The Combined Use of Enhanced Stromal Vascular Fraction and Platelet-Rich Plasma Improves Fat Grafting Maintenance in Breast Reconstruction: A Comparative Translational Study

2016 ◽  
pp. 273-287 ◽  
Author(s):  
Valerio Cervelli ◽  
Pietro Gentile
Keyword(s):  
Breast Reconstruction ◽  
Platelet Rich Plasma ◽  
Stromal Vascular Fraction ◽  
Fat Grafting ◽  
Translational Study ◽  
Combined Use

scholarly journals P.R.L. Platelet Rich Lipotransfert: Our Experience and Current State of Art in the Combined Use of Fat and PRP

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
V. Cervelli ◽  
I. Bocchini ◽  
C. Di Pasquali ◽  
B. De Angelis ◽  
G. Cervelli ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Platelet Rich Plasma ◽  
Soft Tissue Defect ◽  
Fat Grafting ◽  
Promising Alternative ◽  
Hemifacial Atrophy ◽  
Innovative Methods ◽  
Current State ◽  
Combined Use ◽  
Natural Healing

The authors report their experience about the use of P.R.L. PLATELET RICH LIPOTRANSFERT method (platelet rich plasma mixed fat grafting) in 223 patients affected by soft tissue defects (ulcers, Romberg syndrome, Hemifacial atrophy, loss of substance, and signs of aging). This paper introduces the reader to PRP therapy and reviews the current literature on this emerging treatment modality, showing at the current clinical use of PRP in plastic and reconstructive surgery, with description of innovative methods and future prospects. This technique provides a promising alternative to surgery by promoting safe and natural healing. Here recent studies concerning the use of PRP in the treatment of chronic ulcers and soft tissue defect are reviewed.

scholarly journals Breast Reconstruction with Enhanced Stromal Vascular Fraction Fat Grafting

2015 ◽  
Vol 3 (6) ◽  
pp. e406 ◽  
Author(s):  
Pietro Gentile ◽  
Maria Giovanna Scioli ◽  
Augusto Orlandi ◽  
Valerio Cervelli
Keyword(s):  
Breast Reconstruction ◽  
Stromal Vascular Fraction ◽  
Fat Grafting

scholarly journals Autologous stromal vascular fraction cells combined with platelet-rich plasma for androgenic alopecia treatment: a case series

F1000Research ◽  
2021 ◽  
Vol 10 ◽  
pp. 408
Author(s):  
Fonny Josh ◽  
Tomie Hermawan Soekamto ◽  
Muhammad Faruk
Keyword(s):  
Platelet Rich Plasma ◽  
Treatment Options ◽  
Stromal Vascular Fraction ◽  
Case Series ◽  
Androgenic Alopecia ◽  
Case Presentation ◽  
Therapeutic Outcomes ◽  
Multipotent Cells ◽  
Combined Use

Background: Stromal vascular fraction cells (SVFs), which can be produced using a mechanical or digestive enzymatic process, are heterogeneous cells with the potential to grow hair in androgenic alopecia patients. Platelet-rich plasma (PRP) is an autologous cell source that is widely used to treat androgenic alopecia. However, the combined use of PRP and SVFs to treat alopecia is rarely reported. Case presentation: This case series describes three cases of androgenic alopecia, including a32-year-old male, a 43-year-old male, and a 65-year-old male. Androgenic alopecia in these patients was treated by injecting the bald area of the scalp with local autologous PRP combined with SVFs. Follow-up was performed 1–3 months after treatment, which showed good results. The hair grew denser, with increased thickness for each strand. The hair pull test revealed that the hair remained intact. Conclusion: The combination of PRP and SVFs affected all cycles of the hair growth process. SVFs are multipotent cells with the potential to become antioxidant, anti-inflammatory, or anti-fibrotic cells. SVFs can regenerate cells that secrete the growth factors, that are essential for angiogenesis, which can improve therapeutic outcomes. This case series will enrich the existing literature by expanding available treatment options for androgenic alopecia.

scholarly journals Engineered Fat Graft Enhanced with Adipose-Derived Stromal Vascular Fraction Cells for Regenerative Medicine: Clinical, Histological and Instrumental Evaluation in Breast Reconstruction

2019 ◽  
Vol 8 (4) ◽  
pp. 504 ◽  
Author(s):  
Pietro Gentile ◽  
Donato Casella ◽  
Enza Palma ◽  
Claudio Calabrese
Keyword(s):  
Breast Reconstruction ◽  
Preoperative Evaluation ◽  
Three Dimensional ◽  
Stromal Vascular Fraction ◽  
Fat Graft ◽  
Control Group ◽  
Study Group ◽  
Fat Tissue ◽  
Calvarial Defects

The areas in which Stromal Vascular Fraction cells (SVFs) have been used include radiotherapy based tissue damage after mastectomy, breast augmentation, calvarial defects, Crohn’s fistulas, and damaged skeletal muscle. Currently, the authors present their experience using regenerative cell therapy in breast reconstruction. The goal of this study was to evaluate the safety and efficacy of the use of Engineered Fat Graft Enhanced with Adipose-derived Stromal Vascular Fraction cells (EF-e-A) in breast reconstruction. 121 patients that were affected by the outcomes of breast oncoplastic surgery were treated with EF-e-A, comparing the results with the control group (n = 50) treated with not enhanced fat graft (EF-ne-A). The preoperative evaluation included a complete clinical examination, a photographic assessment, biopsy, magnetic resonance (MRI) of the soft tissue, and ultrasound (US). Postoperative follow-up took place at two, seven, 15, 21, 36 weeks, and then annually. In 72.8% (n = 88) of breast reconstruction treated with EF-e-A, we observed a restoration of the breast contour and an increase of 12.8 mm in the three-dimensional volume after 12 weeks, which was only observed in 27.3% (n = 33) of patients in the control group that was treated with EF-ne-A. Transplanted fat tissue reabsorption was analyzed with instrumental MRI and US. Volumetric persistence in the study group was higher (70.8%) than that in the control group (41.4%) (p < 0.0001 vs. control group). The use of EF-e-A was safe and effective in this series of treated cases.

scholarly journals The Future of Fat Grafting

2021 ◽  
Vol 41 (Supplement_1) ◽  
pp. S69-S74
Author(s):  
Summer E Hanson
Keyword(s):  
Adipose Tissue ◽  
Breast Reconstruction ◽  
Fat Grafting ◽  
The Other ◽  
Special Topic ◽  
Autologous Fat Grafting ◽  
Upper Arm ◽  
Future Directions ◽  
Autologous Fat ◽  
The Face

Abstract One of the earliest reported cases of autologous fat grafting (AFG) was by Neuber in 1893 and consisted of the transfer of small lobules of fat from the upper arm for cicatrical depression of the face. He advocated the use of smaller grafts, noting that pieces larger than the size of a bean would form cysts. In 1895, Czerny excised a lumbar lipoma and transplanted it to the chest for breast reconstruction. Since these early reports, the knowledge base around AFG has expanded exponentially, as illustrated by the other papers within this special topic. As we embark on the next phase of AFG in the clinical setting, there are several directions which are near-clinical translation. This paper discusses future directions in fat grafting that build on optimization of our current techniques as clinical indications expand, such as supplementing purified lipoaspirate and the associated regulatory burden, or deconstructing adipose tissue to selectively use adipose graft components for a variety of regenerative indications.

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