Does Vitamin E Have a Protective Role in the Retina as an Anti-Oxidant and Free Radical Scavenger?

1987 ◽  
pp. 163-167 ◽  
Author(s):  
E. R. Berman
Keyword(s):  
Free Radical ◽  
Vitamin E ◽  
Protective Role ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Anti Oxidant

scholarly journals Possible Protective Role of Melatonin in Pediatric Infectious Diseases and Neurodevelopmental Pathologies

2020 ◽  
Vol 10 (01) ◽  
pp. e104-e109
Author(s):  
Antonio Molina-Carballo ◽  
Antonio Emilio Jerez-Calero ◽  
Antonio Muñoz-Hoyos
Keyword(s):  
Endothelial Cell ◽  
Free Radical ◽  
Chronic Administration ◽  
Protective Role ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Energetic Metabolism ◽  
Beneficial Effects ◽  
Molecular Crosstalk

AbstractMelatonin, produced in every cell that possesses mitochondria, acts as an endogenous free radical scavenger, and improves energetic metabolism and immune function, by complex molecular crosstalk with other intracellular compounds. There is greatly increasing evidence regarding beneficial effects of acute and chronic administration of high melatonin doses, in infectious, developmental, and degenerative pathologies, as an endothelial cell and every cell protectant.

scholarly journals DPPH FREE RADICAL SCAVENGER ACTIVITY OF FLAVONOID FROM THE LEAVES OF FERN Chingia sakayensis (Zeiller) Holtt

2010 ◽  
Vol 5 (2) ◽  
pp. 173-176
Author(s):  
Suyatno Suyatno ◽  
Noor Cholies Zaini ◽  
Motoo Tori
Keyword(s):  
Ascorbic Acid ◽  
Free Radical ◽  
Vitamin E ◽  
Methanol Extract ◽  
Ethyl Acetate Fraction ◽  
Free Radical Scavenger ◽  
Flavonoid Compound ◽  
Radical Scavenger ◽  
Radical Scavenger Activity ◽  
Scavenger Activity

A flavonoid compound in flavonol type namely kaemferol was isolated from the ethyl acetate fraction of the methanol extract of the fern Chingia sakayensis (Zeiller) Holtt's leaves. The DPPH free radical scavenger activity of kaemferol was stronger than buthyl hyroxy toluene (BHT) but it was weaker than ascorbic acid (vitamin C) and -tocopherol (vitamin E).   Keywords: Chingia sakayensis, kaemferol, DPPH free radical scavenger activity  

scholarly journals Hydroxy-Tyrosol as a Free Radical Scavenging Molecule in Polymeric Hydrogels Subjected to Gamma-Ray Irradiation

Processes ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 433
Author(s):  
Mauro Fiorini ◽  
Veronica Crognaletti ◽  
Omar Sabry ◽  
Lorenzo Scalise ◽  
Paolo Fattori
Keyword(s):  
Free Radical ◽  
Gamma Ray ◽  
Radical Scavenging ◽  
Free Radical Scavenging ◽  
Free Radical Scavenger ◽  
Cross Linking ◽  
Radical Scavenger ◽  
Gamma Ray Irradiation ◽  
Anti Oxidant ◽  
Polymeric Hydrogels

Biomedical engineering is employing hydrogels with increasingly exciting possibilities for the treatment and regeneration of pathologically altered, degenerated, or traumatized tissues. Still, the sterilization processes may undesirably change the chemical and physical properties of hydrogels through cross-linking reactions. This work aims to characterize a new method of producing polyethylene oxide (PEO) hydrogels exploiting hydroxy-tyrosol (HT), an anti-oxidant molecule derived from olive leaf and olive oil, as a free radical scavenger to either prevent or limit gamma-ray-induced cross-linking. For this purpose, we produced hydrogels with PEO with two different buffer solutions (phosphate and citrate), varying HT concentration. We analyzed hydrogel preparations before and after gamma-ray irradiation, assessing the viscosity through rheological analysis and the chemical changes through IR analysis. We performed high-performance liquid chromatography (HPLC) analysis to measure residual HT in hydrogels after irradiation. The obtained results show that radiation-induced cross-linking and increase in viscosity of PEO hydrogels can be prevented by tailoring the concentration of HT as a free radical scavenging agent. Irradiation only consumes small amounts of HT; its presence in polymeric hydrogels can significantly impact biomedical applications by its anti-oxidant and anti-microbial activities.

scholarly journals Vitamin E Prevents Cold Wrap Restraint Stress-Induced Intestinal Fluid Transport Alterations in Rats

1994 ◽  
Vol 8 (7) ◽  
pp. 417-421 ◽  
Author(s):  
Scott Burdick ◽  
Ningren Cui ◽  
Lonnie R Empey ◽  
Richard N Fedorak
Keyword(s):  
Free Radical ◽  
Vitamin E ◽  
Restraint Stress ◽  
Fluid Transport ◽  
Radical Scavenging ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Intestinal Fluid ◽  
Fluid Absorption

