The Centromere-Drive Hypothesis: A Simple Basis for Centromere Complexity

Author(s):  
Harmit S. Malik
2015 ◽  
Vol 2015 ◽  
pp. 1-13 ◽  
Author(s):  
Chaolong Jia ◽  
Lili Wei ◽  
Hanning Wang ◽  
Jiulin Yang

Wavelet is able to adapt to the requirements of time-frequency signal analysis automatically and can focus on any details of the signal and then decompose the function into the representation of a series of simple basis functions. It is of theoretical and practical significance. Therefore, this paper does subdivision on track irregularity time series based on the idea of wavelet decomposition-reconstruction and tries to find the best fitting forecast model of detail signal and approximate signal obtained through track irregularity time series wavelet decomposition, respectively. On this ideology, piecewise gray-ARMA recursive based on wavelet decomposition and reconstruction (PG-ARMARWDR) and piecewise ANN-ARMA recursive based on wavelet decomposition and reconstruction (PANN-ARMARWDR) models are proposed. Comparison and analysis of two models have shown that both these models can achieve higher accuracy.


PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e30496 ◽  
Author(s):  
František Zedek ◽  
Petr Bureš

1984 ◽  
Vol 29 (1) ◽  
pp. 132-136 ◽  
Author(s):  
Jason A. C. Gallas
Keyword(s):  

1984 ◽  
Vol 2 (2) ◽  
pp. 73-84
Author(s):  
Giorgio Stefani

Abstract The «fiscal crisis» cannot be solved on the simple basis of principles of economic rationality, without taking account of the institutional mechanisms. Politicians, bureaucrats, voters, do have a role in public decision-making and their behavior cannot be ignored.According to a generally shared view, local finance looks as an interesting field of research for Public Choice scientists since at local level the voter's ability to control the institutions is higher than at national level.This is true, however, only if we limit our attention to the relationship between local administrators and citizens. When the analysis includes the competition for funds among local governments, we have to deal with national problems, requiring the inclusion of variables whose behaviour is uneasy to predict.


2018 ◽  
Author(s):  
Takashi Akera ◽  
Emily Trimm ◽  
Michael A. Lampson

SummaryAsymmetric division in female meiosis creates selective pressure favoring selfish centromeres that bias their transmission to the egg. This centromere drive can explain the paradoxical rapid evolution of both centromere DNA and centromere-binding proteins despite conserved centromere function. Here, we define a molecular pathway linking expanded centromeres to histone phosphorylation and recrui™ent of microtubule destabilizing factors in an intraspecific hybrid, leading to detachment of selfish centromeres from spindle microtubules that would direct them to the polar body. We also introduce a second hybrid model, exploiting centromere divergence between species, and show that winning centromeres in one hybrid become losers in the other. Our results indicate that increasing destabilizing activity is a general strategy for drive, but centromeres have evolved distinct strategies to increase that activity. Furthermore, we show that drive depends on slowing meiotic progression, suggesting that a weakened meiotic spindle checkpoint evolved as a mechanism to suppress selfish centromeres.


1991 ◽  
Vol 15 (7) ◽  
pp. 446-449 ◽  
Author(s):  
Gavin Andrews

In 1987 there were 1,428 psychiatrists in Australia, 8.8 per 100,000 population (Burvill, 1988), 55% identified as in private practice and 45% in public sector practice. Let us be clear about terms. Public sector practice means that each week you receive a salary from the public purse whether you have seen one or a hundred patients. Private practice means that you are paid on a piece-work basis, also largely from the public purse (national health insurance or Medicare), but the income (at about $100 per hour) depends exactly on the number of hours spent with patients. On average, private psychiatrists in Australia gross about $150,000 per year, out of which they must pay practice expenses. The pay for public sector psychiatrists probably averages $70,000 to which, for the purposes of our calculation, we will add the cost of rooms, telephone and secretary provided by the hospital which at $30,000 brings the cost of a public sector psychiatrist to about $100,000 per year. If 45% of psychiatrists are in public practice then the averaged cost of a psychiatrist in Australia can be calculated as $127,500 per annum, and as there are 8.8 psychiatrists per 100,000 the cost, calculated on this simple basis, is $1.12 million per 100,000 population (Andrews, 1989).


1975 ◽  
Vol 30 (7-8) ◽  
pp. 535-537 ◽  
Author(s):  
A. H. Bretag ◽  
D. I. B. Kerr

Abstract Membrane channels formed by groups of subunits with a special form of interaction between the subunits provide a simple basis for models of membrane conductance. It is shown how the subunit interaction can explain conductance kinetics; particular attention being paid to characteristics of the potassium conductance in the squid piant axon.


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