Targeting of Aerobic Glycolysis: An Emerging Therapeutic Approach Against Colon Cancer

2021 ◽  
pp. 225-244
Author(s):  
Pradip Kumar Jaiswara ◽  
Vishal Kumar Gupta ◽  
Shiv Govind Rawat ◽  
Rajan Kumar Tiwari ◽  
Pratishtha Sonker ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Therapeutic Approach ◽  
Aerobic Glycolysis

Probiotics in Colon Cancer: A Therapeutic Approach

2021 ◽  
pp. 421-434
Author(s):  
Anaga Nair ◽  
Eveline M. Anto ◽  
Jayamurthy Purushothaman
Keyword(s):  
Colon Cancer ◽  
Therapeutic Approach

scholarly journals Interleukin-22 promotes aerobic glycolysis associated with tumor progression via targeting hexokinase-2 in human colon cancer cells

Oncotarget ◽  
2017 ◽  
Vol 8 (15) ◽  
pp. 25372-25383 ◽  
Author(s):  
Yulin Liu ◽  
Fan Xiang ◽  
Yongming Huang ◽  
Liang Shi ◽  
Chaojie Hu ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Tumor Progression ◽  
Cancer Cells ◽  
Aerobic Glycolysis ◽  
Human Colon ◽  
Colon Cancer Cells ◽  
Human Colon Cancer ◽  
Hexokinase 2 ◽  
Interleukin 22 ◽  
Human Colon Cancer Cells

Colon Carcinoma in Childhood

PEDIATRICS ◽  
1971 ◽  
Vol 48 (2) ◽  
pp. 307-312
Author(s):  
Milton H. Donaldson ◽  
Peyton Taylor ◽  
Robert Rawitscher ◽  
John B. Sewell
Keyword(s):  
Colon Cancer ◽  
Surgical Treatment ◽  
Family History ◽  
Colon Carcinoma ◽  
Therapeutic Approach ◽  
Gastrointestinal Malignancy ◽  
History Of ◽  
Advanced Stages

Two cases of colon carcinoma in children without a family history of polyposis or gastrointestinal malignancy are reported. Details of the post-surgical treatment with 5-fluorouracil are stated, along with a brief recounting of the literature which served as a basis for the therapeutic approach utilized in these two patients. The tumor-free intervals of 14 and 20 months are impressive in view of the advanced stages of the lesions and, thus, suggest 5-FU should be utilized in children with colon cancer as it is in such adults.

Ferulic Acid and P-Coumaric Acid Inhibit Colon Cancer Growth Through GR/ lncRNA 495810/PKM2 Mediated Aerobic Glycolysis

2021 ◽  
Author(s):  
Kaili Cui ◽  
Haili Wu ◽  
Zhuoyu Li ◽  
Hanqing Li ◽  
Ruipeng Yang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Ferulic Acid ◽  
Aerobic Glycolysis ◽  
Cancer Growth ◽  
Coumaric Acid

scholarly journals IC261, a specific inhibitor of CK1δ/ε, promotes aerobic glycolysis through p53-dependent mechanisms in colon cancer

2020 ◽  
Vol 16 (5) ◽  
pp. 882-892
Author(s):  
Min Liu ◽  
Yuhan Hu ◽  
Shuya Lu ◽  
Manman Lu ◽  
Jingsong Li ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Aerobic Glycolysis ◽  
Specific Inhibitor

A Cancer Reprogramming Method Using MicroRNAs as a Novel Therapeutic Approach against Colon Cancer

2014 ◽  
Vol 22 (S3) ◽  
pp. 1394-1401 ◽  
Author(s):  
Susumu Miyazaki ◽  
Hirofumi Yamamoto ◽  
Norikatsu Miyoshi ◽  
Xin Wu ◽  
Hisataka Ogawa ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Therapeutic Approach ◽  
Novel Therapeutic

scholarly journals Tiliroside Ameliorates Ulcerative Colitis by Restoring the M1/M2 Macrophage Balance via the HIF-1α/glycolysis Pathway

2021 ◽  
Vol 12 ◽  
Author(s):  
Hongda Zhuang ◽  
Qi Lv ◽  
Chao Zhong ◽  
Yaru Cui ◽  
Luling He ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Therapeutic Approach ◽  
Activity Index ◽  
Aerobic Glycolysis ◽  
Macrophage Polarization ◽  
M2 Macrophage ◽  
Inflammatory Status ◽  
Promising Therapeutic Approach ◽  
Anti Inflammatory

Macrophages polarized to different phenotypes critically contribute to colitis development by coordinating inflammatory and anti-inflammatory processes. Herein, targeting the balance between the pro-inflammatory M1 and the anti-inflammatory M2 macrophage phenotypes can be a novel therapeutic approach for colitis. In the present study, we firstly demonstrated that tiliroside possessed the ability to alleviate the clinical symptoms of colitis as evidenced by decreased disease activity index (DAI) scores, longer colon length, reduced myeloperoxidase (MPO) activity, and improvement of colonic pathological damage in vivo. Furthermore, we showed that tiliroside modulated the balance between M1 and M2 macrophages toward a more anti-inflammatory status in colonic lamina propria but has little effect on the T cell population and epithelial barrier function in colitis mice. The macrophage depletion study further showed the protective effect of tiliroside was macrophage dependent in vivo. Mechanistically, our study demonstrated that tiliroside regulated cellular metabolism by inhibiting aerobic glycolysis in LPS and IFNγ stimulated macrophages. At the molecular level, tiliroside facilitated the proteasomal degradation of HIF-1α and downregulated mRNA expressions of HIF-1α dependent glycolytic enzymes in macrophages. Collectively, our data highlight the aberrant M1/M2 macrophage polarization in the initiation and development of ulcerative colitis and put forth the stage for considering tiliroside as a metabolic regulator in reprogramming macrophage polarization, which may serve as a promising therapeutic approach for treatment of inflammation-associated and metabolic disorders.

scholarly journals Tumor Initiating Cells and Chemoresistance: Which Is the Best Strategy to Target Colon Cancer Stem Cells?

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Emanuela Paldino ◽  
Valentina Tesori ◽  
Patrizia Casalbore ◽  
Antonio Gasbarrini ◽  
Maria Ausiliatrice Puglisi
Keyword(s):  
Stem Cells ◽  
Colon Cancer ◽  
Cancer Stem Cells ◽  
Anticancer Agents ◽  
Cancer Biology ◽  
Residual Disease ◽  
Aerobic Glycolysis ◽  
Cell Subpopulation ◽  
Metastatic Colon Cancer ◽  
Tumor Initiating Cells

There is an emerging body of evidence that chemoresistance and minimal residual disease result from selective resistance of a cell subpopulation from the original tumor that is molecularly and phenotypically distinct. These cells are called “cancer stem cells” (CSCs). In this review, we analyze the potential targeting strategies for eradicating CSCs specifically in order to develop more effective therapeutic strategies for metastatic colon cancer. These include induction of terminal epithelial differentiation of CSCs or targeting some genes expressed only in CSCs and involved in self-renewal and chemoresistance. Ideal targets could be cell regulators that simultaneously control the stemness and the resistance of CSCs. Another important aspect of cancer biology, which can also be harnessed to create novel broad-spectrum anticancer agents, is the Warburg effect, also known as aerobic glycolysis. Actually, little is yet known with regard to the metabolism of CSCs population, leaving an exciting unstudied avenue in the dawn of the emerging field of metabolomics.

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