FUTURE TECHNOLOGY – Development of ologic™ technology for enhanced adoptability

Author(s):  
Isao Kuwayama
2021 ◽  
Author(s):  
Xuechun Feng ◽  
Víctor López Del Amo ◽  
Enzo Mameli ◽  
Megan Lee ◽  
Alena L. Bishop ◽  
...  

ABSTRACTCulex mosquitoes are a global vector for multiple human and animal diseases, including West Nile virus, lymphatic filariasis, and avian malaria, posing a constant threat to public health, livestock, companion animals, and endangered birds. While rising insecticide resistance has threatened the control of Culex mosquitoes, advances in CRISPR genome-editing tools have fostered the development of alternative genetic strategies such as gene drive systems to fight disease vectors. However, though gene-drive technology has quickly progressed in other mosquitoes, advances have been lacking in Culex. Here, we developed a Culex-specific Cas9/gRNA expression toolkit and used site-directed homology-based transgenesis to generate and validate a Culex quinquefasciatus Cas9-expressing line. We showed that gRNA scaffold variants improve transgenesis efficiency in both Culex and Drosophila and boost gene-drive performance in the fruit fly. These findings support future technology development to control Culex mosquitoes and provide valuable insight for improving these tools in other species.


1992 ◽  
Vol 38 (7) ◽  
pp. 1280-1281
Author(s):  
P Wilding

Abstract In this paper I examine some of the factors influencing technology development and attempt to explain whether CLIA '88 enhances the opportunities or exacerbates the problems for U.S.-based technology development. The viewpoint I express is concentrated on the clinical chemistry segment of the diagnostics arena.


2013 ◽  
Vol 748 ◽  
pp. 490-492 ◽  
Author(s):  
Ke Chao ◽  
Jing Liu

This paper through patent map fuzzy cluster analysis system and method, researches development status in the fields of wind power, and the patent technology focus areas and its own characteristics , putting an emphasis analysis on patent technology of wind power around the world , we summarize and generalize technology development trends , and the future technology identified methods of the patents focus areas are discussed. Finally, we put forward a idea which comes from technology identification to prediction and evaluation.


2006 ◽  
Vol 110 (1106) ◽  
pp. 257-263 ◽  
Author(s):  
M. R. Mendenhall

Abstract The recent decline in the USA aerospace industry has resulted in fewer programs, fewer engineers, and a potential loss of capability for future technology development. As engineers retire or leave the industry, their corporate memory or retained knowledge must be preserved for future use. A process to capture their expert knowledge is described, and a framework which provides a means to retrieve and use this valuable technical information is shown. Four examples of integrated design and analysis systems for four diverse technologies and applications are discussed.


foresight ◽  
2014 ◽  
Vol 16 (3) ◽  
pp. 198-209 ◽  
Author(s):  
Moonjung Choi ◽  
Han-Lim Choi ◽  
Heyoung Yang

Purpose – The aim of this paper is to describe procedural characteristics of the 4th technology foresight (TF) using search engines to discover emerging issues; analytic framework development to discover future needs; future technologies considering future needs as well as technology development; detailed description of future technology; analytical discussions of Delphi survey results; developing spatial-specific scenarios and illustrations; and examining possible adverse effects of future technologies. Korea performs TF every 5 years to establish science and technology policy and strategies. In the 4th TF, future technologies that might be developed by 2035 were discovered and Delphi survey was conducted to examine current development status, anticipated times of technology development and public use, plans to secure these technologies, etc. Design/methodology/approach – This paper divides procedure employed in the 4th TF into three steps and explains seven characteristics related to its procedure. Findings – Improvement of the TF procedure will increase the reliability and applicability of its results. Originality/value – This paper consists of original results which include improved procedure and its implication by researchers who participated in the 4th TF. It will provide a useful example for other nations, hoping to introduce TF to set up national science and technology policy.


Instruments ◽  
2019 ◽  
Vol 3 (4) ◽  
pp. 62 ◽  
Author(s):  
Xiaorong Wang ◽  
Stephen A. Gourlay ◽  
Soren O. Prestemon

To enable the physics research that continues to deepen our understanding of the Universe, future circular colliders will require a critical and unique instrument—magnets that can generate a dipole field of 20 T and above. However, today’s maturing magnet technology for low-temperature superconductors (Nb-Ti and Nb 3 Sn) can lead to a maximum dipole field of around 16 T. High-temperature superconductors such as REBCO can, in principle, generate higher dipole fields but significant challenges exist for both conductor and magnet technology. To address these challenges, several critical research needs, including direct needs on instrumentation and measurements, are identified to push for the maximum dipole fields a REBCO accelerator magnet can generate. We discuss the research needs by reviewing the current results and outlining the perspectives for future technology development, followed by a brief update on the status of the technology development at Lawrence Berkeley National Laboratory. We present a roadmap for the next decade to develop 20 T-class REBCO accelerator magnets as an enabling instrument for future energy-frontier accelerator complex.


Author(s):  
Tim Kochem ◽  
Ananda Astrini Muhammad ◽  
Yasin Karatay ◽  
Haeyun Jin ◽  
Volker Hegelheimer

Technology-enhance language learning (TELL) continues to grow in use within language classrooms. However, a number of hurdles still remain when it comes to the effective integration of technology for skill-specific language learning, such as a lack of training and an overabundance of tools to choose from. This chapter identifies and describes three major hurdles that still plague effective TELL practices. Authors describe 2 current efforts to overcome these hurdles: a Global Online Course (GOC) on effective educational technology integration, and a year-long comparative case study on the GOC that explores the trainees' perceptions of educational technology. The chapter presents potential avenues for overcoming the above hurdles based on insights gained from four teachers of the GOC, as well as the trainees' perceptions and integration of educational technology in the language classroom.


Societies ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 41
Author(s):  
Linda Nierling ◽  
Maria Maia

Against the background of recent international regulation, the role of assistive technologies in the fields of independent living, education, and employment is analyzed in this article to propose a future strategy for a socio-technical perspective on their further development processes. Based on qualitative expert interviews at the European level, the role and scope of ATs in these fields are described for three types of disabilities: visual impairment, hearing impairment, and autism spectrum disorder. The findings show that digitalization processes entail major opportunities and challenges for ATs in all three fields and that further measures are needed to bring technical opportunities to their full potential in adverse social contexts. Regarding future technology development, the authors propose a development strategy focusing strongly on the social context of the devices. Only in this manner, relevant “unintended consequences”, as well as social or ethical concerns, can be identified and addressed.


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