Production of Artemisinin from in Vitro Cultures of Artemisia annua L.

2002 ◽  
pp. 1-12 ◽  
Author(s):  
Jorge F. S. Ferreira ◽  
Jules Janick
Keyword(s):  
Artemisia Annua ◽  
In Vitro Cultures ◽  
Artemisia Annua L

Anthelmintic activity of Artemisia annua L. extracts in vitro and the effect of an aqueous extract and artemisinin in sheep naturally infected with gastrointestinal nematodes

2014 ◽  
Vol 113 (6) ◽  
pp. 2345-2353 ◽  
Author(s):  
Aida C. Cala ◽  
Jorge F. S. Ferreira ◽  
Ana Carolina S. Chagas ◽  
Javier M. Gonzalez ◽  
Rodney A. F. Rodrigues ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
Artemisia Annua ◽  
Anthelmintic Activity ◽  
Gastrointestinal Nematodes ◽  
Artemisia Annua L

scholarly journals Toxoplasma gondii: Effects of Artemisia annua L. on susceptibility to infection in experimental models in vitro and in vivo

2009 ◽  
Vol 122 (3) ◽  
pp. 233-241 ◽  
Author(s):  
Taísa Carrijo de Oliveira ◽  
Deise A. Oliveira Silva ◽  
Cristina Rostkowska ◽  
Samantha Ribeiro Béla ◽  
Eloisa A.V. Ferro ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Artemisia Annua ◽  
Experimental Models ◽  
Susceptibility To Infection ◽  
Artemisia Annua L

scholarly journals In vitro assessment of genotoxic and cytotoxic effects of Artemisia annua L. tincture

2021 ◽  
Vol 5 (2) ◽  
pp. 1
Author(s):  
Tamara Ćetković ◽  
Anja Haverić ◽  
Lejla Čaluk Klačar ◽  
Maida Hadžić Omanović ◽  
Sanin Haverić
Keyword(s):  
Peripheral Blood ◽  
Artemisia Annua ◽  
Neutral Red ◽  
Cytotoxic Effects ◽  
Artemisia Annua L ◽  
Peripheral Blood Culture ◽  
Pharmaceutical Form ◽  
In Series ◽  
Dose Dependent

The genus Artemisia (fam. Asteraceae) is one of the largest and widely distributed with around 500 species, majority used as aromatic and medicinal plants. Artemisia annua L. is widely used as a dietary spice, herbal tea, as a supplement, and in a non-pharmaceutical form for treatment of malaria and fever. It is orally consumed as capsules, extracts and tinctures and topically applied as an essential oil diluted in lotions and ointments. Artemisinin is the main constituent of Artemisia annua L. extracts. Since the discovery that the artemisinin is efficient in malaria treatment, there is also a growth in consumption of A. annua extracts for antitumour and even recently for antiviral treatments against SARS-CoV-2 infections. This study aimed to investigate genotoxic effect in peripheral blood culture and cytotoxic effects in cancer and normal cell lines, of commercially available A. annua L. tincture in series of dilutions. Both comet and neutral red uptake assays revealed dose-dependent genotoxicity and cytotoxicity of A. annua tincture dilutions. Comet assay revealed significantly increased DNA damage in peripheral blood cells while neutral-red assays showed increase in cytotoxicity (p<0.001) in both normal and cancer cell cultures treated with the lowest extract dilution compared to the highest one applied. Obtained results indicate caution needed in A. annua L. tincture use, especially when poorly diluted.

Structural characterization and in vitro antitumor activity of A polysaccharide from Artemisia annua L. (Huang Huahao)

2019 ◽  
Vol 213 ◽  
pp. 361-369 ◽  
Author(s):  
Liang Yan ◽  
Chuan Xiong ◽  
Pan Xu ◽  
Jing Zhu ◽  
Zhirong Yang ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Structural Characterization ◽  
Artemisia Annua ◽  
Artemisia Annua L

In vitro co-cultivation of Piriformospora indica filtrate for improve biomass productivity in Artemisia annua(L.)

Symbiosis ◽  
2015 ◽  
Vol 66 (1) ◽  
pp. 37-46 ◽  
Author(s):  
Debabrat Baishya ◽  
Pori Deka ◽  
Mohan Chandra Kalita
Keyword(s):  
Artemisia Annua ◽  
Biomass Productivity ◽  
Piriformospora Indica ◽  
Artemisia Annua L

Antioxidant capacities of Artemisia annua L. leaves and enzymatically treated Artemisia annua L. in vitro and in broilers

2016 ◽  
Vol 221 ◽  
pp. 27-34 ◽  
Author(s):  
X.L. Wan ◽  
Y. Niu ◽  
X.C. Zheng ◽  
Q. Huang ◽  
W.P. Su ◽  
...  
Keyword(s):  
Artemisia Annua ◽  
Artemisia Annua L ◽  
Antioxidant Capacities

scholarly journals Artemisia annua L. extracts inhibit the in vitro replication of SARS-CoV-2 and two of its variants

2021 ◽  
pp. 114016
Author(s):  
M.S. Nair ◽  
Y. Huang ◽  
D.A. Fidock ◽  
S.J. Polyak ◽  
J. Wagoner ◽  
...  
Keyword(s):  
Artemisia Annua ◽  
Artemisia Annua L ◽  
In Vitro Replication

scholarly journals Chemical Characterization of Artemisia Annua L. Extract Assessment of Antioxidant Activity in vitro and in vivo Toxicity Studies

2019 ◽  
Vol 70 (6) ◽  
pp. 1903-1907
Author(s):  
Roxana Liana Stan ◽  
Bogdan Sevastre ◽  
Adriana Corina Hangan ◽  
Sanda Bota ◽  
Daniela Hanganu ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Artemisia Annua ◽  
Histopathological Examination ◽  
Haematological Toxicity ◽  
Chemical Characterization ◽  
In Vivo Toxicity ◽  
Artemisia Annua L ◽  
Toxicity Studies

The purpose of the study was to demonstrate in vitro antioxidant activity and in vivo toxicity of the Artemisia Annua L. extract. The plant was harvested from Bihor area (Crisul Repede and Negru river valleys), Romania. Preparation of the plant product and of the lyophilizated extract was carried out in accordance with the Romanian Pharmacopeia Xth Edition. Lyophilized extract was evaluated in terms of polyphenol content using HPLC method. Antioxidant activity was highlighted using the DPPH, ABTS and FRAP methods. Hepatic, renal and haematological toxicity studies have been performed on laboratory mice. For this purpose blood and organs were collected. Biochemical and haematological parameters were determined on the blood samples and histopathological examination was performed on organs. In vitro antioxidant effect of Artemisia Annua L extract and its lack of in vivo toxicity were demonstrated. It is desirable to obtain a new phytoproduct harvested from spontaneous flora of Romania with antioxidant / antitumoral properties and which is devoid of toxicity.

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