Interval Regularization Approach to the Firordt Method of the Spectrophotometric Analysis of the Non-separated Mixtures

2016 ◽  
pp. 201-208 ◽  
Author(s):  
Valentin Golodov
Keyword(s):  
Spectrophotometric Analysis

SPECTROPHOTOMETRIC ANALYSIS AND FRACTURE RESISTANCE OF SUPER AND ULTRA TRANSLUCENCY ZIRCONIA VERSUS LITHIUM DISILICAET GLASS CERAMICS

2017 ◽  
Vol 63 (2) ◽  
pp. 1647-1652
Author(s):  
Sara Telyani ◽  
Esam Osman ◽  
Mohammad Rayyan ◽  
Ehab Farghaly ◽  
Ghada Hamza
Keyword(s):  
Fracture Resistance ◽  
Glass Ceramics ◽  
Spectrophotometric Analysis

scholarly journals Quality assessment of brands of erythromycin stearate tablets marketed in Abuja, Nigeria

2020 ◽  
Vol 17 (1) ◽  
pp. 29-33
Author(s):  
Kudirat B. Mustapha ◽  
Marlene D. Ekpo ◽  
Isa H. Galadima ◽  
Rukaiyatu A. Kirim ◽  
Olubukola A. Odeniran ◽  
...  
Keyword(s):  
Quality Assessment ◽  
Quality Evaluation ◽  
Hardness Test ◽  
Spectrophotometric Analysis ◽  
Assessment Study ◽  
Uniformity Test ◽  
Quality Assessment Study ◽  
Percentage Weight ◽  
Pharmaceutical Industries ◽  
Erythromycin Stearate

Erythromycin is one of the most frequently prescribed antibiotics. With the increasing number of pharmaceutical industries, the possibility of  purchasing a substandard product is on the high side. This makes it necessary to subject various commercially produced brands of erythromycin to quality evaluation in order to ascertain the quality. In this quality assessment study, six (6) brands of erythromycin tablets were subjected to physicochemical assay using standard physical methods and UV/VIS spectrophotometric analysis at 480 nm. The calibration curve for reference erythromycin was linear over a concentration range of 10-100 μg/ml with a correlation coefficient (R2) of 0.999. All the brands had standard deviation of weight greater than ±5 for the weight uniformity test. 66.67% of the brands passed the test for content of active ingredient. 83.33% of the brands examined passed the hardness test. All the brands failed the friability test because the percentage weight loss are greater than 1% as specified in the official book. Keywords: Erythromycin stearate; Tablets; Brands; Pharmaceutical Industries

scholarly journals UV SPECTROPHOTOMETRIC ANALYSIS AND VALIDATION OF OSELTAMIVIRPHOSPHATE IN PURE AND PHARMACEUTICAL FORMULATION

2020 ◽  
pp. 111-114 ◽  
Author(s):  
SACHIN A. YANJANE ◽  
SHRISHAIL M. GHURGHURE ◽  
VINOD K. MATOLE
Keyword(s):  
Spectrophotometric Method ◽  
Spectrophotometric Analysis ◽  
Pharmaceutical Formulation ◽  
Ich Guidelines ◽  
Highly Sensitive ◽  
Double Beam ◽  
Recovery Study ◽  
Uv Visible ◽  
Oseltamivir Phosphate ◽  
Simple Economic

Objective: A new, simple, economical, precise, sensitive, linear, accurate, rapid UV spectrophotometric method has been developed for the estimation of Oseltamivir Phosphate in pure form and pharmaceutical formulation. Methods: This UV method was developed using Methanol as a solvent. In the present method, the wavelength selected for analysis was 218 nm. UV-Visible double beam spectrophotometer (Systronic 2201) was used to carry out spectral analysis. The ICH guidelines were used to validate the method. Results: The method was validated for linearity, range, accuracy, precision, robustness, LOD and LOQ. Linearity was found in the range of 10-50µg/ml. Accuracy was performed by using a recovery study. The amount of drug recovered was found to be in the range of 99.01-100.1%. The % RSD value was found to be less than 2. Conclusion: The developed UV spectrophotometric method was found to be simple, economic, sensitive, easy, accurate, linear, specific and highly sensitive and can be used for routine estimation of Oseltamivir Phosphate.

