Developing a Surgical Clinical Research Question: To Find the Answer in Literature Search or in Pursuing Clinical Research

2019 ◽  
pp. 17-22
Author(s):  
Achilles Thoma ◽  
Sheila Sprague ◽  
Sophocles H. Voineskos ◽  
Jessica Murphy
BMJ Open ◽  
2022 ◽  
Vol 12 (1) ◽  
pp. e052953
Author(s):  
Timothy Peter Clark ◽  
Brennan C Kahan ◽  
Alan Phillips ◽  
Ian White ◽  
James R Carpenter

Precise specification of the research question and associated treatment effect of interest is essential in clinical research, yet recent work shows that they are often incompletely specified. The ICH E9 (R1) Addendum on Estimands and Sensitivity Analysis in Clinical Trials introduces a framework that supports researchers in precisely and transparently specifying the treatment effect they aim to estimate in their clinical trial. In this paper, we present practical examples to demonstrate to all researchers involved in clinical trials how estimands can help them to specify the research question, lead to a better understanding of the treatment effect to be estimated and hence increase the probability of success of the trial.


Author(s):  
João Rafael Almeida ◽  
João Figueira Silva ◽  
Sérgio Matos ◽  
Alejandro Pazos ◽  
José Luís Oliveira

The process of refining the research question in a medical study depends greatly on the current background of the investigated subject. The information found in prior works can directly impact several stages of the study, namely the cohort definition stage. Besides previous published methods, researchers could also leverage on other materials, such as the output of cohort selection tools, to enrich and to accelerate their own work. However, this kind of information is not always captured by search engines. In this paper, we present a methodology, based on a combination of content-based retrieval and text annotation techniques, to identify relevant scientific publications related to a research question and to the selected data sources.


2020 ◽  
pp. 1-6
Author(s):  
João Lopes ◽  
◽  
Gisele Lopes ◽  

The voice is a manifestation of the muscular process, but with psychological basis, thus being an important aspect in performance and gender recognition. The transgender person finds him/herself in biological bodies not recognized by him/her. Many of them undergo hormone treatments and surgeries to suit their gender identity and value interventions in their body and voice. Objective: To explain the importance of the relationship between orofacial motricity and voice in the phonotherapeutic work to confirm the transgender voice. Methods: A literature search was conducted covering the period from 2010 to 2020, including articles with experimental validation, which discussed therapy techniques or evaluation instruments. Results: The search resulted in 1512 publications. After applying the inclusion and exclusion criteria, 31 articles were selected. After detailed analysis of the selected abstracts and prioritization of the discussion of orofacial motricity elements, nine articles were chosen for critical analysis. All selected articles contributed to clarify the research question. Conclusion: Orofacial motricity plays a fundamental role in the confirmation of the transgender voice.


Author(s):  
Muhammad Nuruddeen

This paper explains the legal critical literature review in the critical context of the logic of scholarship. The paper asks what makes a critical literature review effective in research. It suggests that critical literature reviews are effective in research when they more easily allow the identification of research gaps, in the specified context. The methodology employs cumulative synthesis from the relevant materials, following Bentham’s ideas on synthesis, that analysis opposes both generalization and synthesis. The paper begins its argument by outlining the nature of a critical literature review. Then, it proceeds with a review of key terms required by the writer. Following this essential background, the paper discusses literature gaps and literature search methodologies. Then it moves on to the ideal format of a critical literature review. Finally, argument deals with the purpose of a critical literature review and techniques for writing the critical literature review. A legal critical literature review will be maximally effective when it sets a correct context for research, identifies fallacies in the scholarship in order to discover research gaps, and then forms this outcome into a central research question. Keywords: legal critical literature review, research gaps, fallacies, research question.


2018 ◽  
Vol 4 (2) ◽  
pp. 242
Author(s):  
Maria José Sousa ◽  
Jorge Miguel Martins ◽  
Miguel Sousa ◽  
◽  
◽  
...  

