scholarly journals Inflammation on the Mind: Visualizing Immunity in the Central Nervous System

Author(s):  
Silvia S. Kang ◽  
Dorian B. McGavern
1935 ◽  
Vol 81 (333) ◽  
pp. 317-331
Author(s):  
D. Noel Hardcastle

In considering the structure of the central nervous system as the vehicle for the mind, due regard must be paid to the vast amount of psychological knowledge which has been accumulated, and any new theories advanced must at least to some extent be able to explain accepted psychological material in neurological terms.


1961 ◽  
Vol 107 (451) ◽  
pp. 1043-1046
Author(s):  
David Bowsher

“O the mind, mind has mountains; cliffs of fall, Frightful, sheer, no-man-fathomed.”The importance of the anatomical basis of the simpler motor and sensory functions of the central nervous system, and their disorders, has been recognized for over a century (Brown-Séquard, 1855). But that more complex intellectual functions and their disorders should also have a relevant anatomical substrate is only slowly coming into recognition. Indeed, a still-fashionable theory of mental function, originating in Vienna towards the end of the last century, regards the study of brain structure as unnecessary and beneath contempt—for all that its founder began as a neuro-anatomist.


Entropy ◽  
2020 ◽  
Vol 22 (6) ◽  
pp. 611
Author(s):  
Robert E. Ulanowicz

Some dynamics associated with consciousness are shared by other complex macroscopic living systems. For example, autocatalysis, an active agency in ecosystems, imparts to them a centripetality, the ability to attract resources that identifies the system as an agency apart from its surroundings. It is likely that autocatalysis in the central nervous system likewise gives rise to the phenomenon of selfhood, id or ego. Similarly, a coherence domain, as constituted in terms of complex bi-level coordination in ecosystems, stands as an analogy to the simultaneous access the mind has to assorted information available over different channels. The result is the feeling that various features of one’s surroundings are present to the individual all at once. Research on these phenomena in other fields may suggest empirical approaches to the study of consciousness in humans and other higher animals.


2020 ◽  
pp. 5778-5780
Author(s):  
Adam Zeman

Medicine is traditionally regarded as concerning itself with disorders of the body while psychiatry concerns itself with disorders of the mind—and ‘never the twain shall meet’. But both everyday clinical experience and our growing understanding of the physical basis of mind challenge this view. Patients are always a compound of body and mind; discoveries relating to the mechanisms, phylogeny, ontogeny, and functions of the central nervous system are gradually traversing the mind-body and mind-brain divides. We should take a bio-psycho-social approach in every clinical encounter and seek theories that explain the emergence of mind from life much as life emerges from matter.


Author(s):  
Sisira Padavala ◽  
Ezhilarasan Devaraj

ABSTRACTCompounds in some plants have remarkable effects on the central nervous system. Plants containing those compounds are mind altering orpsychoactive in nature. These are consumed in the form of simple or complex preparations to affect the mind or alter the state of consciousness.Psychoactivity may include sedative, stimulant, euphoric, deliriant, and hallucinogenic effects. Several hundred psychoactive plants are known.Some important examples of psychoactive plants include Datura, Salvia, and Cannabis. Psychoactive plants have been used ritually, medicinally, andrecreationally for thousands of years. Hence, the sociocultural and economic significance of psychoactive plants is enormous.Keywords: Cannabis, Datura, Psychoactive plants, Euphoria, Hallucinogen.


Author(s):  
Gladys Harrison

With the advent of the space age and the need to determine the requirements for a space cabin atmosphere, oxygen effects came into increased importance, even though these effects have been the subject of continuous research for many years. In fact, Priestly initiated oxygen research when in 1775 he published his results of isolating oxygen and described the effects of breathing it on himself and two mice, the only creatures to have had the “privilege” of breathing this “pure air”.Early studies had demonstrated the central nervous system effects at pressures above one atmosphere. Light microscopy revealed extensive damage to the lungs at one atmosphere. These changes which included perivascular and peribronchial edema, focal hemorrhage, rupture of the alveolar septa, and widespread edema, resulted in death of the animal in less than one week. The severity of the symptoms differed between species and was age dependent, with young animals being more resistant.


Author(s):  
John L.Beggs ◽  
John D. Waggener ◽  
Wanda Miller ◽  
Jane Watkins

Studies using mesenteric and ear chamber preparations have shown that interendothelial junctions provide the route for neutrophil emigration during inflammation. The term emigration refers to the passage of white blood cells across the endothelium from the vascular lumen. Although the precise pathway of transendo- thelial emigration in the central nervous system (CNS) has not been resolved, the presence of different physiological and morphological (tight junctions) properties of CNS endothelium may dictate alternate emigration pathways.To study neutrophil emigration in the CNS, we induced meningitis in guinea pigs by intracisternal injection of E. coli bacteria.In this model, leptomeningeal inflammation is well developed by 3 hr. After 3 1/2 hr, animals were sacrificed by arterial perfusion with 3% phosphate buffered glutaraldehyde. Tissues from brain and spinal cord were post-fixed in 1% osmium tetroxide, dehydrated in alcohols and propylene oxide, and embedded in Epon. Thin serial sections were cut with diamond knives and examined in a Philips 300 electron microscope.


Author(s):  
Ezzatollah Keyhani

Acetylcholinesterase (EC 3.1.1.7) (ACHE) has been localized at cholinergic junctions both in the central nervous system and at the periphery and it functions in neurotransmission. ACHE was also found in other tissues without involvement in neurotransmission, but exhibiting the common property of transporting water and ions. This communication describes intracellular ACHE in mammalian bone marrow and its secretion into the extracellular medium.


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