The Normal Mucous Membrane and Inflammatory Changes

The aim of the study was to study and evaluate the predictive value of the immune microenvironment of gastric cancer and morphologically normal mucous membrane of the peritumoral area using an automatic morphometric analysis system on the example of CD 8+ cells.Material and Methods. Surgical samples from 130 patients with a verified diagnosis of gastric cancer were used. After immunohistochemical staining with antibodies to CD 8, a morphological assessment was performed according to the original method. We assessed the average area of CD 8+ cells in three fields of view (lens magn. ×20) using the automatic system of morphometric analysis LAS X (Leica) in the central part of the tumor and areas of morphologically normal mucous membrane of the peritumoral region directly adjacent to the tumor tissue. The results were compared with the main clinical and morphological characteristics of the tumor as well as with the overall five-year survival of patients.Results and Discussion. A high density of CD 8+ infiltration of normal mucous membrane of the peritumoral area was observed in groups T4a and T4b by the depth of invasion (n=96, p=0.0089) and was associated with the presence of emboli in the lymphatic vessels (n=96, p=0.0102) and with the more advanced stage of gastric cancer (n=96, p=0.0107). The studied cases were divided into two groups: less than 3300 square micrometers (better patient survival; n=79, p=0.01) and more than 3300 square micrometers according to the average area of CD 8+ cells in normal mucous membrane of the peritumoral area. According to multivariate survival analysis using the Cox regression model, it was found that the average area of CD 8+ cells in normal mucous membrane of the peritumoral area was a significant negative prognostic factor (RR=1.537; CI : 0.761–3.105; p<0.01) comparable in degree covariance with the stage of the tumor A similar indicator assessed in central part of the tumor was not significantly associated with patient survival (RR=0.803; CI : 0.574–1.122; p>0.05).Conclusion. The possibility of using an automatic analysis system to evaluate the immune microenvironment in gastric cancer was demonstrated for the first time. It was found that a high level of CD 8+ lymphocyte infiltration of morphologically normal mucous membrane of the peritumoral area was an independent negative prognostic factor. Therefore, we recommend the mandatory preoperative biopsy sampling from the mucous membrane of the peritumoral region for morphometric assessment of CD 8+ lymphocyte infiltration.

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Cases of noma

Kazan medical journal ◽

10.17816/kazmj52901 ◽

1938 ◽

Vol 34 (1) ◽

pp. 92-94

Author(s):

A. F. Rogov

Keyword(s):

Oral Cavity ◽

Mucous Membrane ◽

Traumatic Injury ◽

Older Age ◽

Independent Form ◽

Blood Clots ◽

Causative Agents ◽

Inflammatory Changes

Noma, water crayfish, was first described in 1816 (Baron). This severe suffering affects most children between the ages of 2 and 4. Cases of illness in older age are rare. The etiology of the disease is unknown. Chernyakhovsky considers it to be a maranth necrosis, and Krasin as an anemic necrosis. Oppel says that noma is a traumatic injury to the mucous membrane with the addition of infectious blood clots. Lexer argues that noma begins on the basis of inflammatory changes in the mucous membrane of the mouth. Schmidt finds no reason to isolate noma as an independent form of the disease and considers it to be a simple gangrene of the oral cavity. As the causative agents of the disease, diphtheria sticks, Vincent's sticks, streptotrix, leptotrix, cladotrix and symbiosis of spirochetes with a fusiform bacillus are called.

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Human Papillomavirus in Oral Leukoplakia, Verrucous Carcinoma, Squamous Cell Carcinoma, and Normal Mucous Membrane

Oman Medical Journal ◽

10.5001/omj.2015.89 ◽

2015 ◽

Vol 30 (6) ◽

pp. 455-460 ◽

Cited By ~ 3

Author(s):

Nasrollah Saghravanian ◽

Narges Ghazi ◽

Zahra Meshkat ◽

Nooshin Mohtasham

Keyword(s):

Squamous Cell Carcinoma ◽

Human Papillomavirus ◽

Cell Carcinoma ◽

Mucous Membrane ◽

Squamous Cell ◽

Verrucous Carcinoma ◽

Oral Leukoplakia ◽

Carcinoma Squamous Cell ◽

Normal Mucous Membrane

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An Investigation of the Pathology of “Grouse Disease.”

Journal of Hygiene ◽

10.1017/s0022172400033775 ◽

1910 ◽

Vol 10 (1) ◽

pp. 1-36 ◽

Cited By ~ 14

Author(s):

L. Cobbett ◽

G. S. Graham-Smith

Keyword(s):

Chronic Disease ◽

Mucous Membrane ◽

Causes Of Death ◽

Pathological Change ◽

Great Majority ◽

The Other ◽

Other Hand ◽

In Captivity ◽

Binocular Microscope ◽

Inflammatory Changes

The causes of death of the grouse are, of course, various. We ourselves have seen pleuropneumonia (in a bird long kept in captivity in Cambridge), pericarditis, necrotic patches in the liver, an obscure chronic disease of the peritoneum, and septic infection from a gangrenous fracture of the wing. On the other hand the great majority of birds, either picked up dead on the moor, or caught by keepers when weak and unable to fly, have been found to be all more or less in the same condition; they were wasted, badly infested with Trichostrongylus pergracilis, and often also with Davainea urogalli or Hymenolepis microps, or with both. More or less pathological change was seen in the caeca; the mucous membrane was often reddened, and under the binocular microscope considerable changes were seen, though we did not observe gross ulceration. Sections examined under the higher powers showed serious chronic inflammatory changes particularly in the immediate neighbourhood of the worms.

