Surgical Approaches to Early-Stage Renal Cell Carcinoma

Kidney Cancer ◽  
2015 ◽  
pp. 137-156
Author(s):  
Daniel J. Canter ◽  
David B. Cahn ◽  
Robert G. Uzzo
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Early Stage ◽  
Surgical Approaches

scholarly journals Systematic Review of Contemporary Evidence for the Management of T1 Renal Cell Carcinoma: What IRs Need to Know for Kidney Cancer Tumor Boards

2019 ◽  
Vol 36 (03) ◽  
pp. 194-202 ◽  
Author(s):  
Julie Cronan ◽  
Sean Dariushnia ◽  
Zachary Bercu ◽  
Robert Mitchell Ermentrout ◽  
Bill Majdalany ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Early Stage ◽  
The United States ◽  
Cross Sectional ◽  
Increased Risk ◽  
Tumor Boards ◽  
Cancer Tumor ◽  
Cross Sectional Imaging

AbstractRenal cell carcinoma is a relatively common malignancy, with 60 to 70 thousand cases a year in the United States alone. Increased utilization of cross-sectional imaging has led to an increase in the number of early renal cell cancers seen by the medical establishment. In addition, certain patient populations have an increased risk of developing kidney cancers which may mandate aggressive screening protocols. This article discusses the epidemiology of renal cell cancers; discusses the current management guidelines from multiple specialty societies; discusses some of the surgical and interventional techniques used in the treatment of such lesions; and provides a review of the literature regarding treatments of early-stage renal cell cancers.

scholarly journals Combined Metabolomics and Genome-Wide Transcriptomics Analyses Show Multiple HIF1α-Induced Changes in Lipid Metabolism in Early Stage Clear Cell Renal Cell Carcinoma

2020 ◽  
Vol 13 (2) ◽  
pp. 177-185 ◽  
Author(s):  
Johannes C. van der Mijn ◽  
Leiping Fu ◽  
Francesca Khani ◽  
Tuo Zhang ◽  
Ana M. Molina ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Lipid Metabolism ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Early Stage ◽  
Cell Renal Cell Carcinoma ◽  
Genome Wide ◽  
Induced Changes

Biomarkers of renal cell carcinoma

2019 ◽  
Vol 17 (4) ◽  
pp. 45-51
Author(s):  
S. A. Aschuba ◽  
E. S. Solomko ◽  
D. A. Khochenkov ◽  
A. A. Osipova ◽  
E. V. Stepanova
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Early Stage ◽  
Metastatic Potential ◽  
Common Disease ◽  
Non Invasive ◽  
Cancer Early Detection ◽  
Appropriate Treatment ◽  
Minimally Invasive Methods

Renal cell carcinoma (RCC) ranks first in mortality among urogenital tumors and is the most common disease after prostate and bladder cancer. Early detection of RCC allows immediately undertaking appropriate treatment, which significantly increases the survival of patients. In the case of the asymptomatic RCC, timely diagnosis in the early stages is usually difficult. To date, the problem of searching for molecular markers of clear cell RCC, which allows to determine the stage, metastatic potential and prognosis of disease, or select a treatment regimen remains topical. Of particular interest are early-stage biomarkers of RCC and its metastatic potential, as well as markers that can be obtained by non-invasive or minimally invasive methods. This review presents modern methods for diagnosing RCC using biomarkers.

Incidence of benign versus malignant renal tumors in selected studies.

2012 ◽  
Vol 30 (5_suppl) ◽  
pp. 357-357 ◽  
Author(s):  
Paul Russo ◽  
Robert G. Uzzo ◽  
William Thomas Lowrance ◽  
Aviva Asnis-Alibozek ◽  
Norman David LaFrance ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Malignant Tumors ◽  
Early Stage ◽  
Renal Tumors ◽  
Benign Tumors ◽  
Stage Migration ◽  
Renal Masses ◽  
Definitive Method

357 Background: Use of cross-sectional imaging has increased the detection rate for small renal tumors; more patients now present with early-stage renal cell carcinoma (RCC) or benign or indolent renal masses. Histopathology after surgical resection is the definitive method for characterizing renal tumors. Stage migration of renal masses creates uncertainty about the percentage of resected masses that will be benign vs malignant. We sought to better define these proportions through a targeted review of the literature. Methods: PubMed/select congresses were searched to identify the histologic classification of renal masses in a representative sample from the contemporary literature: [search] incidence AND (renal cell carcinoma AND benign); incidence AND (renal tumor AND benign); percentage AND (renal cell carcinoma AND benign); limit: 2003–2011. Results: Most representative studies included procedures conducted in the mid-1990s to the mid-to-late 2000s. Studies origin was US (n=8), Korea (n=3), China, Japan, Germany, Austria, Australia, and multisite (Israel/France/US; all n=1). Only 8 studies had n≥500 (range, 70–10,404). The proportion of benign masses are shown (see Table); half of the studies reported values between 16% and 17%. The majority found that benign tumors were more likely to be smaller in size (<4 or <7 cm) than malignant tumors. 11 studies reported the RCC subtype (% clear cell range, 46%–83%). Conclusions: Benign renal tumors occur ~15% of the time and are more prevalent among small masses. Nearly 25% of resected lesions are benign or indolent and may not require surgery. Preoperative discrimination of more aggressive renal masses would be an important clinical advance that could improve clinicians’ diagnostic confidence and guide patient management. Funding: Wilex AG/IBA Molecular. [Table: see text]

scholarly journals Hypoxia-induced overexpression of stanniocalcin-1 is associated with the metastasis of early stage clear cell renal cell carcinoma

2015 ◽  
Vol 13 (1) ◽  
pp. 56 ◽  
Author(s):  
Xin Ma ◽  
Liangyou Gu ◽  
Hongzhao Li ◽  
Yu Gao ◽  
Xintao Li ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clear Cell ◽  
Early Stage ◽  
Cell Renal Cell Carcinoma
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