scholarly journals A Software Tool for the Simulation and Optimization of Dynamic Metabolic Models

Author(s):  
Pedro Evangelista ◽  
Isabel Rocha ◽  
Eugénio C. Ferreira ◽  
Miguel Rocha
2021 ◽  
Vol 1 (1) ◽  
Author(s):  
Céline Vaneeckhaute ◽  
Eric Walling ◽  
Sonia Rivest ◽  
Evangelina Belia ◽  
Ian Chartrand ◽  
...  

AbstractBiomethanation projects across the world struggle with multiple challenges related to the location selection and optimization of the treatment facilities. Important aspects such as treatment plant location and treatment process chain configuration depend on the waste sources to be treated, the required end-product type and quality, as well as its final use destination, all of which are variable in time and space. This research describes the development and use of an integrated decision-support software tool that allows setting up optimal organic waste value chains, named optim-O. Key features of the tool include a multidimensional spatiotemporal database, a model-based decision module for simulation and optimization, as well as a user-friendly interface. The availability of such a software tool will not only allow to save time and money on data collection and calculations, but will also induce more comprehensive decisions by simultaneously taking into account a variety of factors, thereby significantly facilitating and enhancing the decision-making process.


Author(s):  
Kim Mennicken ◽  
Jörg Aign

Applications for dynamic simulation can be found in virtually all areas of process engineering. The tangible benefits of using dynamic simulation can be seen in tighter design, smoother start-ups and optimized operation. Thus, proper implementation of dynamic simulation can deliver substantial benefits. These benefits are typically derived from improved process understanding. Simulation gives confidence in evidence based decisions and enables users to try out lots of ‘what if’ scenarios until one is sure that a decision is the right one. In radioactive waste treatment tasks different kinds of waste with different volumes and properties have to be treated, e.g. from NPP operation or D&D activities. Finding a commercially and technically optimized waste treatment concept is a time consuming and difficult task. The Westinghouse Waste Simulation and Optimization Software Tool will enable the user to quickly generate reliable simulation models of various process applications based on equipment modules. These modules can be built with ease and be integrated into the simulation model. This capability ensures that this tool is applicable to typical waste treatment tasks. The identified waste streams and the selected treatment methods are the basis of the simulation and optimization software. After implementing suitable equipment data into the model, process requirements and waste treatment data are fed into the simulation to finally generate primary simulation results. A sensitivity analysis of automated optimization features of the software generates the lowest possible lifecycle cost for the simulated waste stream. In combination with proven waste management equipments and integrated waste management solutions, this tool provides reliable qualitative results that lead to an effective planning and minimizes the total project planning risk of any waste management activity. It is thus the ideal tool for designing a waste treatment facility in an optimum manner, taking account of the detailed waste stream and specific requirements.


Micromachines ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 1
Author(s):  
Rui Amendoeira Esteves ◽  
Chen Wang ◽  
Michael Kraft

The surge in fabrication techniques for micro- and nanodevices gave room to rapid growth in these technologies and a never-ending range of possible applications emerged. These new products significantly improve human life, however, the evolution in the design, simulation and optimization process of said products did not observe a similarly rapid growth. It became thus clear that the performance of micro- and nanodevices would benefit from significant improvements in this area. This work presents a novel methodology for electro-mechanical co-optimization of micro-electromechanical systems (MEMS) inertial sensors. The developed software tool comprises geometry design, finite element method (FEM) analysis, damping calculation, electronic domain simulation, and a genetic algorithm (GA) optimization process. It allows for a facilitated system-level MEMS design flow, in which electrical and mechanical domains communicate with each other to achieve an optimized system performance. To demonstrate the efficacy of the methodology, an open-loop capacitive MEMS accelerometer and an open-loop Coriolis vibratory MEMS gyroscope were simulated and optimized—these devices saw a sensitivity improvement of 193.77% and 420.9%, respectively, in comparison to their original state.


2010 ◽  
Vol 132 (2) ◽  
Author(s):  
Marco Danti ◽  
Davide Vigè ◽  
Guido Vincent Nierop

The cost and weight reduction requirements in automotive applications are very important targets in the design of a new car. For this reason, all the components of the vehicle have to be optimized and the design of the damping material layout has to be deeply analyzed in order to have a good noise, vibration, and harshness (NVH) performance with minimum mass and cost. A tool for the optimization of the damping material layout has been implemented and tested; the need to explore the entire design space with a big number of variables suggested the use of a genetic multi-objective algorithm for the optimization. These algorithms require a large number of calculations and the solution of the complete NVH model would be too expensive in terms of computation time. For this reason, a new software tool has been developed based on the simulation of the damping material treatments by means of an auxiliary mass and stiffness matrix, which was added to the baseline modal base; using this procedure, the required time for the simulation of each damping material layout configuration is reduced to a few minutes, allowing to exploit the genetic algorithm capability to efficiently explore the design space. As a result, some configurations with an important mass reduction or a much better acoustic performance have been found. This method has been verified on a simple Aluminum box in order to verify all the assumptions and to test the effectiveness in predicting the vibration levels of plates with free layer damping added to it.


2009 ◽  
Vol 16 (3) ◽  
pp. 287-299 ◽  
Author(s):  
Hossein Shokouhmand ◽  
Ali Mosahebi ◽  
Behrouz Karami Halashi

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