Kinetics of Measles Virus Antibodies in Multiple Sclerosis Patients in Correlation to the Clinical Course of the Disease

1980 ◽  
pp. 271-277
Author(s):  
P. G. Höher ◽  
E. K. Kuwert ◽  
S. Poser ◽  
H. J. Bauer
Keyword(s):  
Multiple Sclerosis ◽  
Measles Virus ◽  
Clinical Course ◽  
Measles Virus Antibodies ◽  
Multiple Sclerosis Patients ◽  
Kinetics Of

Clinical course in multiple sclerosis patients presenting with a history of progressive disease

2014 ◽  
Vol 3 (1) ◽  
pp. 67-71 ◽  
Author(s):  
K.S. Pandey ◽  
S.C. Krieger ◽  
C. Farrell ◽  
C. Hannigan ◽  
T. DeAngelis ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Progressive Disease ◽  
Clinical Course ◽  
History Of ◽  
Multiple Sclerosis Patients

Failure to Detect Measles Virus Rna, by Reverse Transcription-Polymerase Chain Reaction, in Peripheral Blood Leucocytes of Patients with Multiple Sclerosis

1996 ◽  
Vol 1 (4) ◽  
pp. 204-206 ◽  
Author(s):  
B. Brankin ◽  
M. Osman ◽  
L. Herlihy ◽  
S.A. Hawkins ◽  
S.L. Cosby
Keyword(s):  
Multiple Sclerosis ◽  
Polymerase Chain Reaction ◽  
Reverse Transcription ◽  
Peripheral Blood ◽  
Measles Virus ◽  
Chain Reaction ◽  
Specific Primers ◽  
Polymerase Chain ◽  
Multiple Sclerosis Patients ◽  
Peripheral Blood Leucocytes

We have examined peripheral blood leucocytes (PBLs) from 17 multiple sclerosis patients, two patients with rheumatoid arthritis, one case of acute childhood measles and one case of subacute sclerosing panencephalitis, as well as 19 healthy adult controls for measles virus (MV) RNA, by the technique of reverse transcription-polymerase chain reaction. MV nucleocapsid gene specific primers were used to amplify all PBL-derived cDNA samples. These proved to be negative with the exception of the sample derived from the acute measles case. Selected cases were examined further, using fusion gene and matrix gene specific primers. MV RNA could not be detected.

Intra-blood-brain barrier measles virus antibody synthesis in multiple sclerosis patients

Neurology ◽  
1983 ◽  
Vol 33 (1) ◽  
pp. 45-45 ◽  
Author(s):  
P. Albrecht ◽  
W. W. Tourtellotte ◽  
J. T. Hicks ◽  
H. Sato ◽  
E. J. Boone ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Blood Brain Barrier ◽  
Measles Virus ◽  
Brain Barrier ◽  
Virus Antibody ◽  
Antibody Synthesis ◽  
Blood Brain ◽  
Multiple Sclerosis Patients

scholarly journals Dynamics of quality of life indicators at a multiple sclerosis

2010 ◽  
Vol 9 (4) ◽  
pp. 63-69
Author(s):  
V. N. Karnaukh ◽  
Yu. A. Lugovtsova ◽  
I. A. Barabash
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Clinical Course ◽  
Life Quality ◽  
Immunomodulatory Therapy ◽  
Quality Factors ◽  
Quality Of Life Indicators ◽  
Sf 36 ◽  
Multiple Sclerosis Patients

The study explored the life quality of 94 multiple sclerosis patients in comparison to healthy respondents and in dependence to different parameters of the disease with the use of SF-36 questionnaire. The study has discovered a decline of all the factors of life quality and their dependence on disablement intensity, clinical course and duration of the disease. Immunomodulatory therapy contributed to the improvement of life quality factors.

scholarly journals Polymorphisms in the CIITA −168A/G (rs3087456) and CIITA +1614G/C (rs4774) may influence severity in multiple sclerosis patients

2019 ◽  
Vol 77 (3) ◽  
pp. 166-173 ◽  
Author(s):  
Valéria Coelho Santa Rita Pereira ◽  
Fabrícia Lima Fontes-Dantas ◽  
Eduardo Ribeiro Paradela ◽  
Fabíola Rachid Malfetano ◽  
Simone de Souza Batista Scherpenhuijzen ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Course ◽  
Nucleotide Polymorphisms ◽  
Expanded Disability Status Scale ◽  
Disability Progression ◽  
Single Nucleotide ◽  
Disability Status ◽  
Multiple Sclerosis Patients ◽  
The Impact ◽  
Lower Odds Ratio