Plasma thiol/disulphide homeostasis changes in patients with restless legs syndrome

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Ertan Kucuksayan ◽  
Serkan Ozben ◽  
Selma Topaloglu Tuac ◽  
Mesrure Koseoglu ◽  
Ozcan Erel ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Restless Legs Syndrome ◽  
Rating Scales ◽  
Spectrophotometric Analysis ◽  
Healthy Controls ◽  
Restless Legs ◽  
Severity Rating ◽  
Total Thiol ◽  
Disease Rating ◽  
Positive Correlations

Abstract Objectives Restless legs syndrome (RLS) is a common neurological condition. Oxidative stress plays an important role in its pathogenesis. Thiol-disulphide homeostasis (TDH) is a new biomarker of oxidative stress. We studied plasma TDH to determine whether TDH could be used as a new biomarker for RLS and evaluated correlations between TDH and various disease severity rating scales. Methods A total of 25 RLS patients and 25 healthy controls were included into the study. TDH status was determined using an automated spectrophotometric analysis method and correlations were analyzed between the TDH status and various disease rating scales in the RLS patients. Results Plasma total (401 ± 27 μmol/L) and native thiol (354 ± 30 μmol/L) levels were significantly lower, but disulphide level (24 ± 6 μmol/L) was significantly (<0.0001) higher in the RLS patients compared to the controls (455 ± 36, 424 ± 37, 15 ± 5 μmol/L, respectively). The disulphide/native thiol and disulphide/total thiol ratios increased, in contrast, native thiol/total thiol ratio decreased significantly in the RLS patients compared to the healthy controls (<0.0001). The disulphide levels correlated positively with age and various rating scores of the RLS patients. International Restless Legs Syndrome Study Group (IRLSSG) rating score and age correlated negatively with the total and native thiol levels. Conclusions Our findings indicate increased oxidative stress in the RLS patients reflected by decreased native and total thiol, and increased disulphide levels and positive correlations between the disulphide levels and various rating scores. We suggest dynamic TDH status to be used as a novel biomarker for the diagnosis and follow-up of the RLS patients.

scholarly journals Assessment of Mini-Tablets Coating Uniformity as a Function of Fluid Bed Coater Inlet Conditions

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 746
Author(s):  
Magdalena Turk ◽  
Rok Šibanc ◽  
Rok Dreu ◽  
Maja Frankiewicz ◽  
Małgorzata Sznitowska
Keyword(s):  
Coating Layer ◽  
Spectrophotometric Analysis ◽  
Material Distribution ◽  
Spray Chamber ◽  
Colorimetric Analysis ◽  
Swirl Generator ◽  
Coating Uniformity ◽  
Fluid Bed ◽  
Inlet Conditions

This study concerned the quality of mini-tablets’ coating uniformity obtained by either the bottom spray chamber with a classical Wurster distributor (CW) or a swirl distributor (SW). Mini-tablets with a diameter of 2.0, 2.5, and 3.0 mm were coated with hypromellose using two different inlet air distributors as well as inlet airflow rates (130 and 156 m3/h). Tartrazine was used as a colorant in the coating layer and the coating uniformity was assessed by spectrophotometric analysis of solutions obtained after disintegration of the mini-tablets (n = 100). Higher uniformity of coating material distribution among the mini-tablets was observed in the case of SW distributor, even for the biggest mini-tablets (d = 3.0 mm), with an RSD no larger than 5.0%. Additionally, coating thickness was evaluated by colorimetric analysis (n = 1000), using a scanner method, and expressed as a hue value. A high correlation (R = 0.993) between inter-tablet variability of hue and UV-Vis results was obtained. Mini-tablets were successfully coated in a fluid bed system using both a classical Wurster distributor as well as a swirl generator. However, regardless of the mini-tablets’ diameter, better film uniformity was achieved in the case of a distributor with a swirl generator.

scholarly journals Paving the Way to Food Grade Analytical Chemistry: Use of a Natural Deep Eutectic Solvent to Determine Total Hydroxytyrosol and Tyrosol in Extra Virgin Olive Oils

Foods ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 677
Author(s):  
Vito Michele Paradiso ◽  
Francesco Longobardi ◽  
Stefania Fortunato ◽  
Pasqua Rotondi ◽  
Maria Bellumori ◽  
...  
Keyword(s):  
Analytical Chemistry ◽  
Acid Hydrolysis ◽  
Virgin Olive Oil ◽  
Deep Eutectic Solvent ◽  
Spectrophotometric Analysis ◽  
Health Claim ◽  
Food Grade ◽  
Olive Oils ◽  
Natural Deep Eutectic Solvent ◽  
The Way

