Tumor-Associated Antigens and Immunity in Prostatic Carcinoma

1979 ◽  
pp. 65-80 ◽  
Author(s):  
R. J. Ablin ◽  
R. A. Bhatti ◽  
P. D. Guinan
Keyword(s):  
Prostatic Carcinoma ◽  
Tumor Associated Antigens

Prostatic Acid Phosphatase (PAP) Differentiated Ultracytochemically from Lysosomal Acid Phosphate in the Rat with a PAP/Specific Substrate, Phosphorylcholine

1975 ◽  
Vol 33 ◽  
pp. 450-451
Author(s):  
W. Allen Shannon ◽  
José A. Serrano ◽  
Hannah L. Wasserkrug ◽  
Anna A. Serrano ◽  
Arnold M. Seligman
Keyword(s):  
Acid Phosphatase ◽  
Phosphate Buffer ◽  
Prostatic Carcinoma ◽  
Prostatic Acid Phosphatase ◽  
Chemotherapeutic Agents ◽  
Specific Substrate ◽  
Acid Phosphate ◽  
Lysosomal Acid ◽  
Design And Synthesis ◽  
New Chemotherapeutic Agents

During the design and synthesis of new chemotherapeutic agents for prostatic carcinoma based on phosphorylated agents which might be enzyme-activated to cytotoxicity, phosphorylcholine, [(CH3)3+NCH2CH2OPO3Ca]Cl-, has been indicated to be a very specific substrate for prostatic acid phosphatase (PAP). This phenomenon has led to the development of specific histochemical and ultracytochemical methods for PAP using modifications of the Gomori lead method for acid phosphatase. Comparative histochemical results in prostate and kidney of the rat have been published earlier with phosphorylcholine (PC) and β-glycerophosphate (βGP). We now report the ultracytochemical results.Minced tissues were fixed in 3% glutaraldehyde-0.1 M phosphate buffered (pH 7.4) for 1.5 hr and rinsed overnight in several changes of 0.05 M phosphate buffer (pH 7.0) containing 7.5% sucrose. Tissues were incubated 30 min to 2 hr in Gomori acid phosphatase medium (2) containing 0.1 M substrate, either PC or βGP.

Tumor-Associated Antigens

JAMA ◽  
1973 ◽  
Vol 223 (2) ◽  
pp. 174 ◽  
Author(s):  
Stanley E. Order
Keyword(s):  
Tumor Associated Antigens

Neuroendocrine Differentiation in Prostatic Carcinoma

2003 ◽  
Vol 37 (0) ◽  
pp. 28-36 ◽  
Author(s):  
Jens Hansson ◽  
Per-Anders Abrahamsson
Keyword(s):  
Prostatic Carcinoma ◽  
Neuroendocrine Differentiation

Multiple Squamous Cell Carcinoma Associated with Prostatic Carcinoma

1976 ◽  
Vol 38 (6) ◽  
pp. 924-930 ◽  
Author(s):  
Hidekazu SHINODA ◽  
Kazuki MAEZIMA ◽  
Yasuko ISINO ◽  
Makoto HORI ◽  
Katsutaro NISHIMOTO
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Prostatic Carcinoma

scholarly journals Serum autoantibodies against a panel of 15 tumor-associated antigens in the detection of ovarian cancer

Tumor Biology ◽  
2017 ◽  
Vol 39 (6) ◽  
pp. 101042831769913 ◽  
Author(s):  
Hao Sun ◽  
Jian-Xiang Shi ◽  
Hong-Fei Zhang ◽  
Meng-Tao Xing ◽  
Pei Li ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Tumor Associated Antigens

Clinical value of tumor-associated antigens and autoantibody panel combination detection in the early diagnostic of lung cancer

2021 ◽  
pp. 1-9
Author(s):  
Renren Ouyang ◽  
Shiji Wu ◽  
Bo Zhang ◽  
Ting Wang ◽  
Botao Yin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lung Disease ◽  
Cytokeratin 19 ◽  
Healthy Controls ◽  
Control Groups ◽  
Clinical Value ◽  
Tumor Associated Antigens ◽  
Pathological Subtype ◽  
Positive Rate ◽  
Diagnosis Of Lung Cancer

BACKGROUND: This study aimed to investigate the efficiency of combining tumor-associated antigens (TAAs) and autoantibodies in the diagnosis of lung cancer. METHODS: The serum levels of TAAs and seven autoantibodies (7-AABs) were detected from patients with lung cancer, benign lung disease and healthy controls. The performance of a new panel by combing TAAs and 7-AABs was evaluated for the early diagnosis of lung cancer. RESULTS: The positive rate of 7-AABs was higher than the single detection of antibody. The positive rate of the combined detection of 7-AABs in lung cancer group (30.2%) was significantly higher than that of healthy controls (16.8%), but had no statistical difference compared with that of benign lung disease group (20.8%). The positive rate of 7-AABs showed a tendency to increase in lung cancer patients with higher tumor-node-metastasis (TNM) stages. For the pathological subtype analysis, the positive rate of 7-AABs was higher in patients with squamous cell carcinoma and small cell lung cancer than that of adenocarcinoma. The levels of carcinoembryonic antigen (CEA) and cytokeratin 19 fragment 211 (CYFRA 211) were significantly higher than that of benign lung disease and healthy control groups. An optimal model was established (including 7-AABs, CEA and CYFRA21-1) to distinguish lung cancer from control groups. The performance of this model was superior than that of single markers, with a sensitivity of 52.26% and specificity of 77.46% in the training group. Further assessment was studied in another validation group, with a sensitivity of 44.02% and specificity of 83%. CONCLUSIONS: The diagnostic performance was enhanced by combining 7-AABs, CEA and CYFRA21-1, which has critical value for the screening and early detection of lung cancer.

Steroid receptors and hormone responsiveness of human prostatic carcinoma

The Prostate ◽  
1982 ◽  
Vol 3 (5) ◽  
pp. 475-482 ◽  
Author(s):  
G. Concolino ◽  
A. Marocchi ◽  
G. Margiotta ◽  
C. Conti ◽  
F. Di Silverio ◽  
...  
Keyword(s):  
Prostatic Carcinoma ◽  
Steroid Receptors ◽  
Hormone Responsiveness
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