Belief Discernibility Matrix and Function for Incremental or Large Data

2013 ◽  
pp. 67-76
Author(s):  
Salsabil Trabelsi ◽  
Zied Elouedi ◽  
Pawan Lingras
Keyword(s):  
Large Data ◽  
Discernibility Matrix ◽  
And Function

Design and Realization of Roughness Measurement System Based on DM642

2009 ◽  
Vol 16-19 ◽  
pp. 1025-1029
Author(s):  
Yan Ling Zhao ◽  
Si Hai Cui ◽  
Liang Zhu ◽  
Feng Ling Wu
Keyword(s):  
Surface Roughness ◽  
Regression Analysis ◽  
Measurement System ◽  
Large Data ◽  
Roughness Measurement ◽  
Development Platform ◽  
Function Modules ◽  
Measurement Surface ◽  
And Function ◽  
The Relationship

For features of large data, complex operation and high transport in the process of measurement surface roughness, In this paper, roughness measurement system based on TMS320DM642 (DM642) as its core was designed, then established architecture of system and function modules is described in details, on this basis using of regression analysis to calibrate the relationship between image measuring roughness and actual values. Finally, this paper develops DSP software development platform.

scholarly journals Rockets, gauges, and pendulums: applying engineering principles to cell biology

2019 ◽  
Vol 30 (14) ◽  
pp. 1635-1640 ◽  
Author(s):  
William Sullivan
Keyword(s):  
Cell Biology ◽  
Large Data ◽  
Cell Cycle Checkpoints ◽  
Large Data Sets ◽  
Data Sets ◽  
Biological Clocks ◽  
New Techniques ◽  
Form And Function ◽  
Biological Form ◽  
And Function

From flight to radar to Velcro, biological form and function have inspired engineers for centuries. It is equally valuable to consider whether concepts in engineering might provide insights into core biological processes. To explore this idea, cell cycle checkpoints, biological clocks, and signaling pathways are viewed here from an engineering perspective. Engineering concepts covered include gauge error, the distinction between precision and accuracy, and the Taguchi method of robust design. Also discussed is the Pareto principle, which describes the observation that, in complex systems, a minority of the components (or inputs) are responsible for a majority of the outputs. These concepts enable engineers to manage complexity, both in system design and in operation. Thus, with new techniques and large data sets revealing ever-increasing levels of biological complexity, an engineering mindset may be particularly valuable for the study of living systems.

scholarly journals Voltage-Gated Calcium Channels in Nonexcitable Tissues

2020 ◽  
Vol 83 (1) ◽  
Author(s):  
Geoffrey S. Pitt ◽  
Maiko Matsui ◽  
Chike Cao
Keyword(s):  
Current Knowledge ◽  
Large Data ◽  
Cell Types ◽  
Annual Review ◽  
Publication Date ◽  
Membrane Excitability ◽  
Voltage Gated ◽  
Cellular Models ◽  
And Function ◽  
In Cells

The identification of a gain-of-function mutation in CACNA1C as the cause of Timothy syndrome, a rare disorder characterized by cardiac arrhythmias and syndactyly, highlighted roles for the L-type voltage-gated Ca2+ channel CaV1.2 in nonexcitable cells. Previous studies in cells and animal models had suggested that several voltage-gated Ca2+ channels (VGCCs) regulated critical signaling events in various cell types that are not expected to support action potential, but definitive data were lacking. VGCCs occupy a special position among ion channels, uniquely able to translate membrane excitability into the cytoplasmic Ca2+ changes that underlie the cellular responses to electrical activity. Yet how these channels function in cells not firing action potentials and what the consequences of their actions are in nonexcitable cells remain critical questions. The development of new animal and cellular models and the emergence of large data sets and unbiased genome screens have added to our understanding of the unanticipated roles for VGCCs in nonexcitable cells. Here, we review current knowledge of VGCC regulation and function in nonexcitable tissues and cells, with the goal of providing a platform for continued investigation. Expected final online publication date for the Annual Review of Physiology, Volume 83 is February 10, 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

Facilitating Autism Research

2017 ◽  
Vol 23 (9-10) ◽  
pp. 903-915 ◽  
Author(s):  
Deborah Fein ◽  
Molly Helt
Keyword(s):  
Environmental Influence ◽  
Large Data ◽  
Biological Data ◽  
Repetitive Behaviors ◽  
Large Data Sets ◽  
Social Impairment ◽  
Data Sets ◽  
Autism Research ◽  
Brain Structure And Function ◽  
And Function

