Fungi: A Potential Source of Anti-inflammatory Compounds

Objective: The objective of this study was to determine the anti-inflammatory activity of methanol extract of Niebuhria apetala and its possible mechanism of action. Methods: Methanol extract of Niebuhria apetala leaf (NAL) was assessed for its anti-inflammatory activity by in vitro methods. Using albumin denaturation assay, proteinase inhibitory activity, membrane stabilization, and antilipoxygenase activity at different concentrations, in vitro anti-inflammatory activity was estimated. The standard drug used for this purpose was aspirin. Results: Methanol extract NAL at a concentration range of 100–500 μg/ml significant (p<0.01) protects the heat-induced protein denaturation. At the concentration of 500 mg/ml, NAL showed significant (p<0.01) inhibition of protease inhibitory action. Heat-induced hemolysis of erythrocyte, hypotonicity-induced hemolysis, and lipooxygenase activity were significant (p<0.01) inhibited at the concentration of 500 μg/ml. Conclusion: Finally, the present study indicates that methanol extract of Niebuhria apetala can be a potential source of anti-inflammatory agent.

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Evaluation of anti-inflammatory activity of some Libyan medicinal plants in experimental animals

Archives of Biological Sciences ◽

10.2298/abs1203059e ◽

2012 ◽

Vol 64 (3) ◽

pp. 1059-1063 ◽

Cited By ~ 1

Author(s):

Jamal Elmezogi ◽

Abdulmottaleb Zetrini ◽

Ghazala Ben-Hussein ◽

Masoud Anwair ◽

Abdul Gbaj ◽

...

Keyword(s):

Medicinal Plants ◽

Significant Inhibition ◽

Inflammatory Activity ◽

Reduced Pressure ◽

Aerial Parts ◽

Potential Source ◽

Salvia Fruticosa ◽

Anti Inflammatory ◽

Thapsia Garganica ◽

First Time

Ballota pseudodictamnus (L.) Benth. (Lamiaceae), Salvia fruticosa Mill. (Lamiaceae) and Thapsia garganica L. (Apiaceae) are three well-known medicinal plants from the Libyan flora, which have long been used for the treatment of inflammations. The aim of the present study was to investigate, for the first time, the anti-inflammatory property of the methanol (MeOH) extracts of the aerial parts of these plants. Shade-dried and ground aerial parts of B. pseudodictamnus, S. fruticosa) and T. garganica were Soxhlet-extracted with MeOH. The extracts were concentrated by evaporation under reduced pressure at 40?C. The anti-inflammatory activity of the extracts was evaluated using the carrageenan-induced mice paw edema model. The administration of the extracts at a dose of 500 mg/kg body weight produced statistically significant inhibition (p < 0.05) of edema within 3 h of carrageenan administration. The results demonstrated significant anti-inflammatory properties of the test extracts. Among the extracts, the S. fruticosa extract exhibited the most significant inhibition of inflammation after 3 h (62.1%). Thus, S. fruticosa could be a potential source for the discovery and development of newer anti-inflammatory ?leads? for drug development. The anti-inflammatory activity of B. pseudodictamnus and S. fruticosa could be assumed to be related to high levels of phenolic compounds, e.g., flavonoids, present in these plants.

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Ethnopharmacological survey of Chazuta valley (Peruvian Amazon): a potential source for anti-inflammatory herbal drugs

Planta Medica ◽

10.1055/s-2007-986723 ◽

2007 ◽

Vol 73 (09) ◽

Author(s):

J Sanz-Biset ◽

J Campos de la Cruz ◽

MA Epiquién Rivera ◽

S Cañigueral

Keyword(s):

Herbal Drugs ◽

Peruvian Amazon ◽

Potential Source ◽

Anti Inflammatory

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A Comparative Study on Antioxidant and Anti-inflammatory Effects of Green Coffea arabica Beans by Country of Origin

The Korean Society of Beauty and Art ◽

10.18693/jksba.2020.21.3.281 ◽

2020 ◽

Vol 21 (3) ◽

pp. 281-293

Author(s):

Dan-Hee Yoo ◽

In-Chul Lee

Keyword(s):

Coffea Arabica ◽

Country Of Origin ◽

Ethanol Extract ◽

Natural Material ◽

Dependent Manner ◽

Concentration Dependent Manner ◽

Total Polyphenol ◽

Potential Source ◽

Anti Inflammatory ◽

Ethanol Extracts

In this study, the extracts of green Coffea arabica bean by country of origin were tested as a potential source for natural ingredients in cosmetic products. Antioxidative activities were measured by total polyphenol, 1,1-diphenyl-2-picrylhydrazyl radical (DPPH), and 2,2 -azino-bis (3- ethylbenzothiazoline-6-sulphonic acid) (ABTS) assay. Anti-inflammatory activities were checked by nitric oxide (NO) assay. The total polyphenol content was found to be higher in ethanol extract than in water extracts, and in particular Ethiopia ethanol extracts had 852.39 mg/100 g, making them the highest in content. The antioxidant measurement was measured with DPPH and ABTS, indicating that antioxidant strength increased dependent on the concentration of all extracts to be superior. The cell survival rate of the extracts of green Coffea arabica beans by country of origin was confirmed by MTT assay and was close to 100 ㎍/㎖ to 100%. Anti-inflammatory activity by NO assay showed lipopolysacchride (LPS)-induced NO was significantly inhibited following treatment with extract of green Coffea arabica beans by country of origin and decreased in a concentration-dependent manner. This study confirmed the efficacy of green Coffea arabica beans by country of origin through research related to antioxidants and anti-inflammatory, and confirmed its availability as a natural material for cosmetics.

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Mushrooms: A Potential Natural Source of Anti-Inflammatory Compounds for Medical Applications

Mediators of Inflammation ◽

10.1155/2014/805841 ◽

2014 ◽

Vol 2014 ◽

pp. 1-15 ◽

Cited By ~ 69

Author(s):

Elsayed A. Elsayed ◽

Hesham El Enshasy ◽

Mohammad A. M. Wadaan ◽

Ramlan Aziz

Keyword(s):

Chemical Structure ◽

Nutritional Value ◽

Folk Medicine ◽

Mechanisms Of Action ◽

Bioactive Metabolites ◽

Low Molecular Weight ◽

Potential Source ◽

Different Types ◽

Anti Inflammatory ◽

Different Parts

For centuries, macrofungi have been used as food and medicine in different parts of the world. This is mainly attributed to their nutritional value as a potential source of carbohydrates, proteins, amino acids, and minerals. In addition, they also include many bioactive metabolites which make mushrooms and truffles common components in folk medicine, especially in Africa, the Middle East, China, and Japan. The reported medicinal effects of mushrooms include anti-inflammatory effects, with anti-inflammatory compounds of mushrooms comprising a highly diversified group in terms of their chemical structure. They include polysaccharides, terpenoids, phenolic compounds, and many other low molecular weight molecules. The aims of this review are to report the different types of bioactive metabolites and their relevant producers, as well as the different mechanisms of action of mushroom compounds as potent anti-inflammatory agents.

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