ABSTRACT It is currently unknown how genetic factors may influence the clinical course of multiple sclerosis (MS). Objective: We examined the impact of CIITA polymorphisms −168A/G (rs3087456) and +1614G/C (rs4774) on the risk of disability progression, severity and on responses to first-line immunomodulator treatments. Methods: Genomic DNA was extracted from blood samples. We used ABI3730xl and GeneMapper v.4.0 software to identify genotype variations. All patients were followed up and clinically reassessed at three-month intervals. Disability progression was measured by the Expanded Disability Status Scale and disease severity by the Multiple Sclerosis Spasticity Scale (MSSS). Results: We included 37 men and 80 women. We found no evidence regarding the influence of the single nucleotide polymorphisms studied in the Expanded Disability Status Scale or therapeutic response of the evaluated drugs. We performed a logistic regression analysis with the MSSS and found that a less severe MS course was associated with wild type CIITA −168AA and CIITA +1614GG, as the chance of the patient progressing to MSSS2 and MSSS3 decreased in 61% and 75% with CIITA −168AA and 66% and 75% with CIITA +1614GG, respectively (p < 0.0001). Although less significant, the CIITA +1614 GC also pointed to a less severe MS course and the chance of the patient progressing to MSSS3 decreased 79% (p = 0.015). We also observed that the CIITA −168GG genotype was more frequent in MSSS2 and MSSS3 and had 40% lower odds ratio to becoming more severe MS. Conclusion: These data suggest that CIITA −168AA, CIITA +1614GG and CIITA +1614 GC polymorphisms may be associated with a better MS clinical course. This knowledge may be useful for a better understanding of MS and its therapeutic management.

scholarly journals Antiviral immune response in patients with multiple sclerosis and healthy siblings

2010 ◽  
Vol 16 (3) ◽  
pp. 355-358 ◽  
Author(s):  
M. Comabella ◽  
X. Montalban ◽  
A. Horga ◽  
B. Messmer ◽  
K. Kakalacheva ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Measles Virus ◽  
Epstein Barr Virus ◽  
Virus Antigen ◽  
Nuclear Antigen ◽  
Antiviral Immune Response ◽  
Barr Virus ◽  
Healthy Siblings ◽  
Epstein Barr ◽  
Multiple Sclerosis Patients

The objective of this study was to determine the immune responses to candidate viral triggers of multiple sclerosis in patients and healthy siblings raised in the same family household. Virus antigen-specific IgG responses to Epstein—Barr virus-derived gene products as well as to human herpersvirus-6, human cytomegalovirus, and measles virus were evaluated in 25 multiple sclerosis patients and compared with 49 healthy full-siblings. IgG responses to the latent Epstein—Barr virus-encoded nuclear antigen-1 (EBNA1) were selectively increased in individuals with multiple sclerosis compared with their unaffected siblings. We conclude that elevated IgG responses towards EBNA1 are associated with the development of multiple sclerosis.

scholarly journals Adhesion molecules and proinflammatory cytokines in cerebrospinal fluid of multiple sclerosis patients

2009 ◽  
Vol 8 (1(2)) ◽  
pp. 23-26
Author(s):  
S. A. Yelchaninova ◽  
I. V. Smagina ◽  
V. A. Sidorenko ◽  
Yu. N. Lichenko ◽  
A. V. Popovtseva ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Tumor Necrosis ◽  
Clinical Course ◽  
Cerebral Tissue ◽  
Tnf Α ◽  
Multiple Sclerosis Patients ◽  
Necrosis Factor

In liquor 30 multiple sclerosis patients with remittent kind of clinical course the concentration of cell-cell adhesion molecules (sPECAM-1, sVCAM-1) and tumor necrosis factor (TNF) α, not interleukin-1β, was higher during the period of exacerbation compared to the period of remission. These changes are supposed to display the activity of pathogenesis important processes multiple sclerosis in cerebral tissue of multiple sclerosis patients.

Pregnancy in multiple sclerosis patients treated with immunomodulators prior to or during part of the pregnancy: a descriptive study in the Spanish population

2007 ◽  
Vol 13 (8) ◽  
pp. 981-984 ◽  
Author(s):  
V. De las Heras ◽  
C. De Andrés ◽  
N. Téllez ◽  
M. Tintoré ◽  
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Practice ◽  
Relapse Rate ◽  
Pregnancy Outcomes ◽  
Medical Records ◽  
Clinical Course ◽  
Post Partum ◽  
Accidental Exposure ◽  
Multicentric Study ◽  
Multiple Sclerosis Patients

Objectives To study the management of pregnancy in multiple sclerosis (MS) patients on immunomodulatory therapy (IMT) in routine clinical practice and to analyze pregnancy outcomes and the clinical course of MS around pregnancy. Methods Retrospective, multicentric study in Spain in MS patients receiving IMT before conception and followed for at least three months post-partum. Results A total of 1286 medical records were reviewed. Eighty-eight pregnancies were identified in 74 (6%) women, 66% of which were unexposed and 34% exposed pregnancies. In most cases, IMT was discontinued before conception and resumed shortly after delivery. Accidental exposure to IMT did not lead to higher rates of abortions ( P = 0.76) or malformations. The relapse rate was decreased during pregnancy (0.31 versus 0.61 in the pre-pregnancy year) and increased after delivery (0.87 on month 3), returning to pre-conception values on month 12. The median EDSS score was not increased during the study. Conclusions Discontinuation of IMT before conception, and resumption shortly after delivery was the most frequent clinical practice procedure. Accidental exposure to IMT did not affect pregnancy outcomes or increased malformation rates. Pregnancy was associated with a reduced relapse rate. No factor was found to predict the risk of relapses during or after pregnancy. Multiple Sclerosis 2007; 13: 981—984. http://msj.sagepub.com

Sign in / Sign up

Export Citation Format

Share Document