The Reliability of a Heuristic-Holistic Methodology for the Definition of Susceptibility to Destabilization—The Potential Sources of Uncertainty

Author(s):  
Celeste Jorge
2012 ◽  
Vol 9 (8) ◽  
pp. 9809-9845 ◽  
Author(s):  
A. Domeneghetti ◽  
S. Vorogushyn ◽  
A. Castellarin ◽  
B. Merz ◽  
A. Brath

Abstract. Comprehensive flood risk assessment studies should quantify the global uncertainty in flood hazard estimation, for instance by mapping inundation extents together with their confidence intervals. This appears of particular importance in case of flood hazard assessments along dike-protected reaches where the possibility of occurrence of dike failures may considerably enhance the uncertainty. We present a methodology to derive probabilistic flood maps in dike-protected flood prone areas, where several sources of uncertainty are taken into account. In particular, this paper focuses on a 50 km reach of River Po (Italy) and three major sources of uncertainty in hydraulic modelling and flood mapping: uncertainties in the (i) upstream and (ii) downstream boundary conditions, and (iii) uncertainties in dike failures. Uncertainties in the definition of upstream boundary conditions (i.e. design-hydrographs) are assessed by applying different bivariate copula families to model the frequency regime of flood peaks and volumes. Uncertainties in the definition of downstream boundary conditions are characterised by associating the rating-curve used as downstream boundary condition with confidence intervals which reflect discharge measurements errors and interpolation errors. The effects of uncertainties in boundary conditions and randomness of dike failures are assessed by means of the Inundation Hazard Assessment Model (IHAM), a recently proposed hybrid probabilistic-deterministic model that considers three different failure mechanisms: overtopping, piping and micro-instability due to seepage. The results of the study show that the IHAM-based analysis enables probabilistic flood hazard mapping and provides decision makers with a fundamental piece of information for devising and implementing flood risk mitigation strategies in the presence of various sources of uncertainty.


2019 ◽  
Vol 19 (1) ◽  
pp. 221-236 ◽  
Author(s):  
Pedro Folgueras ◽  
Sebastián Solari ◽  
Miguel Ángel Losada

Abstract. This paper presents a rational method for the selection of the most suitable directional sectors in the analysis of extreme wind loads on structures. It takes into consideration the main sources of uncertainty stemming from sector selection and leads to the definition of independent and statistically homogeneous directional sectors. This method is applied to the selection of directional sectors for the calculation of the design wind speed of a structure located at the mouth of the Río de la Plata. The results in the estimated reliability and costs were compared to those obtained with conventional engineering methods, revealing significant differences. It was found that the proposed method is a simple and objective tool for the selection of directional sectors, which comply with the working hypothesis of the directional models, and offers better guarantees for dimensioning than the use of more traditional engineering approaches for sectorial division.


Author(s):  
Joshua Daniel-Wariya ◽  
Lynn C. Lewis

This article describes the rationale, development, and implementation of a digital archival curriculum within the first-year composition program at Oklahoma State University. Such a curriculum helps students engage genuine inquiry to discover arguments rather than defend their existing beliefs. Analytic complexity and hidden information are offered as potential sources of uncertainty.


2018 ◽  
Author(s):  
Pedro Folgueras ◽  
Sebastián Solari ◽  
Miguel Ángel Losada

Abstract. This paper presents a rational method for the selection of the most suitable directional sectors in the analysis of extreme wind loads on structures. It takes into consideration the main sources of uncertainty stemming from sector selection, and leads to the definition of independent and statistically homogeneous directional sectors. This method is applied to the selection of directional sectors for the calculation of the design wind speed of a structure located at the mouth of the Río de la Plata. The results in the estimated reliability and costs were compared to those obtained with conventional engineering methods revealing significant differences. It was found that the proposed method is a simple and objective tool for the selection of directional sectors, which comply with the working hypothesis of the directional models and offers better guarantees for dimensioning than the use of more traditional engineering approaches for sectorial division.


Critical for identification of the potential sources of evidence in every network forensics investigation is the definition of the system architecture. The mobile network architecture has two main definitions, one concerning the network deployments before the 3GPP consolidated the mobile standardization, and one for the 3GPP networks onwards. Forensic investigators need to know both of them; the real-world network deployments include elements from different generations, so the uncovering of mobile network evidence requires knowledge of how every generation operates in practice. This chapter provides a detailed overview of the pre-3GPP network architecture, defining the critical elements for recognizing, acquiring, analyzing, and interpreting potential mobile network evidence.


