Accurate information about groundwater level prediction is crucial for effective planning and management of groundwater resources. In the present study, the Artificial Neural Network (ANN), optimized with a Genetic Algorithm (GA-ANN), was employed for seasonal groundwater table depth (GWTD) prediction in the area between the Ganga and Hindon rivers located in Uttar Pradesh State, India. A total of 18 models for both seasons (nine for the pre-monsoon and nine for the post-monsoon) have been formulated by using groundwater recharge (GWR), groundwater discharge (GWD), and previous groundwater level data from a 21-year period (1994–2014). The hybrid GA-ANN models’ predictive ability was evaluated against the traditional GA models based on statistical indicators and visual inspection. The results appraisal indicates that the hybrid GA-ANN models outperformed the GA models for predicting the seasonal GWTD in the study region. Overall, the hybrid GA-ANN-8 model with an 8-9-1 structure (i.e., 8: inputs, 9: neurons in the hidden layer, and 1: output) was nominated optimal for predicting the GWTD during pre- and post-monsoon seasons. Additionally, it was noted that the maximum number of input variables in the hybrid GA-ANN approach improved the prediction accuracy. In conclusion, the proposed hybrid GA-ANN model’s findings could be readily transferable or implemented in other parts of the world, specifically those with similar geology and hydrogeology conditions for sustainable planning and groundwater resources management.