The Influence of Baboon Liver Hemoperfusion on Serum Levels of Amino Acids and Free Fatty Acids in Patients with Acute Liver Failure

1981 ◽  
pp. 293-300
Author(s):  
Karl-Josef Gundermann ◽  
Klaus Olek ◽  
Siegfried Uhlhaas ◽  
Tschong Su Lie
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Free Fatty Acids ◽  
Serum Levels

1010-P: Effects of MEDI0382, an Oxyntomodulin-Like Peptide with Targeted GLP-1/Glucagon Receptor Activity, on Amino Acids, Ketones, and Free Fatty Acids

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1010-P
Author(s):  
VICTORIA E. PARKER ◽  
DARREN ROBERTSON ◽  
TAO WANG ◽  
DAVID C. HORNIGOLD ◽  
MAXIMILIAN G. POSCH ◽  
...  
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Receptor Activity ◽  
Glucagon Receptor

Decreased serum levels of free fatty acids are associated with breast cancer

2014 ◽  
Vol 437 ◽  
pp. 31-37 ◽  
Author(s):  
Yaping Zhang ◽  
Lina Song ◽  
Ning Liu ◽  
Chengyan He ◽  
Zhili Li
Keyword(s):  
Breast Cancer ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Serum Levels

Hydrocarbons, free fatty acids, and amino acids of sclerotia of Sclerotinia sclerotiorum

1970 ◽  
Vol 75 (1) ◽  
pp. 59-66 ◽  
Author(s):  
John D. Weete ◽  
D. J. Weber ◽  
Duane Tourneau
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
Free Fatty Acids ◽  
Sclerotinia Sclerotiorum

scholarly journals Altitudinal Variation of Metabolites, Mineral Elements and Antioxidant Activities of Rhodiola crenulata (Hook.f. & Thomson) H.Ohba

Molecules ◽  
2021 ◽  
Vol 26 (23) ◽  
pp. 7383
Author(s):  
Tingting Dong ◽  
Yueqi Sha ◽  
Hairong Liu ◽  
Liwei Sun
Keyword(s):  
Amino Acids ◽  
Fatty Acids ◽  
Ascorbic Acid ◽  
Free Fatty Acids ◽  
High Altitude ◽  
Antioxidant Activities ◽  
Shikimic Acid ◽  
Ascorbic Acid Content ◽  
Phenolic Components ◽  
Rhodiola Crenulata

Rhodiolacrenulata (Hook.f. & Thomson) H.Ohba is an alpine medicinal plant that can survive in extreme high altitude environments. However, its changes to extreme high altitude are not yet clear. In this study, the response of Rhodiola crenulata to differences in altitude gradients was investigated through chemical, ICP-MS and metabolomic methods. A targeted study of Rhodiola crenulata growing at three vertical altitudes revealed that the contents of seven elements Ca, Sr, B, Mn, Ni, Cu, and Cd, the phenolic components, the ascorbic acid, the ascorbic acid/dehydroascorbate ratio, and the antioxidant capacity were positively correlated with altitude, while the opposite was true for total ascorbic acid content. Furthermore, 1165 metabolites were identified: flavonoids (200), gallic acids (30), phenylpropanoids (237), amino acids (100), free fatty acids and glycerides (56), nucleotides (60), as well as other metabolites (482). The differential metabolite and biomarker analyses suggested that, with an increasing altitude: (1) the shikimic acid-phenylalanine-phenylpropanoids-flavonoids pathway was enhanced, with phenylpropanoids upregulating biomarkers much more than flavonoids; phenylpropanes and phenylmethanes upregulated, and phenylethanes downregulated; the upregulation of quercetin was especially significant in flavonoids; upregulation of condensed tannins and downregulation of hydrolyzed tannins; upregulation of shikimic acids and amino acids including phenylalanine. (2) significant upregulation of free fatty acids and downregulation of glycerides; and (3) upregulation of adenosine phosphates. Our findings provide new insights on the responses of Rhodiola crenulata to extreme high altitude adversity.

scholarly journals Vitamin D-Binding Protein (Gc-Globulin) in Acute Liver Failure in Children

Diagnostics ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 278
Author(s):  
Alina Grama ◽  
Lucia Burac ◽  
Cornel Olimpiu Aldea ◽  
Bogdan Bulata ◽  
Dan Delean ◽  
...  
Keyword(s):  
Vitamin D ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Binding Protein ◽  
Area Under The Curve ◽  
Serum Levels ◽  
Control Group ◽  
Vitamin D Binding Protein ◽  
Disease Outcomes ◽  
Poor Outcomes

This study aimed to analyse vitamin D-binding protein (Gc-globulin) serum levels in acute liver failure (ALF) in children in relation to disease outcomes and correlations with other known markers used to evaluate the severity of ALF. Our study included 34 children (mean age 4.87 ± 5.30 years) with ALF of different causes (metabolic, 26.47%; autoimmune, 23.53%; toxic, 20.59%; infection, 17.65%; unknown, 11.76%) and 30 children without any liver injury (mean age 6.11 ± 4.26 years). The outcome was poor in 14 patients (41.18%), including one child with liver transplantation (2.94%). Serum Gc-globulin levels were significantly lower in ALF patients compared to the control group (151.57 ± 171.8 mg/L vs. 498.63 ± 252.50 mg/L; p < 0.000001), with an optimum cut-off of 163.5 mg/L (Area Under the Curve, AUC, 0.8921; sensitivity, 76.50%; specificity, 100%). Levels were also lower in patients with poor outcomes compared to survivors (59.34 ± 33.73 mg/L vs. 216.12 ± 199.69 mg/L; p < 0.0001), with an optimum cut-off 115 mg/L (AUC, 0.7642; sensitivity, 100%; specificity, 50%). Gc-globulin serum levels were variable according to ALF aetiology, i.e., lower in metabolic, infectious, or unknown causes compared to autoimmune and toxic causes. Gc-globulin serum levels were decreased in children with ALF and lower in those with poor outcomes compared with survivors. Gc-globulin serum levels were correlated with other known parameters used to evaluate the severity of ALF and could help to identify patients at high risk for poor outcomes.

scholarly journals Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure

2020 ◽  
Vol 11 (2) ◽  
Author(s):  
Naoya Yamada ◽  
Tadayoshi Karasawa ◽  
Hiroaki Kimura ◽  
Sachiko Watanabe ◽  
Takanori Komada ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Liver Failure ◽  
Acute Liver Failure ◽  
Radical Oxidation
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