Monocot ABC Transporters

2014 ◽  
pp. 203-217
Author(s):  
YanXia Xu ◽  
YanHua Qi
Keyword(s):  
Abc Transporters

Comparison of the effect of ABC-transporters inhibitor verapamil at different ways of intake to the german сосkroach Blattella germanica (l.) (Blattodea: Ectobiidae)

2019 ◽  
pp. 53-59
Author(s):  
Olga Yurevna Eremina ◽  
◽  
Veronika Valentinovna Olifer ◽  
Yuliya Vladimirovna Lopatina ◽  
◽  
...  
Keyword(s):  
Abc Transporters ◽  
Blattella Germanica

Modulation of Expression and Activity of ABC Transporters by the Phytoestrogen Genistein. Impact on Drug Disposition

2016 ◽  
Vol 23 (13) ◽  
pp. 1370-1389 ◽  
Author(s):  
Juan Pablo Rigalli ◽  
Nadia Ciriaci ◽  
Aldo Domingo Mottino ◽  
Viviana Alicia Catania ◽  
María Laura Ruiz
Keyword(s):  
Abc Transporters ◽  
Drug Disposition ◽  
Expression And Activity

Current Understanding of Interactions between Nanoparticles and ABC Transporters in Cancer Cells

2019 ◽  
Vol 25 (42) ◽  
pp. 5930-5944 ◽  
Author(s):  
Jian Yin ◽  
Xudong Deng ◽  
Jie Zhang ◽  
Jun Lin
Keyword(s):  
Abc Transporters ◽  
Recent Literature ◽  
Current Knowledge ◽  
Major Elements ◽  
Inhibitory Effects ◽  
Potential Toxicity ◽  
Central Nervous System Disorders ◽  
Extensive Search ◽  
Potential Interactions ◽  
Effective Cancer Therapy

Background: ATP-binding cassette (ABC) transporters-mediated multidrug resistance (MDR) remains the major obstacle for effective cancer therapy. Nanoparticles (NPs)-based delivery systems are promising to overcome MDR, but only a few of them have been accepted for clinical treatment, which should be due to their insufficient transportation and potential toxicity. In this respect, more and more attentions are being attracted on the interactions between NPs and ABC transporters, which hold a key role in the treatment of MDR cancer and the toxicity of NPs. However, there are no systematic reviews about such interactions, especially about their corresponding mechanism. Methods: We undertook extensive search of PubMed databases for peer-reviewed literatures using focused review questions. The retrieved papers were mostly published within the 5 years (84 of 104) and all with an impact factor above 2. First, this review focused on the current knowledge of ABC transporters involved in MDR and their inhibitors. Then, we reviewed the most recent literature about the inhibitory effects of organic NPs’ excipients on ABC transporters and the direct interactions of inorganic NPs with ABC transporters. The major elements of obtained papers were described and classified depending on the structure of NPs. Results: Both organic and inorganic NPs can inhibit the function of ABC transporters, but based on different mechanisms. The effects of organic NPs are caused by several excipients like surfactants, polymers, lipids and cyclodextrin. Meanwhile, inorganic NPs usually act as the substrates of ABC transporters and competitively inhibit the efflux of drugs. These phenomena are interesting and worth investigating. Conclusion: The finding of this review confirmed the potential interactions between NPs and ABC transporters. These phenomena are interesting and worth investigating, and a knowledge of related mechanism would not only be important for the clinical therapies toward overcoming cancer MDR, but also help the treatment of other diseases like tuberculosis, AIDS, and central nervous system disorders, whose drugresistance was also related to ABC transporter-mediated efflux.