2020 ◽  
Vol 11 ◽  
Author(s):  
Robin Minati ◽  
Claude Perreault ◽  
Pierre Thibault

The search for tumor-specific antigens (TSAs) has considerably accelerated during the past decade due to the improvement of proteogenomic detection methods. This provides new opportunities for the development of novel antitumoral immunotherapies to mount an efficient T cell response against one or multiple types of tumors. While the identification of mutated antigens originating from coding exons has provided relatively few TSA candidates, the possibility of enlarging the repertoire of targetable TSAs by looking at antigens arising from non-canonical open reading frames opens up interesting avenues for cancer immunotherapy. In this review, we outline the potential sources of TSAs and the mechanisms responsible for their expression strictly in cancer cells. In line with the heterogeneity of cancer, we propose that discrete families of TSAs may be enriched in specific cancer types.


2013 ◽  
Vol 17 (8) ◽  
pp. 3127-3140 ◽  
Author(s):  
A. Domeneghetti ◽  
S. Vorogushyn ◽  
A. Castellarin ◽  
B. Merz ◽  
A. Brath

Abstract. Comprehensive flood risk assessment studies should quantify the global uncertainty in flood hazard estimation, for instance by mapping inundation extents together with their confidence intervals. This appears of particular importance in the case of flood hazard assessments along dike-protected reaches, where the possibility of occurrence of dike failures may considerably enhance the uncertainty. We present a methodology to derive probabilistic flood maps in dike-protected flood prone areas, where several sources of uncertainty are taken into account. In particular, this paper focuses on a 50 km reach of River Po (Italy) and three major sources of uncertainty in hydraulic modelling and flood mapping: uncertainties in the (i) upstream and (ii) downstream boundary conditions, and (iii) uncertainties in dike failures. Uncertainties in the definition of upstream boundary conditions (i.e. design-hydrographs) are assessed through a copula-based bivariate analysis of flood peaks and volumes. Uncertainties in the definition of downstream boundary conditions are characterised by uncertainty in the rating curve with confidence intervals which reflect discharge measurement and interpolation errors. The effects of uncertainties in boundary conditions and randomness of dike failures are assessed by means of the Inundation Hazard Assessment Model (IHAM), a recently proposed hybrid probabilistic-deterministic model that considers three different dike failure mechanisms: overtopping, piping and micro-instability due to seepage. The results of the study show that the IHAM-based analysis enables probabilistic flood hazard mapping and provides decision-makers with a fundamental piece of information for devising and implementing flood risk mitigation strategies in the presence of various sources of uncertainty.


1966 ◽  
Vol 24 ◽  
pp. 3-5
Author(s):  
W. W. Morgan

1. The definition of “normal” stars in spectral classification changes with time; at the time of the publication of theYerkes Spectral Atlasthe term “normal” was applied to stars whose spectra could be fitted smoothly into a two-dimensional array. Thus, at that time, weak-lined spectra (RR Lyrae and HD 140283) would have been considered peculiar. At the present time we would tend to classify such spectra as “normal”—in a more complicated classification scheme which would have a parameter varying with metallic-line intensity within a specific spectral subdivision.


1975 ◽  
Vol 26 ◽  
pp. 21-26

An ideal definition of a reference coordinate system should meet the following general requirements:1. It should be as conceptually simple as possible, so its philosophy is well understood by the users.2. It should imply as few physical assumptions as possible. Wherever they are necessary, such assumptions should be of a very general character and, in particular, they should not be dependent upon astronomical and geophysical detailed theories.3. It should suggest a materialization that is dynamically stable and is accessible to observations with the required accuracy.


1979 ◽  
Vol 46 ◽  
pp. 125-149 ◽  
Author(s):  
David A. Allen

No paper of this nature should begin without a definition of symbiotic stars. It was Paul Merrill who, borrowing on his botanical background, coined the termsymbioticto describe apparently single stellar systems which combine the TiO absorption of M giants (temperature regime ≲ 3500 K) with He II emission (temperature regime ≳ 100,000 K). He and Milton Humason had in 1932 first drawn attention to three such stars: AX Per, CI Cyg and RW Hya. At the conclusion of the Mount Wilson Ha emission survey nearly a dozen had been identified, and Z And had become their type star. The numbers slowly grew, as much because the definition widened to include lower-excitation specimens as because new examples of the original type were found. In 1970 Wackerling listed 30; this was the last compendium of symbiotic stars published.


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