Discussion on Specificity of Molecular Signals in Response to Certain Environmental Toxicants or Stresses

2019 ◽  
pp. 327-349
Author(s):  
Dayong Wang
Keyword(s):  
Environmental Toxicants ◽  
Molecular Signals

Troubling Figures

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Logan Natalie O'Laughlin
Keyword(s):  
Critical Discourse Analysis ◽  
Science Studies ◽  
Critical Discourse ◽  
People Of Color ◽  
Careful Examination ◽  
Environmental Toxicants ◽  
Environmental Racism ◽  
Feminist Science Studies ◽  
Feminist Science ◽  
Do So

This essay examines the figure of the pesticide-exposed intersex frog, a canary in the coal mine for public endocrinological health. Through feminist science studies and critical discourse analysis, I explore the fields that bring this figure into being (endocrinology, toxicology, and pest science) and the colonial and racial logics that shape these fields. In so doing, I attend to the multiple nonhuman actors shaping this figure, including the pesky weeds and insects who prompt pesticides’ very existence, “male” frogs who function as test subjects, and systemic environmental racism that disproportionately exposes people of color to environmental toxicants. I encourage careful examination of galvanizing environmental figures like this toxic intersex frog and I offer a method to do so.

Mechanistic Overview of Immune Modulatory Effects of Environmental Toxicants

2015 ◽  
Vol 13 (6) ◽  
pp. 382-386 ◽  
Author(s):  
Haji Bahadar ◽  
Mohammad Abdollahi ◽  
Faheem Maqbool ◽  
Maryam Baeeri ◽  
Kamal Niaz
Keyword(s):  
Environmental Toxicants

scholarly journals A predictive in vitro risk assessment platform for pro-arrhythmic toxicity using human 3D cardiac microtissues

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Celinda M. Kofron ◽  
Tae Yun Kim ◽  
Fabiola Munarin ◽  
Arvin H. Soepriatna ◽  
Rajeev J. Kant ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Action Potentials ◽  
Induced Pluripotent Stem Cell ◽  
Human Action ◽  
Environmental Toxicants ◽  
Pharmaceutical Drugs ◽  
Industrial Chemicals ◽  
Endocrine Disrupting Chemical

AbstractCardiotoxicity of pharmaceutical drugs, industrial chemicals, and environmental toxicants can be severe, even life threatening, which necessitates a thorough evaluation of the human response to chemical compounds. Predicting risks for arrhythmia and sudden cardiac death accurately is critical for defining safety profiles. Currently available approaches have limitations including a focus on single select ion channels, the use of non-human species in vitro and in vivo, and limited direct physiological translation. We have advanced the robustness and reproducibility of in vitro platforms for assessing pro-arrhythmic cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes and human cardiac fibroblasts in 3-dimensional microtissues. Using automated algorithms and statistical analyses of eight comprehensive evaluation metrics of cardiac action potentials, we demonstrate that tissue-engineered human cardiac microtissues respond appropriately to physiological stimuli and effectively differentiate between high-risk and low-risk compounds exhibiting blockade of the hERG channel (E4031 and ranolazine, respectively). Further, we show that the environmental endocrine disrupting chemical bisphenol-A (BPA) causes acute and sensitive disruption of human action potentials in the nanomolar range. Thus, this novel human 3D in vitro pro-arrhythmic risk assessment platform addresses critical needs in cardiotoxicity testing for both environmental and pharmaceutical compounds and can be leveraged to establish safe human exposure levels.

Molecular signals versus the Loi de Balancement

2001 ◽  
Vol 16 (1) ◽  
pp. 24-29 ◽  
Author(s):  
Armand M. Leroi
Keyword(s):  
Molecular Signals

scholarly journals Glycans in autophagy, endocytosis and lysosomal functions

2021 ◽  
Author(s):  
Fulvio Reggiori ◽  
Hans-Joachim Gabius ◽  
Massimo Aureli ◽  
Winfried Römer ◽  
Sandro Sonnino ◽  
...  
Keyword(s):  
Sugar Code ◽  
Endogenous Lectins ◽  
Biological Aspects ◽  
Molecular Signals ◽  
Lysosomal Proteins ◽  
In Cells

AbstractGlycans have been shown to function as versatile molecular signals in cells. This prompted us to look at their roles in endocytosis, endolysosomal system and autophagy. We start by introducing the cell biological aspects of these pathways, the concept of the sugar code, and provide an overview on the role of glycans in the targeting of lysosomal proteins and in lysosomal functions. Moreover, we review evidence on the regulation of endocytosis and autophagy by glycans. Finally, we discuss the emerging concept that cytosolic exposure of luminal glycans, and their detection by endogenous lectins, provides a mechanism for the surveillance of the integrity of the endolysosomal compartments, and serves their eventual repair or disposal.

Dysregulation of G protein-coupled receptors in the intestine by nanoplastic exposure in Caenorhabditis elegans

2021 ◽  
Author(s):  
Yunhan Yang ◽  
Qiuli Wu ◽  
Dayong Wang
Keyword(s):  
Caenorhabditis Elegans ◽  
G Protein ◽  
G Protein Coupled Receptors ◽  
Environmental Toxicants ◽  
G Protein Coupled

After the uptake, the environmental toxicants may cause the toxicity on organisms by activating or inhibiting certain G protein-coupled receptors (GPCRs). Nevertheless, the roles of GPCRs in mediating the response...

scholarly journals Cytotoxic Effects of N,N-Diethyl-Meta-Toluamide (DEET) on Sinonasal Epithelia

OTO Open ◽  
2021 ◽  
Vol 5 (2) ◽  
pp. 2473974X2110092
Author(s):  
Jivianne T. Lee ◽  
Saroj Basak
Keyword(s):  
Cell Viability ◽  
Chronic Rhinosinusitis ◽  
Morphological Changes ◽  
Environmental Toxicants ◽  
Cytotoxic Effects ◽  
Airborne Pollutants ◽  
Cell Monitoring ◽  
History Of ◽  
And Control ◽  
Dose Dependent

Although the etiology of chronic rhinosinusitis remains unknown, environmental factors including airborne pollutants and toxicants are postulated to contribute to its pathogenesis. However, the precise pathomechanisms with which environmental toxicants may contribute to chronic rhinosinusitis are not fully understood. The purpose of this pilot study is to examine the cytotoxic effects of N,N-diethyl- meta-toluamide (DEET), a commonly used pesticide, on sinonasal epithelial cells (SNECs). Sinus mucosa was obtained from 3 subjects without a history of chronic rhinosinusitis. Cultured SNECs were exposed to various concentrations of DEET (0-5 mM) for 6 days. Cell viability, proliferation, and morphologic changes were assessed using the MTT colorimetric dye assay and the Incucyte Live Cell Monitoring System. Statistically significant dose-dependent reduction in cell viability and proliferation was observed between exposure and control groups ( P < .05) at all concentrations tested. Dose-dependent cellular morphological changes were also seen. These findings indicate that DEET exposure induces dose-dependent cytotoxicity in sinonasal epithelia.

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