Intracranial Pressure Time Course in Massive Ischemic Brain Infarction

1980 ◽  
pp. 352-355
Author(s):  
I. Papo ◽  
G. Caruselli ◽  
M. Scarpelli ◽  
A. Luongo
Keyword(s):  
Intracranial Pressure ◽  
Time Course ◽  
Brain Infarction ◽  
Ischemic Brain ◽  
Pressure Time ◽  
Ischemic Brain Infarction

Intracranial Pressure Time Course in Primary Intracerebral Hemorrhage

Neurosurgery ◽  
1979 ◽  
Vol 4 (6) ◽  
pp. 504-511 ◽  
Author(s):  
Isacco Papo ◽  
Pierre Janny ◽  
Giuseppe Caruselli ◽  
Gilles Colnet ◽  
Antonio Luongo
Keyword(s):  
Intracranial Pressure ◽  
Time Course ◽  
Elevated Pressure ◽  
Deep Coma ◽  
Postoperative Course ◽  
Disturbance Of Consciousness ◽  
Pressure Time ◽  
Intermediate Disturbances ◽  
Over Time ◽  
Definite Correlation

abstract The course of intracranial pressure (ICP) over time was studied in 66 hypertensive and/or atherosclerotic patients harboring intracerebral hematomas. Patients with no disturbance of consciousness showed normal or only slightly elevated pressure. Conversely, most patients in deep coma exhibited high pressure with a tendency to rise further no matter what treatment was used. In the remaining patients with intermediate disturbances of consciousness, no definite correlation was found between ICP, clinical condition, and outcome. In all of the patients who underwent operation, the postoperative course of ICP over time was also studied and seemed to depend to a certain extent on the timing of the operation.

scholarly journals Inhibition of Neutrophil Migration by a Protein Kinase Inhibitor for the Treatment of Ischemic Brain Infarction

1999 ◽  
Vol 80 (1) ◽  
pp. 41-48 ◽  
Author(s):  
Satoh Shin-ichi ◽  
Kobayashi Teruki ◽  
Hitomi Asako ◽  
Ikegaki Ichiro ◽  
Suzuki Yoshio ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Kinase Inhibitor ◽  
Brain Infarction ◽  
Neutrophil Migration ◽  
Protein Kinase Inhibitor ◽  
Ischemic Brain ◽  
Ischemic Brain Infarction

Serum cortisol and outcome of ischemic brain infarction

1993 ◽  
Vol 116 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Kari Murros ◽  
Rainer Fogelholm ◽  
Sanna Kettunen ◽  
Arja-Liisa Vuorela
Keyword(s):  
Brain Infarction ◽  
Serum Cortisol ◽  
Ischemic Brain ◽  
Ischemic Brain Infarction

scholarly journals Assessment of Brain Lesions in Type 2 Diabetes Mellitus and Hypertension using Magnetic Resonance imaging

2020 ◽  
Vol 10 (4) ◽  
pp. 382-386
Author(s):  
Qurain Alshammari ◽  
Mohammed Salih ◽  
Moawia Gameraddin ◽  
Bushra Abdelmalik ◽  
Sultan Alshoabi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Brain Infarction ◽  
Brain Lesions ◽  
Resonance Imaging ◽  
Ischemic Brain ◽  
Ischemic Brain Infarction

Background: Type 2 diabetes mellitus (T2DM) and hypertension (HTN) are risk factors for the spectrum of brain lesions. In this paper, we studied the impact of T2DM and HTN on the incidence of several brain lesions diagnosed with magnetic resonance imaging (MRI). Methods and Results: This retrospective, single-center study was conducted at Royal Care International Hospital (Khartoum, Sudan) from January 2016 to December 2016 and included 80 patients (40 male and 40 female, aged between 20 years and 90 years) with suspected brain disorders. MRI brain examinations were conducted on a 1.5 Tesla MRI system (Toshiba Medical Systems, Tokyo, Japan). The following sequences were analyzed: T1-weighted imaging (T1WI), T2-weighted imaging (T2WI), fluid-attenuated inversion recovery (FLAIR), and diffusion-weighted imaging (DWI). Brain lesions were characterized by magnetic imaging spectroscopy and histopathological analysis. Binary logistic regression analysis was used to establish a mathematical model of the relationship between T2DM/HTN and the prevalence of brain lesions. Among 80 patients, HTN, T2D, and the combination of T2D and HTN were identified in 18(22.5%), 9(11.2%), and 11(13.8%) patients, respectively. Brain lesions were found in 48(60%) patients and were most prevalent in the age group of 66-80 years. The brain lesions included ischemic brain infarction (IBI) (22.5%), brain tumors (11.2%), cerebral hemorrhages (6.2%), brain atrophy (BA) (1.2 %), IBI with BA (16.2%), and brain metastases (2.5%). Regression analysis showed that HTN and T2DM were associated with significantly higher ORs for brain lesions ([OR=2.459, 95% CI: 1.673–3.614, P<0.001] and [OR=1.507, 95% CI: 1.067–2.128, P= 0.042], and [OR=1.078, 95% CI:1.033–1.124, P=0.001], respectively). HTN was associated with significantly higher OR for ischemic brain infarction (OR=7.404, 95% CI: 2.600–21.081, P<0.001). Conclusion: The study showed a significant interaction between HTN and T2DM on the prevalence of brain lesions, especially ischemic brain infarction and brain atrophy.