Psychological stress may alter gastrointestinal absorptive function by increasing the quantity of intestinal free radicals or by lowering endogenous intestinal free radical scavenging capacity. Vitamin E has been shown to be a potent endogenous antioxidant and free radical scavenger under both physiological and pathological conditions. The purpose of this study was to determine whether cold wrap restraint stress altered in vivo intestinal fluid absorption in rats, and whether vitamin E administration prior to the induction of cold wrap restraint stress could prevent such changes in intestinal secretion. Jejunal, ileal and colonic fluid and electrolyte transport rates were measured in vivo using an isolated loop technique. Cold wrap restraint stress reduced in vivo fluid absorption in the ileum and colon, but not in the jejunum. Administration of vitamin E prior to the cold wrap restraint stress procedure completely prevented this alteration of ileal and colonic fluid absorption.

scholarly journals Antioxidant Function and Health Implications of Vitamin E

2013 ◽  
Vol 7 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Ching Kuang Chow ◽  
Hannah S Chow-Johnson
Keyword(s):  
Vitamin E ◽  
Large Scale ◽  
Biological Response ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Cellular Events ◽  
Degenerative Disorders ◽  
Antioxidant Function ◽  
Anti Oxidant ◽  
High Doses

Superoxide, a key precursor of important reactive oxygen/nitrogen species (ROS/RNS), may release iron from its protein complex. By mediating the generation and/level of superoxide, vitamin E, the most important fat-soluble anti-oxidant and free radical scavenger, may exert its antioxidant function by limiting the formation of reactive hydroxyl radi-cals and peroxynitrite. The antioxidant function of vitamin E is augmented by GSH peroxidase and related metabolic sys-tems which respond adaptively and compensatively to oxidative stress. By mediating the levels of ROS/RNS, vitamin E may also modulate the activation and/or expression of redox-sensitive biological response modifiers, and thereby attenu-ate the cellular events leading to the onset and development of aging and other degenerative disorders. Earlier epidemiol-ogical data and retrospective studies show an association between increased intake of vitamin E and reduced risk of car-diovascular disease, cancer, and other disorders. However, subsequent prospective randomized placebo-controlled studies and interventional trials have provided inconsistent findings. Data available from recent large-scale interventional trials suggest that vitamin E supplements at high doses are not beneficial.

scholarly journals RNAi-mediated knockdown of MTNR1B without disrupting the effects of melatonin on apoptosis and cell cycle in bovine granulose cells

PeerJ ◽  
2018 ◽  
Vol 6 ◽  
pp. e4463 ◽  
Author(s):  
Wenju Liu ◽  
Shujuan Wang ◽  
Jinxing Zhou ◽  
Xunsheng Pang ◽  
Like Wang
Keyword(s):  
Cell Cycle ◽  
Free Radical ◽  
Granulosa Cells ◽  
Cell Apoptosis ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Anti Oxidant ◽  
Granulose Cells ◽  
Apoptotic Pathways

Melatonin is well known as a powerful free radical scavenger and exhibits the ability to prevent cell apoptosis. In the present study, we investigated the role of melatonin and its receptor MTNR1B in regulating the function of bovine granulosa cells (GCs) and hypothesized the involvement of MTNR1B in mediating the effect of melatonin on GCs. Our results showed that MTNR1B knockdown significantly promoted GCs apoptosis but did not affect the cell cycle. These results were further verified by increasing the expression of pro-apoptosis genes (BAX and CASP3), decreasing expression of the anti-apoptosis genes (BCL2 and BCL-XL) and anti-oxidant genes (SOD1 and GPX4) without affecting cell cycle factors (CCND1, CCNE1 and CDKN1A) and TP53. In addition, MTNR1B knockdown did not disrupt the effects of melatonin in suppressing the GCs apoptosis or blocking the cell cycle. Moreover, MTNR1B knockdown did not affect the role of melatonin in increasing BCL2, BCL-XL, and CDKN1A expression, or decreasing BAX, CASP3, TP53, CCND1 and CCNE1 expression. The expression of MTNR1A was upregulated after MTNR1B knockdown, and melatonin promoted MTNR1A expression with or without MTNR1B knockdown. However, despite melatonin supplementation, the expression of SOD1 and GPX4 was still suppressed after MTNR1B knockdown. In conclusion, these findings indicate that melatonin and MTNR1B are involved in BCL2 family and CASP3-dependent apoptotic pathways in bovine GCs. MTNR1A and MTNR1B may coordinate the work of medicating the appropriate melatonin responses to GCs.

OPTIMASI KONDISI EKSTRAKSI SENYAWA AKTIF ANTIOKSIDAN DARI BIJI ANGGUR

2019 ◽  
Vol 3 (2) ◽  
pp. 35
Author(s):  
Kartini Kartini ◽  
Azminah Azminah
Keyword(s):  
Free Radical ◽  
Optimum Condition ◽  
Active Compound ◽  
Grape Seed ◽  
Free Radical Scavenger ◽  
Water Bath ◽  
Radical Scavenger ◽  
Optimum Conditions ◽  
Ethanolic Solution ◽  
Reduced Pressure

In order to prepare standardized extract, optimization of extraction conditions of grape seed has been done. These conditions are type of menstrum (50, 70 and 96% of ethanolic solution), length of extraction (1, 2 and 4 hours) also method of evaporation (reduced pressure and opened air). Activity on free radical scavenger used as parameters to determine optimum conditions. Based on EC50 (concentration which scavenge 50% amount of free radical) can be concluded that optimum condition for extracting antioxidant active compound from grape seed are 70% ethanolic solution as menstrum, length of extraction 1 hour and evaporation on opened air use water bath.

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