scholarly journals EXOtrainer Project Clinical Evaluation of Gait Training with Exoskeleton in Children with Spinal Muscular Atrophy

2019 ◽  
pp. 211-227 ◽  
Author(s):  
Daniel Sanz-Merodio ◽  
Gonzalo Puyuelo ◽  
Amartya Ganguly ◽  
Elena Garces ◽  
Ane Goñi ◽  
...  
Keyword(s):  
Spinal Muscular Atrophy ◽  
Clinical Evaluation ◽  
Muscular Atrophy ◽  
Gait Training

scholarly journals Influence of hybrid assistive limb gait training on spatial muscle activation patterns in spinal muscular atrophy type III

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 214
Author(s):  
Yuichi Nishikawa ◽  
Kohei Watanabe ◽  
Naoya Orita ◽  
Noriaki Maeda ◽  
Hiroaki Kimura ◽  
...  
Keyword(s):  
Spinal Muscular Atrophy ◽  
Muscle Activation ◽  
Muscular Atrophy ◽  
Training Session ◽  
Gait Training ◽  
Post Intervention ◽  
Spinal Muscular Atrophy Type ◽  
Type Iii ◽  
Hybrid Assistive Limb ◽  
Modified Entropy

Background: Despite the potential benefits, the effects of Hybrid Assistive Limb (HAL) gait training on changes in neuromuscular activation that accompany functional gains in individuals with spinal muscular atrophy (SMA) type III is not well known. In this article, we quantify the effects of HAL gait training on spatial muscle activity patterns in a patient with SMA type III using multi-channel surface electromyography (SEMG). Methods: A 21-years old male (168 cm, 47.8 kg) with spinal muscular atrophy type III, when diagnosed at 18-years old by genetic screening, participated in this case study. Although he presented with forearm distal muscle weakness, atrophy of the intrinsic muscles of the hand, and neuromuscular fatigue, his activities of daily living is independent. The patient underwent a separate, single 33-minute session of both HAL and treadmill gait training. To evaluate the coefficient of variation (CoV) of force and alterations in the SEMG spatial distribution patterns, modified entropy and CoV of root mean square (RMS) were calculated from the vastus lateralis (VL) muscle before and after the intervention of HAL and treadmill gait training. Each training session was separated by a period of one month to avoid cross-over effects. Results: There was a greater decrease in the ΔCoV of force and an increase in the magnitude of whole VL muscle activation from pre-intervention to post-intervention with the HAL gait training as compared to the treadmill gait training. In response to only HAL gait training, the CoV of RMS was higher, and the modified entropy was lower post-intervention than pre-intervention. Conclusions: Our results support the notion that HAL gait training has a positive benefit on motor output not only in the magnitude of SEMG generated but also the patterns of neural activation.

scholarly journals Influence of hybrid assistive limb gait training on spatial muscle activation patterns in spinal muscular atrophy type III

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 214
Author(s):  
Yuichi Nishikawa ◽  
Kohei Watanabe ◽  
Naoya Orita ◽  
Noriaki Maeda ◽  
Hiroaki Kimura ◽  
...  
Keyword(s):  
Spinal Muscular Atrophy ◽  
Muscle Activation ◽  
Muscular Atrophy ◽  
Training Session ◽  
Gait Training ◽  
Post Intervention ◽  
Spinal Muscular Atrophy Type ◽  
Type Iii ◽  
Hybrid Assistive Limb ◽  
Modified Entropy

