Aptamer: Apt System for Target-Specific Drug Delivery

Aptamers ◽  
2019 ◽  
pp. 59-71
Author(s):  
Meenu Goyal ◽  
Citu ◽  
Nidhi Singh ◽  
Varsha Singla ◽  
Ankit Singla
Keyword(s):  
Drug Delivery ◽  
Specific Drug

Cancer Nanotheranostics: A Nanomedicinal Approach for Cancer Therapy and Diagnosis

2020 ◽  
Vol 20 (11) ◽  
pp. 1288-1299
Author(s):  
Paromita Kundu ◽  
Deepika Singh ◽  
Abhalaxmi Singh ◽  
Sanjeeb K. Sahoo
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Cancer Diagnosis ◽  
Specific Drug ◽  
Novel Therapies ◽  
Future Directions ◽  
Normal Tissues ◽  
Cancer Management ◽  
Single Probe ◽  
Therapy And Diagnosis

The panorama of cancer treatment has taken a considerable leap over the last decade with the advancement in the upcoming novel therapies combined with modern diagnostics. Nanotheranostics is an emerging science that holds tremendous potential as a contrivance by integrating therapy and imaging in a single probe for cancer diagnosis and treatment thus offering the advantage like tumor-specific drug delivery and at the same time reduced side effects to normal tissues. The recent surge in nanomedicine research has also paved the way for multimodal theranostic nanoprobe towards personalized therapy through interaction with a specific biological system. This review presents an overview of the nano theranostics approach in cancer management and a series of different nanomaterials used in theranostics and the possible challenges with future directions.

Design and Optimization of Chronotherapeutic Dosage Form for the Treatment of Angina Pectoris

2020 ◽  
Vol 10 ◽  
Author(s):  
Rupali Singh ◽  
Rishabha Malviya
Keyword(s):  
Drug Delivery ◽  
Angina Pectoris ◽  
Ethyl Cellulose ◽  
Dosage Form ◽  
Cellulose Solution ◽  
Specific Drug ◽  
Pharmaceutical Dosage Form ◽  
Weight Variation ◽  
Short Period ◽  
Time Specific

Background: The chronotherapy concept attains considerable focus towards itself due to its pulsatile fashion rather than continuous delivery. The delivery of the right amount of drug to the target organ at the most appropriate time is fulfilled by using the chronotherapeutic dosage form. Aim: The present study aims to develop and evaluate a chronotherapeutic drug delivery system by using natural polymer for time specific drug delivery at the target site. Material and Method: Tamarind seed polysaccharide was extracted and used in the preparation of core tablets. Nine formulations of core tablets were prepared with nifedipine at 5 tonnes of pressure on 6 mm punch. The core tablets were prepared by using the compression coating method. The three batches F1, F2 and F3 were prepared by using tamarind gum in different concentration i.e. 45%, 22.5% and 67.5% respectively and compressed at 8 tonnes of pressure on 12 mm of punch. The finally compressed tablet was coated with different concentrations of ethyl cellulose in which isopropyl alcohol used as a solvent. In a controlled medium, a stability study was performed to evaluate the physical appearance, drug content and release of the prepared core tablet. Result: All the nine formulations of tablets were prepared successfully and the evaluation studies (thickness, weight variation, hardness, friability etc.) revealed that all the formulations were within the official range. The release study of the drug revealed that the formulation F7 containing 67.5% of tamarind polymer, coated with 2%, 4% and 5% of ethyl cellulose solution released 59.68±1.03% (Q50%) drug within 5 h whereas, 87.09±2.08% (Q80%) within 6 h and within 12 h 97.74±2.19% of the drug was released. The formulation F7 was found to be more effective as it released the maximum amount of drug in a short period as compared with other formulations. Conclusion: The coating of core tablets allowed to prepare pharmaceutical dosage form for time specific drug delivery. These chronotherapeutic core tablets can be used for the treatment of angina pectoris and hypertension etc.

scholarly journals Vascular Lesion–Specific Drug Delivery Systems

2021 ◽  
Vol 77 (19) ◽  
pp. 2413-2431
Author(s):  
David Marlevi ◽  
Elazer R. Edelman
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Vascular Lesion ◽  
Delivery Systems ◽  
Specific Drug

Pharmaceutical Calculations — A Basic Review

2002 ◽  
Vol 18 (5) ◽  
pp. 257-259
Author(s):  
Nicole M Russo
Keyword(s):  
Drug Delivery ◽  
Pharmaceutical Preparation ◽  
Medication Administration ◽  
Patient Specific ◽  
Specific Drug ◽  
Mathematical Concepts ◽  
Data Synthesis ◽  
Drug Concentrations ◽  
Data Source ◽  
Stock Solutions

Objective: To review mathematical topics used in pharmaceutical preparation, specifically ratios and proportions, percentage concentrations, and stock solutions. Data Source: Online pharmaceutics sources and current pharmaceutics textbooks were consulted. Data Synthesis: Ratios and proportions are basic tools for adjusting drug concentrations. Using proportions, medications can be provided in any concentration desired. By extending this technique to percentage concentrations, prescriptions can be interpreted and calculated. In the same manner, the ability to dilute stock solutions provides patient-specific drug delivery. Conclusions: The mathematical concepts of ratios and proportions, percentage concentrations, and stock dilutions are essential for correct medication administration in any setting.

Smart nanocomposite hydrogels based on azo crosslinked graphene oxide for oral colon-specific drug delivery

2016 ◽  
Vol 27 (31) ◽  
pp. 315105 ◽  
Author(s):  
Lin Hou ◽  
Yuyang Shi ◽  
Guixiang Jiang ◽  
Wei Liu ◽  
Huili Han ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Specific Drug ◽  
Nanocomposite Hydrogels ◽  
Colon Specific Drug Delivery

Phosphated crosslinked pectin as a potential excipient for specific drug delivery: preparation and physicochemical characterization

2009 ◽  
Vol 59 (1) ◽  
pp. 127-135 ◽  
Author(s):  
João Fhilype Andrade Souto-Maior ◽  
Adriano Valim Reis ◽  
Liliane Neves Pedreiro ◽  
Osvaldo Albuquerque Cavalcanti
Keyword(s):  
Drug Delivery ◽  
Physicochemical Characterization ◽  
Specific Drug
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