Beta-Thromboglobulin, Platelet Factor 4 and Coronary Heart Disease

1984 ◽  
pp. 310-317
Author(s):  
E. Pelissier ◽  
M. Baillet ◽  
C. Tzincoca ◽  
E. Terrier
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Platelet Factor 4 ◽  
Platelet Factor

Elevated platelet factor 4 and β-thromboglobulin plasma levels in depressed patients with ischemic heart disease

1997 ◽  
Vol 42 (4) ◽  
pp. 290-295 ◽  
Author(s):  
Fouzia Laghrissi-Thode ◽  
William R. Wagner ◽  
Bruce G. Pollock ◽  
Peter C. Johnson ◽  
Mitchell S. Finkel
Keyword(s):  
Heart Disease ◽  
Ischemic Heart Disease ◽  
Plasma Levels ◽  
Platelet Factor 4 ◽  
Ischemic Heart ◽  
Platelet Factor ◽  
Depressed Patients

scholarly journals Fibrinopeptide A, platelet factor 4, and beta-thromboglobulin levels in coronary heart disease

Blood ◽  
1982 ◽  
Vol 60 (3) ◽  
pp. 650-654
Author(s):  
AB Nichols ◽  
J Owen ◽  
KL Kaplan ◽  
RR Sciacca ◽  
PJ Cannon ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Left Ventricular ◽  
Platelet Factor 4 ◽  
Fibrinopeptide A ◽  
Platelet Factor ◽  
Artery Disease ◽  
Regional Dysfunction

In vivo platelet alpha-granule release and fibrin I formation were measured in 82 patients with ischemic heart disease by radioimmunoassay of platelet factor 4, beta-thromboglobulin, and fibrinopeptide A. The presence and extent of coronary artery disease were determined by coronary arteriography, and the extent of left ventricular regional dysfunction was assessed by contrast left ventriculography. In patients with abnormal coronary arteriograms without previous myocardial infarction, mean levels of platelet factor 4, beta-thromboglobulin, and fibrinopeptide A were not elevated. In patients in whom myocardial infarction had occurred more than 6 mo previously, platelet factor 4 (8.3 ng/ml; p less than 0.01) and beta-thromboglobulin (33.2 ng/ml; p less than 0.001) levels were significantly elevated, but fibrinopeptide A levels were normal. Levels of platelet factor 4 and beta- thromboglobulin were unrelated to the extent of coronary artery disease. In the patients with prior infarction, beta-thromboglobulin correlated directly with extent of left ventricular regional dysfunction (r = 0.53; p less than 0.01) and inversely with ejection fraction (r = -056; p less than 0.05). In a small group of patients with left ventricular aneurysm, mean fibrinopeptide A levels were also elevated. We interpret these findings as indicating that platelet release in patients with ischemic heart disease results from platelet reaction with previously infarcted myocardium rather than with the atherosclerotic coronary arteries.

scholarly journals Fibrinopeptide A, platelet factor 4, and beta-thromboglobulin levels in coronary heart disease

Blood ◽  
1982 ◽  
Vol 60 (3) ◽  
pp. 650-654 ◽  
Author(s):  
AB Nichols ◽  
J Owen ◽  
KL Kaplan ◽  
RR Sciacca ◽  
PJ Cannon ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Coronary Artery Disease ◽  
Heart Disease ◽  
Coronary Artery ◽  
Left Ventricular ◽  
Platelet Factor 4 ◽  
Fibrinopeptide A ◽  
Platelet Factor ◽  
Artery Disease ◽  
Regional Dysfunction

Abstract In vivo platelet alpha-granule release and fibrin I formation were measured in 82 patients with ischemic heart disease by radioimmunoassay of platelet factor 4, beta-thromboglobulin, and fibrinopeptide A. The presence and extent of coronary artery disease were determined by coronary arteriography, and the extent of left ventricular regional dysfunction was assessed by contrast left ventriculography. In patients with abnormal coronary arteriograms without previous myocardial infarction, mean levels of platelet factor 4, beta-thromboglobulin, and fibrinopeptide A were not elevated. In patients in whom myocardial infarction had occurred more than 6 mo previously, platelet factor 4 (8.3 ng/ml; p less than 0.01) and beta-thromboglobulin (33.2 ng/ml; p less than 0.001) levels were significantly elevated, but fibrinopeptide A levels were normal. Levels of platelet factor 4 and beta- thromboglobulin were unrelated to the extent of coronary artery disease. In the patients with prior infarction, beta-thromboglobulin correlated directly with extent of left ventricular regional dysfunction (r = 0.53; p less than 0.01) and inversely with ejection fraction (r = -056; p less than 0.05). In a small group of patients with left ventricular aneurysm, mean fibrinopeptide A levels were also elevated. We interpret these findings as indicating that platelet release in patients with ischemic heart disease results from platelet reaction with previously infarcted myocardium rather than with the atherosclerotic coronary arteries.

Hearing loss and coronary heart disease

JAMA ◽  
1965 ◽  
Vol 194 (4) ◽  
pp. 452b-452
Keyword(s):  
Coronary Heart Disease ◽  
Hearing Loss ◽  
Heart Disease
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