Extra virgin olive oil (EVOO) is well known for containing relevant amounts of healthy phenolic compounds. The European Food Safety Authority (EFSA) allowed a health claim for labelling olive oils containing a minimum amount of hydroxytyrosol (OHTyr) and its derivatives, including tyrosol (Tyr). Therefore, harmonized and standardized analytical protocols are required in support of an effective application of the health claim. Acid hydrolysis performed after extraction and before chromatographic analysis has been shown to be a feasible approach. Nevertheless, other fast, green, and easy methods could be useful for on-site screening and monitoring applications. In the present research, a natural deep eutectic solvent (NADES) composed of lactic acid and glucose was used to perform a liquid/liquid extraction on EVOO samples, followed by UV-spectrophotometric analysis. The spectral features of the extracts were related with the content of total OHTyr and Tyr, determined by the acid hydrolysis method. The second derivative of spectra allowed focusing on three single wavelengths (i.e., 299 nm, 290 nm, and 282 nm) significantly related with total OHTyr, total Tyr, and their sum, respectively. In particular, the sum of OHTyr and Tyr could be determined with a root mean square error of prediction of 29.5 mg kg−1, while the limits of quantitation and detection were respectively 11.8 and 4.9 mg kg−1. The proposed method, therefore, represents an easy screening tool, with the use of a green, food-derived solvent, and could be considered as an attempt to pave the way for food grade analytical chemistry.

scholarly journals Spectrophotometric Analysis of Protein Contents in Twenty Five Accessions of Ginger Rhizomes from Kumaun and Garhwal Regions of Uttarakhand, India

2016 ◽  
Vol 28 (7) ◽  
pp. 1498-1500
Author(s):  
Jyotsna Dhanik ◽  
Ankita Verma ◽  
Neelam Arya ◽  
Vivekanand
Keyword(s):  
Spectrophotometric Analysis

Analysis of Synthetic Fibers by Diamond Cell and Sapphire Cell Infrared Spectrophotometry

1978 ◽  
Vol 61 (3) ◽  
pp. 526-532
Author(s):  
Leonard K Read ◽  
Robert J Kopec
Keyword(s):  
Sample Preparation ◽  
Analytical Methods ◽  
Nondestructive Method ◽  
Spectrophotometric Analysis ◽  
Infrared Spectrophotometry ◽  
Generic Type ◽  
Synthetic Fibers ◽  
Fiber Sample

Abstract A rapid, simple, and nondestructive method of sample preparation and analysis is described for the infrared spectrophotometric analysis of synthetic fibers. This method uses a combined diamond cell and sapphire cell technique that yields highly resolved spectra with microgramsize fiber samples. From these highly resolved spectra, the generic type of fiber can be readily determined. Although the fiber sample has been physically crushed, it is not destroyed during the analysis and can be further examined by other analytical methods.

Succinic and Malic Oxidase in Gastric Hydrochloric Acid Production

1956 ◽  
Vol 187 (3) ◽  
pp. 427-431 ◽  
Author(s):  
Joseph J. Vitale ◽  
Oscar M. Jankelson ◽  
Patricia Connors ◽  
D. Mark Hegsted ◽  
Norman Zamcheck
Keyword(s):  
Gastric Mucosa ◽  
Guinea Pig ◽  
Succinic Dehydrogenase ◽  
Titratable Acidity ◽  
Spectrophotometric Analysis ◽  
Parietal Cells ◽  
Human Gastric Mucosa ◽  
City Hospital ◽  
Malic Dehydrogenase ◽  
Oxidase System

Effect of histamine on the activity of succinic oxidase and malic dehydrogenase was studied in guinea pig and human gastric mucosa. Human tissue was obtained through the surgical services of the Boston City Hospital. Control value for the succinic oxidase system of the proximal half of the guinea pig stomach was approximately 480 ( Qo2 (N) (µl O2/mg nitrogen/hr.)). After histamine, this value rose to 550 in 30 minutes with a simultaneous rise in titratable acidity of the stomach contents. Animals fasted for 72 hours had a Qo2 (N) of approximately 500 and after histamine a Qo2 (N) of 700 was observed. Spectrophotometric analysis of succinic dehydrogenase and cytochrome oxidase activities, two of the major components of the succinic oxidase system, revealed that both components are increased following histamine administration. Malic dehydrogenase, however, was not affected by histamine treatment. Succinic dehydrogenase was demonstrated by histochemical localization and was concentrated below the superficial mucous layer where parietal cells were abundant. Succinic oxidase activity of human gastric mucosa was demonstrable only in those specimens containing abundant parietal cells. This study confirms the view that HCl production by parietal cells is associated with aerobic metabolism and is perhaps under enzymatic control. The study suggests that the succinic oxidase system may be involved in the production or secretion of HCl.

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