Synthesis and Functionalization of Mesoporous Bioactive Glasses for Drug Delivery

2017 ◽  
pp. 257-286
Author(s):  
F. Branda
Keyword(s):  
Drug Delivery ◽  
Bioactive Glasses

Development of Novel Mesoporous Silica-Based Bioactive Glass Scaffolds with Drug Delivery Capabilities

2014 ◽  
Vol 96 ◽  
pp. 54-60 ◽  
Author(s):  
Anahí Philippart ◽  
Elena Boccardi ◽  
Lucia Pontiroli ◽  
Ana Maria Beltrán ◽  
Alexandra Inayat ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Simulated Body Fluid ◽  
Mesoporous Silica ◽  
Body Fluid ◽  
Glass Composition ◽  
Glass Structure ◽  
Sol Gel ◽  
Bioactive Glasses

Novel silica-based bioactive glasses were successfully prepared by the sol-gel method. The optimized glass composition for fabrication of the scaffolds was (in mol.%) 60% SiO2 – 30% CaO - 5% Na2O - 5% P2O5 (60S30C5N5P). This composition was confirmed to develop a thick hydroxycarbonate apatite (HCA) layer in Simulated Body Fluid (SBF) after 7 days, as revealed by Fourier Transform Infrared Spectroscopy (FTIR), indicating the bioactive character of the scaffolds. The mesoporous nature of the glass structure allows the load of tetracycline and a sustained release of the drug in PBS during 7 days was measured.

scholarly journals Mesoporous bioactive glasses as drug delivery and bone tissue regeneration platforms

2011 ◽  
Vol 2 (9) ◽  
pp. 1189-1198 ◽  
Author(s):  
Chengtie Wu ◽  
Jiang Chang ◽  
Yin Xiao
Keyword(s):  
Drug Delivery ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tissue Regeneration ◽  
Bioactive Glasses

Bio-inspired bioactive glasses for efficient microRNA and drug delivery

2017 ◽  
Vol 5 (31) ◽  
pp. 6376-6384 ◽  
Author(s):  
Xian Li ◽  
Qiming Liang ◽  
Wen Zhang ◽  
Yuli Li ◽  
Jiandong Ye ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Specific Surface ◽  
Porous Structure ◽  
Surface Area ◽  
Specific Surface Area ◽  
Large Specific Surface Area ◽  
Bioactive Glasses ◽  
Efficient Delivery

Inspired by nature's pinecone structure, we innovatively designed and synthesized pinecone-like bioactive glasses for the delivery of microRNAs and drugs. The particles showed a large specific surface area, unique porous structure, and efficient delivery of microRNAs and doxorubicin.

scholarly journals Mesoporous bioactive glasses: structure characteristics, drug/growth factor delivery and bone regeneration application

2012 ◽  
Vol 2 (3) ◽  
pp. 292-306 ◽  
Author(s):  
Chengtie Wu ◽  
Jiang Chang
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Growth Factor ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Growth Factor Delivery ◽  
Bioactive Glasses ◽  
The Past

The impact of bone diseases and trauma in the whole world has increased significantly in the past decades. Bioactive glasses are regarded as an important bone regeneration material owing to their generally excellent osteoconductivity and osteostimulativity. A new class of bioactive glass, referred to as mesoporous bioglass (MBG), was developed 7 years ago, which possess a highly ordered mesoporous channel structure and a highly specific surface area. The study of MBG for drug/growth factor delivery and bone tissue engineering has grown significantly in the past several years. In this article, we review the recent advances of MBG materials, including the preparation of different forms of MBG, composition–structure relationship, efficient drug/growth factor delivery and bone tissue engineering application. By summarizing our recent research, the interaction of MBG scaffolds with bone-forming cells, the effect of drug/growth factor delivery on proliferation and differentiation of tissue cells and the in vivo osteogenesis of MBG scaffolds are highlighted. The advantages and limitations of MBG for drug delivery and bone tissue engineering have been compared with microsize bioactive glasses and nanosize bioactive glasses. The future perspective of MBG is discussed for bone regeneration application by combining drug delivery with bone tissue engineering and investigating the in vivo osteogenesis mechanism in large animal models.

scholarly journals Polyelectrolyte-Coated Mesoporous Bioactive Glasses via Layer-by-Layer Deposition for Sustained Co-Delivery of Therapeutic Ions and Drugs

Pharmaceutics ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 1952
Author(s):  
Carlotta Pontremoli ◽  
Mattia Pagani ◽  
Lorenza Maddalena ◽  
Federico Carosio ◽  
Chiara Vitale-Brovarone ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Copper Ions ◽  
Release Kinetics ◽  
Delivery Systems ◽  
Burst Release ◽  
Incipient Wetness Impregnation ◽  
Layer By Layer ◽  
Bioactive Glasses ◽  
Polyelectrolyte Layer

In the field of bone regeneration, considerable attention has been addressed towards the use of mesoporous bioactive glasses (MBGs), as multifunctional therapeutic platforms for advanced medical devices. In fact, their extremely high exposed surface area and pore volume allow to load and the release of several drugs, while their framework can be enriched with specific therapeutic ions allowing to boost the tissue regeneration. However, due to the open and easily accessible mesopore structure of MBG, the release of the incorporated therapeutic molecules shows an initial burst effect leading to unsuitable release kinetics. Hence, a still open challenge in the design of drug delivery systems based on MBGs is the control of their release behavior. In this work, Layer-by-layer (LbL) deposition of polyelectrolyte multi-layers was exploited as a powerful and versatile technique for coating the surface of Cu-substituted MBG nanoparticles with innovative multifunctional drug delivery systems for co-releasing of therapeutic copper ions (exerting pro-angiogenic and anti-bacterial effects) and an anti-inflammatory drug (ibuprofen). Two different routes were investigated: in the first strategy, chitosan and alginate were assembled by forming the multi-layered surface, and, successively, ibuprofen was loaded by incipient wetness impregnation, while in the second approach, alginate was replaced by ibuprofen, introduced as polyelectrolyte layer. Zeta-potential, TGA and FT-IR spectroscopy were measured after the addition of each polyelectrolyte layer, confirming the occurrence of the stepwise deposition. In addition, the in vitro bioactivity and the ability to modulate the release of the cargo were evaluated. The polyelectrolyte coated-MBGs were proved to retain the peculiar ability to induce hydroxyapatite formation after 7 days of soaking in Simulated Body Fluid. Both copper ions and ibuprofen were co-released over time, showing a sustained release profile up to 14 days and 24 h, respectively, with a significantly lower burst release compared to the bare MBG particles.

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