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Bilateral papillary ovarian cystoma and vaginal cyst

Journal of obstetrics and women s diseases ◽

10.17816/jowd12111407 ◽

1898 ◽

Vol 12 (11) ◽

pp. 1407

Author(s):

Editorial Board

Keyword(s):

Mucous Membrane ◽

Ovarian Cyst ◽

Vaginal Wall ◽

Ovarian Cysts ◽

Medical Review ◽

Normal Mucous Membrane ◽

The Right ◽

Cyst Cavity

Abstracts. Review of Obstetric and Gynecological literature: Russian.Sutkin. Bilateral papillary ovarian cyst and vaginal cyst- ("Medical Review", 1898, August).In a patient with papillary ovarian cysts and vaginal cysts, after removal of the ovarian cysts, the vaginal cyst, the size of a pigeon's egg, was also partially removed, so that the prominent segment of the tumor was captured by the dentate root and scissors of the free stump; a strip of sterilized gauze is inserted into the cyst cavity. When examining the vagina after 3 weeks, on the right side of it, correspondingly to the base of the former cyst, a barely imperceptible ridge is felt, going into the form of a longitudinal ellipsis; the very base of the cyst, which is now part of the vaginal wall, is, when examined, a normal mucous membrane.

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Fluorescence Bronchoscopy

Annals of Otology Rhinology & Laryngology ◽

10.1177/000348948209100113 ◽

1982 ◽

Vol 91 (1) ◽

pp. 57-60 ◽

Cited By ~ 1

Author(s):

Dietrich Hürzeler

Keyword(s):

Mucous Membrane ◽

False Negative ◽

Histological Change ◽

Ciliary Activity ◽

Negative Results ◽

False Negative Results ◽

Neoplastic Change ◽

Surface Marking ◽

Lymphangitis Carcinomatosa ◽

Normal Mucous Membrane

A new method of fluorescence bronchoscopy is presented which uses a standard light source and a special filter combination to permit the carrying out of fluorescence bronchoscopy with a surface marking method by means of inhaling a fluorescein solution. Normal mucous membrane, or mucous membrane with no histological change other than inflammation, which is cleansed by ciliary activity, does not usually fluoresce for a period longer than about two hours after the inhalation. There were, it is true, 13 false positive fluorescences out of 52 fluorescing areas in the mucous membrane. Correctly recorded were 39 cases of positive, ie, visible tumors, metaplasias, accumulation of mucous glands in the epithelium, and mucous membrane which had undergone a neoplastic change in the sense of a lymphangitis carcinomatosa or a mucous membrane carcinosis; these all caused fluorescence. The false negative results amounted to only two nonfluorescing tumors and one metaplasia. These diagnoses arise from the first 100 patients examined by this method. The fact must be especially emphasized that out of the 58 carcinoma cases, there were 7 where neoplastic changes in the mucous membrane were diagnosed by the fluorescence technique, although they had not been recognized macroscopically either by the naked eye or by the Hopkins optical technique.

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Prevention of inflammatory changes in the denture-bearing mucous membrane

Стоматология детского возраста и профилактика ◽

10.33925/1683-3031-2021-21-3-211-215 ◽

2021 ◽

Vol 21 (3) ◽

pp. 211-215

Author(s):

A. S. Peremyshlenko ◽

A. K. Iordanishvili ◽

P. A. Mushegyan ◽

A. G. Sirak ◽

A. A. Dolgalev

Keyword(s):

Mucous Membrane ◽

Oral Mucosa ◽

Functional Condition ◽

Main Group ◽

Control Group ◽

Adaptation Period ◽

Denture Adhesive ◽

Denture Stomatitis ◽

Edentulous Patients ◽

Inflammatory Changes

Relevance. Advanced clinical and cytological studies have not been conducted yet to examine denture adhesive effect on the prevention of inflammatory changes in the mucous membrane of the prosthetic bed, and thus, the prevention of denture-related stomatitis. Purpose: to assess the clinical and functional condition of the oral mucosa beneath the denture during the adaptation period using a denture adhesive cream to prevent inflammation of the denture bed mucous membrane.Materials and methods. The study clinically and cytologically (washing, scraping) assessed the condition of oral mucosa beneath complete acrylic dentures on days 14-16 and 28-30 of the adaptation period in 15 fully edentulous patients (main group), who used an adhesive cream after they were delivered their dentures, and in 21 fully edentulous patients (control group) who did not use the cream during the denture adaptation period. All the patients were elderly.Results. At different times of the adaptation period, the study more frequently detected inflammatory changes in the denture-bearing mucosa in subjects who did not use the denture adhesive cream. The cytological study confirmed the results of the oral clinical examination, as, at the end of the adaptation period, the number of cellular elements and various microorganisms was significantly lower in the main group than in the controls, which proved the effectiveness of the denture adhesive cream for the prevention of denture stomatitis.Conclusions. Regardless of sex, patients with complete acrylic dentures, who used a denture adhesive cream, had a lower bacterial accumulation on the prosthetic bed and inflammatory changes during the adaptation period, which allowed us to recommend the adhesive cream for the prevention of denture stomatitis.

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