Since the last decade, the concepts of green innovation and green economy have become more and more attractive to researchers and policymakers. This research brings some light to the association of those themes with the concept of green energy. Therefore, this paper is a critical review of the green innovations directed explicitly to the green energy challenges faced by organizations and the world economies. The research question is as follows: What are the main dimensions of a model to implement a green innovation process focused on green energy in organizations? The methodology used to answer the research question was qualitative, and the main techniques included a systematic literature search and survey. The main findings of the study were the identification of the most relevant dimensions of a green innovation model to be implemented in organizations. The article structure is based on the different concepts about innovation and green innovation, related to the green economy, and the analysis of two situational cases on green energy. Finally, we present the analysis made on the articles identified by the literature survey and the green innovation model. By making this research on green economy and related concepts of green innovation and green energy, this paper seeks to make a valid contribution to their definitions and for operationalizing the green innovation model in organizations.


2019 ◽  
Vol 82 (2) ◽  
Author(s):  
Rodrigo Pessoa Cavalcanti Lira ◽  
Eduardo Melani Rocha

Epigenomics ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 543-558 ◽  
Author(s):  
Irena Abramovic ◽  
Monika Ulamec ◽  
Bojanac Katusic A ◽  
Floriana Bulic-Jakus ◽  
Davor Jezek ◽  
...  

Prostate cancer (PCa) represents the most commonly diagnosed neoplasm among men. miRNAs, as biomarkers, could further improve reliability in distinguishing malignant versus nonmalignant, and aggressive versus nonaggressive PCa. However, conflicting data was reported for certain miRNAs, and there was a lack of consistency and reproducibility, which has been attributed to diverse (pre)analytical factors. In order to address current challenges in miRNA clinical research on PCa, a PubMed-based literature search was conducted with the last update in May 2019. After identifying critical variations in designs and protocols that undermined clear-cut evidence acquisition, and reliable translation into clinical practice, we propose guidelines for most critical steps that should be considered in future research of miRNA as biomarkers, especially in PCa.


2005 ◽  
Vol 19 (4) ◽  
pp. 1-21 ◽  
Author(s):  
Fred G. Barker ◽  
Bob S. Carter

Systematic reviews and metaanalyses have become increasingly popular ways of summarizing, and sometimes extending, existing medical knowledge. In this review the authors summarize current methods of performing meta-analyses, including the following: formulating a research question; performing a structured literature search and a search for trials not published in the formal medical literature; summarizing and, where appropriate, combining results from several trials; and reporting and presenting results. Topics such as cumulative and Bayesian metaanalysis and metaregression are also addressed. References to textbooks, articles, and Internet resources are also provided. The goal is to assist readers who wish to perform their own metaanalysis or to interpret critically a published example.


2021 ◽  
Vol 18 (4) ◽  
pp. 877-888
Author(s):  
Sunil Kumar Vaddamanu ◽  
Saad M. Al Qahtani ◽  
Ravi Kadur Sundarraj ◽  
Raghavendra Reddy Nagate ◽  
Vijay Apparaju

Purpose: To assess the effectiveness of calcium sodium phosphosilicate in reducing dentin hypersensitivity compared to other dentin tubule occluding molecules. Methods: A structured research question was formulated, and an electronic search of available literature was carried out via PubMed, Google Scholar, and Scopus. A hand search as well as a gray literature search were also carried out. The search produced a total of 67 articles. Of these, only eight articles were eligible to be included in our review. Risk of bias and study quality were checked using Cochrane tool. The review was registered in The International Prospective Register of Systematic Reviews (PROSPERO) under registration number CRD42018096200. Results: The results show a reduction in dentin hypersensitivity with calcium sodium phosphosilicate compared to many other molecules. However, nanohydroxyapatite showed a better desensitizing effect compared to Novamin. Conclusion: According to the available evidence, 5 % calcium sodium phosphosilicate containing toothpaste is more effective reducing dentin hypersensitivity compared to many other dentinal tubule occluding molecules.


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