Modulation of Hepatic MRP3/ABCC3 by Xenobiotics and Pathophysiological Conditions: Role in Drug Pharmacokinetics

2019 ◽  
Vol 26 (7) ◽  
pp. 1185-1223 ◽  
Author(s):  
Carolina I. Ghanem ◽  
Jose E. Manautou
Keyword(s):  
Abc Transporters ◽  
Basolateral Membrane ◽  
Clinical Use ◽  
Nucleotide Analogs ◽  
Synthetic Drugs ◽  
The Family ◽  
Hepatic Transporter ◽  
Related Proteins ◽  
Drug Pharmacokinetics ◽  
Conjugated Metabolites

Liver transporters play an important role in the pharmacokinetics and disposition of pharmaceuticals, environmental contaminants, and endogenous compounds. Among them, the family of ATP-Binding Cassette (ABC) transporters is the most important due to its role in the transport of endo- and xenobiotics. The ABCC sub-family is the largest one, consisting of 13 members that include the cystic fibrosis conductance regulator (CFTR/ABCC7); the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) and the multidrug resistanceassociated proteins (MRPs). The MRP-related proteins can collectively confer resistance to natural, synthetic drugs and their conjugated metabolites, including platinum-containing compounds, folate anti-metabolites, nucleoside and nucleotide analogs, among others. MRPs can be also catalogued into "long" (MRP1/ABCC1, -2/C2, -3/C3, -6/C6, and -7/C10) and "short" (MRP4/C4, -5/C5, -8/C11, -9/C12, and -10/C13) categories. While MRP2/ABCC2 is expressed in the canalicular pole of hepatocytes, all others are located in the basolateral membrane. In this review, we summarize information from studies examining the changes in expression and regulation of the basolateral hepatic transporter MPR3/ABCC3 by xenobiotics and during various pathophysiological conditions. We also focus, primarily, on the consequences of such changes in the pharmacokinetic, pharmacodynamic and/or toxicity of different drugs of clinical use transported by MRP3.

PET Tracers for Imaging of ABC Transporters at the Blood-Brain Barrier: Principles and Strategies

2016 ◽  
Vol 22 (38) ◽  
pp. 5779-5785 ◽  
Author(s):  
Gert Luurtsema ◽  
Philip Elsinga ◽  
Rudi Dierckx ◽  
Ronald Boellaard ◽  
Aren Waarde
Keyword(s):  
Blood Brain Barrier ◽  
Abc Transporters ◽  
Brain Barrier ◽  
Pet Tracers ◽  
Blood Brain

ABC Transporters in the Development of Multidrug Resistance in Cancer Therapy

2016 ◽  
Vol 22 (30) ◽  
pp. 4705-4716 ◽  
Author(s):  
Angelika Dlugosz ◽  
Anna Janecka
Keyword(s):  
Multidrug Resistance ◽  
Cancer Therapy ◽  
Abc Transporters

Effect of Neuroinflammation on ABC Transporters: Possible Contribution to Refractory Epilepsy

2018 ◽  
Vol 17 (10) ◽  
pp. 728-735 ◽  
Author(s):  
Xiaolin Deng ◽  
Yangmei Xie ◽  
Yinghui Chen
Keyword(s):  
Antiepileptic Drugs ◽  
Abc Transporters ◽  
Refractory Epilepsy ◽  
Vascular Endothelial Cells ◽  
Efflux Transporters ◽  
Vascular Endothelial ◽  
Intracellular Signalling Pathways ◽  
The Brain ◽  
Transporter Expression

Background & Objective: Epilepsy is a common and serious chronic neurological disorder that is mainly treated with antiepileptic drugs. Although current antiepileptic drugs used in clinical practice have advanced to the third generation, approximately one-third of patients are refractory to these treatments. More efficacious treatments for refractory epilepsy are therefore needed. A better understanding of the mechanism underlying refractory epilepsy is likely to facilitate the development of a more effective therapy. The abnormal expression and/or dysfunction of efflux transporters, particularly ABC transporters, might contribute to certain cases of refractory epilepsy. Inflammation in the brain has recently been shown to regulate the expression and/or function of ABC transporters in the cerebral vascular endothelial cells and glia of the blood-brain barrier by activating intracellular signalling pathways. Conclusion: Therefore, in this review, we will briefly summarize recent research advances regarding the possible role of neuroinflammation in regulating ABC transporter expression in epilepsy.

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