway. Targeting different inflammasomes to reduce the cytokine storm, and its associated complications, in COVID-19 patients is a new area of research. Non-coding RNAs, targeting inflammasome activation, may serve as an effective treatment strategy. However, the efficacy of these therapeutic agents is highly dependent on the delivery system. MicroRNAs and long non-coding RNAs, in conjunction with an efficient delivery vehicle, present a potential strategy for regulating NLRP3 activity through various RNA interference (RNAi) mechanisms. In this regard, the use of nanomaterials and other vehicle types for the delivery of RNAi-based therapeutic molecules for COVID-19 may serve as a novel approach for enhancing drug efficacy. The present review briefly summarizes immune dysregulation and its consequences, the roles of different non-coding RNAs in regulating the NLRP3 inflammasome, distinct types of vectors for their delivery, and potential therapeutic targets of microRNA for treatment of COVID-19.

scholarly journals Therapeutically targeting cyclin D1 in primary tumors arising from loss of Ini1

2010 ◽  
Vol 108 (1) ◽  
pp. 319-324 ◽  
Author(s):  
Melissa E. Smith ◽  
Velasco Cimica ◽  
Srinivasa Chinni ◽  
Suman Jana ◽  
Wade Koba ◽  
...  
Keyword(s):  
Cyclin D1 ◽  
Effective Treatment ◽  
Treatment Strategies ◽  
Suppressor Gene ◽  
Therapeutic Strategies ◽  
Genetically Engineered ◽  
Primary Tumors ◽  
Rhabdoid Tumors ◽  
High Level ◽  
Resistant Cells

Rhabdoid tumors (RTs) are rare, highly aggressive pediatric malignancies with poor prognosis and with no standard or effective treatment strategies. RTs are characterized by biallelic inactivation of the INI1 tumor suppressor gene. INI1 directly represses CCND1 and activates cyclin-dependent kinase (cdk) inhibitors p16Ink4a and p21CIP. RTs are exquisitely dependent on cyclin D1 for genesis and survival. To facilitate translation of unique therapeutic strategies, we have used genetically engineered, Ini1+/− mice for therapeutic testing. We found that PET can be used to noninvasively and accurately detect primary tumors in Ini1+/− mice. In a PET-guided longitudinal study, we found that treating Ini1+/− mice bearing primary tumors with the pan-cdk inhibitor flavopiridol resulted in complete and stable regression of some tumors. Other tumors showed resistance to flavopiridol, and one of the resistant tumors overexpressed cyclin D1, more than flavopiridol-sensitive cells. The concentration of flavopiridol used was not sufficient to down-modulate the high level of cyclin D1 and failed to induce cell death in the resistant cells. Furthermore, FISH and PCR analyses indicated that there is aneuploidy and increased CCND1 copy number in resistant cells. These studies indicate that resistance to flavopiridol may be correlated to elevated cyclin D1 levels. Our studies also indicate that Ini1+/− mice are valuable tools for testing unique therapeutic strategies and for understanding mechanisms of drug resistance in tumors that arise owing to loss of Ini1, which is essential for developing effective treatment strategies against these aggressive tumors.

scholarly journals Effective treatment strategies for paediatric community-acquired pneumonia

2007 ◽  
Vol 8 (8) ◽  
pp. 1091-1101 ◽  
Author(s):  
Maria Atkinson ◽  
Michael Yanney ◽  
Terence Stephenson ◽  
Alan Smyth
Keyword(s):  
Effective Treatment ◽  
Treatment Strategies ◽  
Community Acquired Pneumonia

scholarly journals The Communication Between Intestinal Microbiota and Ulcerative Colitis: An Exploration of Pathogenesis, Animal Models, and Potential Therapeutic Strategies