scholarly journals Nationwide survey of ischemic brain infarction in Japan.

Nosotchu ◽  
2000 ◽  
Vol 22 (4) ◽  
pp. 628-633
Author(s):  
Takenori Yamaguchi ◽  
Kazumi Kimura ◽  
Kazuo Hashi ◽  
Isamu Saito ◽  
Takashi Owada ◽  
...  
Keyword(s):  
Brain Infarction ◽  
Nationwide Survey ◽  
Ischemic Brain ◽  
Ischemic Brain Infarction

scholarly journals Ischemic Brain Infarction

CNS Spectrums ◽  
2000 ◽  
Vol 5 (3) ◽  
pp. 21-21
Author(s):  
Deborah R. Horowitz
Keyword(s):  
Brain Infarction ◽  
Ischemic Brain ◽  
Ischemic Brain Infarction

Relation of hyperglycemia early in ischemic brain infarction to cerebral anatomy, metabolism, and clinical outcome

1990 ◽  
Vol 28 (2) ◽  
pp. 129-135 ◽  
Author(s):  
Michael Kushner ◽  
Patrizia Nencini ◽  
Martin Reivich ◽  
Mario Rango ◽  
Dara Jamieson ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Brain Infarction ◽  
Ischemic Brain ◽  
Ischemic Brain Infarction

Blood glucose, glycosylated haemoglobin, and outcome of ischemic brain infarction

1992 ◽  
Vol 111 (1) ◽  
pp. 59-64 ◽  
Author(s):  
Kari Murros ◽  
Rainer Fogelholm ◽  
Sanna Kettunen ◽  
Arja-Liisa Vuorela ◽  
Juha Valve
Keyword(s):  
Blood Glucose ◽  
Brain Infarction ◽  
Glycosylated Haemoglobin ◽  
Ischemic Brain ◽  
Ischemic Brain Infarction

scholarly journals Silencing the lncRNA Maclpil in pro-inflammatory macrophages attenuates acute experimental ischemic stroke via LCP1 in mice

2019 ◽  
Vol 40 (4) ◽  
pp. 747-759 ◽  
Author(s):  
Yan Wang ◽  
Ying Luo ◽  
Yang Yao ◽  
Yuhua Ji ◽  
Liangshu Feng ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ischemic Stroke ◽  
Expression Profiles ◽  
Brain Infarction ◽  
Cell Types ◽  
Specific Cell ◽  
Ischemic Brain ◽  
Inflammatory Gene Expression ◽  
Inflammatory Gene ◽  
Ischemic Brain Infarction

Long noncoding RNAs (lncRNA) expression profiles change in the ischemic brain after stroke, but their roles in specific cell types after stroke have not been studied. We tested the hypothesis that lncRNA modulates brain injury by altering macrophage functions. Using RNA deep sequencing, we identified 73 lncRNAs that were differentially expressed in monocyte-derived macrophages (MoDMs) and microglia-derived macrophages (MiDMs) isolated in the ischemic brain three days after stroke. Among these, the lncRNA, GM15628, is highly expressed in pro-inflammatory MoDMs but not in MiDMs, and are functionally related to its neighbor gene, lymphocyte cytosolic protein 1 (LCP1), which plays a role in maintaining cell shape and cell migration. We termed this lncRNA as Macrophage contained LCP1 related pro-inflammatory lncRNA, Maclpil. Using cultured macrophages polarized by LPS, M(LPS), we found that downregulation of Maclpil in M(LPS) decreased pro-inflammatory gene expression while promoting anti-inflammatory gene expression. Maclpil inhibition also reduced the migration and phagocytosis ability of MoDMs by inhibiting LCP1. Furthermore, adoptive transfer of Maclpil silenced M(LPS), reduced ischemic brain infarction, improved behavioral performance and attenuated penetration of MoDMs in the ischemic hemisphere. We conclude that by blocking macrophage, Maclpil protects against acute ischemic stroke by inhibiting neuroinflammation.

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