Background: Despite the potential benefits, the effects of Hybrid Assistive Limb (HAL) gait training on changes in neuromuscular activation that accompany functional gains in individuals with spinal muscular atrophy (SMA) type III is not well known. In this article, we quantify the effects of HAL gait training on spatial muscle activity patterns in a patient with SMA type III using multi-channel surface electromyography (SEMG). Methods: A 21-years old male (168 cm, 47.8 kg) with spinal muscular atrophy type III, when diagnosed at 18-years old by genetic screening, participated in this case study. Although he presented with forearm distal muscle weakness, atrophy of the intrinsic muscles of the hand, and neuromuscular fatigue, his activities of daily living is independent. The patient underwent a separate, single 33-minute session of both HAL and treadmill gait training. To evaluate the coefficient of variation (CoV) of force and alterations in the SEMG spatial distribution patterns, modified entropy and CoV of root mean square (RMS) were calculated from the vastus lateralis (VL) muscle before and after the intervention of HAL and treadmill gait training. Each training session was separated by a period of one month to avoid cross-over effects. Results: There was a greater decrease in the ΔCoV of force and an increase in the magnitude of whole VL muscle activation from pre-intervention to post-intervention with the HAL gait training as compared to the treadmill gait training. In response to only HAL gait training, the CoV of RMS was higher, and the modified entropy was lower post-intervention than pre-intervention. Conclusions: Our results support the notion that HAL gait training has a positive benefit on motor output not only in the magnitude of SEMG generated but also the patterns of neural activation.

Gait-assisted exoskeletons for children with cerebral palsy or spinal muscular atrophy: A systematic review

2021 ◽  
pp. 1-16
Author(s):  
Carlos. Cumplido ◽  
Elena. Delgado ◽  
Jaime. Ramos ◽  
Gonzalo. Puyuelo ◽  
Elena. Garcés ◽  
...  
Keyword(s):  
Cerebral Palsy ◽  
Spinal Muscular Atrophy ◽  
Muscular Atrophy ◽  
Gait Training ◽  
Lower Limbs ◽  
Bibliographic Databases ◽  
Computer Search ◽  
Inclusion Criteria ◽  
Motor Disability ◽  
Common Causes

BACKGROUND: Cerebral Palsy (CP) and Spinal Muscular Atrophy (SMA) are common causes of motor disability in childhood. Gait exoskeletons are currently being used as part of rehabilitation for children with walking difficulties. OBJECTIVE: To assess the safety and efficacy and describe the main characteristics of the clinical articles using robot-assisted gait training (RAGT) with exoskeleton for children with CP or SMA. METHODS: A computer search was conducted in five bibliographic databases regarding clinical studies published in the last ten years. In order to be included in this review for further analysis, the studies had to meet the following criteria: (1) assess efficacy or safety of interventions; (2) population had to be children with CP or SMA aged between 3 and 14; (3) exoskeleton must be bilateral and assist lower limbs during walking. RESULTS: Twenty-one articles were selected, of which only five were clinical trials. 108 participants met the inclusion criteria for this study, all with a diagnosis of CP. The evidence level of the selected papers was commonly low. CONCLUSIONS: RAGT therapy seems to be safe for children with CP. However, further investigation is needed to confirm the results related to efficacy. There is no evidence of RAGT therapy for SMA children.

Hydrocephalus in Spinal Muscular Atrophy: A Case Report and Review of the Literature

2020 ◽  
Author(s):  
Jeetendra P. Sah ◽  
Aaron W. Abrams ◽  
Geetha Chari ◽  
Craig Linden ◽  
Yaacov Anziska
Keyword(s):  
Spinal Muscular Atrophy ◽  
Clinical Characteristics ◽  
Clinical Presentation ◽  
Muscular Atrophy ◽  
Communicating Hydrocephalus ◽  
Type I ◽  
Review Of The Literature ◽  
Radiographic Findings ◽  
Comprehensive Review ◽  
The Relationship

AbstractIn this article, we reported a case of spinal muscular atrophy (SMA) type I noted to have tetraventricular hydrocephalus with Blake's pouch cyst at 8 months of age following intrathecal nusinersen therapy. The association of hydrocephalus with SMA is rarely reported in the literature. Development of hydrocephalus after intrathecal nusinersen therapy is also reported in some cases, but a cause–effect relationship is not yet established. The aim of this study was to describe the clinical characteristics of a patient with SMA type I and hydrocephalus, to review similar cases reported in the literature, and to explore the relationship between nusinersen therapy and development of hydrocephalus. The clinical presentation and radiographic findings of the patient are described and a comprehensive review of the literature was conducted. The adverse effect of communicating hydrocephalus related to nusinersen therapy is being reported and the authors suggest carefully monitoring for features of hydrocephalus developing during the course of nusinersen therapy.

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