2021 ◽  
Vol 8 ◽  
Author(s):  
Yu Hu ◽  
Zhen Ye ◽  
Mingquan Wu ◽  
Yingqi She ◽  
Linzhen Li ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Animal Models ◽  
Effective Treatment ◽  
Intestinal Microbiota ◽  
Therapeutic Potential ◽  
Treatment Strategies ◽  
Therapeutic Strategies ◽  
Sufficient Evidence ◽  
Chronic Inflammatory Bowel Disease ◽  
Preclinical Research

Ulcerative Colitis (UC) is a chronic inflammatory bowel disease. The prolonged course of UC and the lack of effective treatment management make it difficult to cure, affecting the health and life safety of patients. Although UC has received more attention, the etiology and pathogenesis of UC are still unclear. Therefore, it is urgent to establish an updated and comprehensive understanding of UC and explore effective treatment strategies. Notably, sufficient evidence shows that the intestinal microbiota plays an important role in the pathogenesis of UC, and the treating method aimed at improving the balance of the intestinal microbiota exhibits a therapeutic potential for UC. This article reviews the relationship between the genetic, immunological and microbial risk factors with UC. At the same time, the UC animal models related to intestinal microbiota dysbiosis induced by chemical drugs were evaluated. Finally, the potential value of the therapeutic strategies for restoring intestinal microbial homeostasis and treating UC were also investigated. Comprehensively, this study may help to carry out preclinical research, treatment theory and methods, and health management strategy of UC, and provide some theoretical basis for TCM in the treatment of UC.

scholarly journals Current Clinical Concepts: Clinical Management of Patellar Tendinopathy

2021 ◽  
Author(s):  
Adam B. Rosen ◽  
Elizabeth Wellsandt ◽  
Mike Nicola ◽  
Matthew A. Tao
Keyword(s):  
Effective Treatment ◽  
Clinical Management ◽  
Management Strategies ◽  
Treatment Strategies ◽  
Patellar Tendinopathy ◽  
Load Management ◽  
Evidence Based ◽  
Effective Treatment Option ◽  
Treatment Interventions

ABSTRACT Patellar tendinopathy is a common, yet misunderstood pathoetiology afflicting a variety of patient populations. This lack of unified understanding affects the capability of clinicians to provide effective treatment interventions. Patients with tendinopathy often report long-term and low to moderate levels of pain, diminished flexibility, and strength, as well as decreased physical function. Load-management strategies combined with exercise regimens focused on progressive tendon loading are the most effective treatment option for patients with patellar tendinopathy. This review will provide an evidence-based approach to patellar tendinopathy, including its pathoetiology, evaluation, and treatment strategies.

scholarly journals Targeting Endoplasmic Reticulum Stress as an Effective Treatment for Alcoholic Pancreatitis

Biomedicines ◽  
2022 ◽  
Vol 10 (1) ◽  
pp. 108
Author(s):  
Hui Li ◽  
Wen Wen ◽  
Jia Luo
Keyword(s):  
Endoplasmic Reticulum ◽  
Er Stress ◽  
Effective Treatment ◽  
Stress Responses ◽  
Treatment Strategies ◽  
Alcoholic Pancreatitis ◽  
Excessive Alcohol Consumption ◽  
Unfolded Protein ◽  
Novel Therapeutic Strategies ◽  
Protein Response

Pancreatitis and alcoholic pancreatitis are serious health concerns with an urgent need for effective treatment strategies. Alcohol is a known etiological factor for pancreatitis, including acute pancreatitis (AP) and chronic pancreatitis (CP). Excessive alcohol consumption induces many pathological stress responses; of particular note is endoplasmic reticulum (ER) stress and adaptive unfolded protein response (UPR). ER stress results from the accumulation of unfolded/misfolded protein in the ER and is implicated in the pathogenesis of alcoholic pancreatitis. Here, we summarize the possible mechanisms by which ER stress contributes to alcoholic pancreatitis. We also discuss potential approaches targeting ER stress and UPR in developing novel therapeutic strategies for the disease.

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