AbstractEarly autism research focused on behavior and cognition. In recent decades, the pace of research has accelerated, and advances in imaging and genetics have allowed the accumulation of biological data. Nevertheless, a coherent picture of the syndrome at either phenotypic or biological level has not emerged. We see two fundamental obstacles to progress in basic understanding of autism. First, the two defining features (impairment in social interactions and communication, and restricted, repetitive behaviors and interests) are historically seen as integrally related. Others hold that these two major traits are fractionable and must be studied independently, casting doubt on autism as a coherent syndrome. Second, despite much recent research on brain structure and function, environmental factors, and genetics/genomics, findings on the biological level have not generally aligned well with those on the phenotypic level. In the first two sections, we explore these challenges, and in the third section, we review approaches that may facilitate progress, such as (1) including in studies all individuals defined by social impairment without regard to repetitive behaviors, (2) forming narrowly defined subtypes by thorough characterization on specific features, both diagnostic and non-diagnostic, (3) focusing on characteristics that may be relatively robust to environmental influence, (4) studying children as early as possible, minimizing environmental influence, and including longitudinal course as an important part of the phenotype, (5) subtyping by environmental risk factors, (6) distinguishing between what participants can do and what they typically do, and (7) aggregating large data sets across sites. (JINS, 2017, 23, 903–915)

Conformation of Ribosomes from Escherichia Coli

1974 ◽  
Vol 32 ◽  
pp. 210-211
Author(s):  
M. Boublik ◽  
W. Hellmann ◽  
F. Jenkins
Keyword(s):  
Binding Sites ◽  
Ribosomal Proteins ◽  
Fluorescent Dyes ◽  
Protein Biosynthesis ◽  
Three Dimensional ◽  
Spatial Arrangement ◽  
Dimensional Structure ◽  
Complete Understanding ◽  
And Function

The present knowledge of the three-dimensional structure of ribosomes is far too limited to enable a complete understanding of the various roles which ribosomes play in protein biosynthesis. The spatial arrangement of proteins and ribonuclec acids in ribosomes can be analysed in many ways. Determination of binding sites for individual proteins on ribonuclec acid and locations of the mutual positions of proteins on the ribosome using labeling with fluorescent dyes, cross-linking reagents, neutron-diffraction or antibodies against ribosomal proteins seem to be most successful approaches. Structure and function of ribosomes can be correlated be depleting the complete ribosomes of some proteins to the functionally inactive core and by subsequent partial reconstitution in order to regain active ribosomal particles.

The Effect of Oxidized Cholesterol on the Aorta of Rabbits- Scanning Electron Microscopic Observations

1982 ◽  
Vol 40 ◽  
pp. 340-341
Author(s):  
S. K. Pena ◽  
C. B. Taylor ◽  
J. Hill ◽  
J. Safarik
Keyword(s):  
Cholesterol Biosynthesis ◽  
Cholesterol Content ◽  
Arterial Injury ◽  
Electron Microscopic ◽  
Aortic Smooth Muscle ◽  
Oxidized Cholesterol ◽  
Initial Event ◽  
Membrane Structure And Function ◽  
Scanning Electron Microscopic ◽  
And Function

Introduction: Oxidized cholesterol derivatives have been demonstrated in various cell cultures to be very potent inhibitors of 3-hvdroxy-3- methylglutaryl Coenzyme A reductase which is a principle regulator of cholesterol biosynthesis in the cell. The cholesterol content in the cells exposed to oxidized cholesterol was found to be markedly decreased. In aortic smooth muscle cells, the potency of this effect was closely related to the cytotoxicity of each derivative. Furthermore, due to the similarity of their molecular structure to that of cholesterol, these oxidized cholesterol derivatives might insert themselves into the cell membrane, alter membrane structure and function and eventually cause cell death. Arterial injury has been shown to be the initial event of atherosclerosis.

Ultrastructure of developing visual cortical synapses in the cat superior colliculus

1991 ◽  
Vol 49 ◽  
pp. 156-157
Author(s):  
Caroline A. Miller ◽  
Laura L. Bruce
Keyword(s):  
Superior Colliculus ◽  
Phosphate Buffer ◽  
Receptive Fields ◽  
Visual Cortical Area ◽  
Cortical Synapses ◽  
Visual Cortical ◽  
And Function ◽  
Phosphate Buffered Saline ◽  
The Brain ◽  
Cat Superior Colliculus

The first visual cortical axons arrive in the cat superior colliculus by the time of birth. Adultlike receptive fields develop slowly over several weeks following birth. The developing cortical axons go through a sequence of changes before acquiring their adultlike morphology and function. To determine how these axons interact with neurons in the colliculus, cortico-collicular axons were labeled with biocytin (an anterograde neuronal tracer) and studied with electron microscopy.Deeply anesthetized animals received 200-500 nl injections of biocytin (Sigma; 5% in phosphate buffer) in the lateral suprasylvian visual cortical area. After a 24 hr survival time, the animals were deeply anesthetized and perfused with 0.9% phosphate buffered saline followed by fixation with a solution of 1.25% glutaraldehyde and 1.0% paraformaldehyde in 0.1M phosphate buffer. The brain was sectioned transversely on a vibratome at 50 μm. The tissue was processed immediately to visualize the biocytin.

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