Screening Experimental Designs and Their Applications in Pharmaceutical Development

2021 ◽  
pp. 15-26
Author(s):  
Sarwar Beg
Keyword(s):  
Experimental Designs ◽  
Pharmaceutical Development

Effect of Computerized Auditory Training on Speech Perception of Adults With Hearing Impairment

2013 ◽  
Vol 20 (3) ◽  
pp. 91-106 ◽  
Author(s):  
Rachel Pizarek ◽  
Valeriy Shafiro ◽  
Patricia McCarthy
Keyword(s):  
Hearing Loss ◽  
Speech Perception ◽  
Literature Review ◽  
Low Cost ◽  
Experimental Designs ◽  
Auditory Training ◽  
Hearing Impairments ◽  
Communicative Disorders ◽  
And Training

Computerized auditory training (CAT) is a convenient, low-cost approach to improving communication of individuals with hearing loss or other communicative disorders. A number of CAT programs are being marketed to patients and audiologists. The present literature review is an examination of evidence for the effectiveness of CAT in improving speech perception in adults with hearing impairments. Six current CAT programs, used in 9 published studies, were reviewed. In all 9 studies, some benefit of CAT for speech perception was demonstrated. Although these results are encouraging, the overall quality of available evidence remains low, and many programs currently on the market have not yet been evaluated. Thus, caution is needed when selecting CAT programs for specific patients. It is hoped that future researchers will (a) examine a greater number of CAT programs using more rigorous experimental designs, (b) determine which program features and training regimens are most effective, and (c) indicate which patients may benefit from CAT the most.

Water Tunnel to test and characterization of experimental designs of Hydrokinetics Turbines

2018 ◽  
Vol 1 (6) ◽  
Author(s):  
Eduardo Alvarez-Alvarez ◽  
Aitor Fernandez-Jimenez ◽  
Manuel Rico-Secades ◽  
Antonio Javier Calleja-Rodriguez ◽  
Joaquin Fernandez-Francos ◽  
...  
Keyword(s):  
Experimental Designs ◽  
Water Tunnel

Total Synthesis of Axially-Chiral Cannabinols: A New Platform for Cannabinoid-Based Drug Discovery

2019 ◽  
Author(s):  
Primali Navaratne ◽  
Jenny Wilkerson ◽  
Kavindri Ranasinghe ◽  
Evgeniya Semenova ◽  
Lance McMahon ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Total Synthesis ◽  
Ground State ◽  
Chemical Space ◽  
Modern Medicine ◽  
The Novel ◽  
Pharmaceutical Development ◽  
Bioactive Component ◽  
Axially Chiral ◽  
New Directions

<div> <div> <div> <p>Phytocannabinoids, molecules isolated from cannabis, are gaining attention as promising leads in modern medicine, including pain management. Considering the urgent need for combating the opioid crisis, new directions for the design of cannabinoid-inspired analgesics are of immediate interest. In this regard, we have hypothesized that axially-chiral-cannabinols (ax-CBNs), unnatural (and unknown) isomers of cannabinol (CBN) may be valuable scaffolds for cannabinoid-inspired drug discovery. There are multiple reasons for thinking this: (a) ax-CBNs would have ground-state three-dimensionality akin to THC, a key bioactive component of cannabis, (b) ax-CBNs at their core structure are biaryl molecules, generally attractive platforms for pharmaceutical development due to their ease of functionalization and stability, and (c) atropisomerism with respect to phytocannabinoids is unexplored “chemical space.” Herein we report a scalable total synthesis of ax-CBNs, examine physical properties experimentally and computationally, and provide preliminary behavioral and analgesic analysis of the novel scaffolds. </p> </div> </div> </div>

Revisiting Glycerol Esterification with Acetic Acid over Amberlyst-35 via Statistically Designed Experiments: Overcoming Transport Limitations

2019 ◽  
Author(s):  
Víctor Gabriel Baldovino Medrano ◽  
Karen V. Caballero ◽  
Hernando Guerrero-Amaya
Keyword(s):  
Acetic Acid ◽  
Active Sites ◽  
Batch Reactor ◽  
Catalyst Particle ◽  
Experimental Designs ◽  
Particle Sizes ◽  
Turnover Rates ◽  
Designed Experiments ◽  
Different Temperatures ◽  
Glycerol Esterification

Turnover rates for glycerol esterification with acetic acid over Amberlyst-35 were measured under different temperatures, reactants and active sites concentrations, and catalyst particle sizes. Data were collected in a batch reactor. Experiments were done following a sequence of factorial experimental designs.

COMPARISON OF DIFFERENT EXPERIMENTAL DESIGNS, SAMPLE SIZES AND TECHNIQUES APPLIED TO METAMODELING THE INDUCED DRAG COEFFICIENT OF A BOX-WING AIRCRAFT

2018 ◽  
Author(s):  
Luiz Fernando Tibério Fernandez ◽  
Guilherme Barufaldi ◽  
Adson De Paula ◽  
Luiz Carlos Sandoval
Keyword(s):  
Drag Coefficient ◽  
Experimental Designs ◽  
Sample Sizes ◽  
Induced Drag

Q-optimal experimental designs and close to them experimental designs for polynomial regression on the interval

2020 ◽  
Vol 86 (5) ◽  
pp. 65-72
Author(s):  
Yu. D. Grigoriev
Keyword(s):  
Optimal Design ◽  
Polynomial Regression ◽  
Direct Consequence ◽  
Experimental Designs ◽  
Optimal Designs ◽  
Software Systems ◽  
General Character ◽  
Support Points ◽  
Optimal Weights ◽  
Universal Expression

The problem of constructing Q-optimal experimental designs for polynomial regression on the interval [–1, 1] is considered. It is shown that well-known Malyutov – Fedorov designs using D-optimal designs (so-called Legendre spectrum) are other than Q-optimal designs. This statement is a direct consequence of Shabados remark which disproved the Erdős hypothesis that the spectrum (support points) of saturated D-optimal designs for polynomial regression on a segment appeared to be support points of saturated Q-optimal designs. We present a saturated exact Q-optimal design for polynomial regression with s = 3 which proves the Shabados notion and then extend this statement to approximate designs. It is shown that when s = 3, 4 the Malyutov – Fedorov theorem on approximate Q-optimal design is also incorrect, though it still stands for s = 1, 2. The Malyutov – Fedorov designs with Legendre spectrum are considered from the standpoint of their proximity to Q-optimal designs. Case studies revealed that they are close enough for small degrees s of polynomial regression. A universal expression for Q-optimal distribution of the weights pi for support points xi for an arbitrary spectrum is derived. The expression is used to tabulate the distribution of weights for Malyutov – Fedorov designs at s = 3, ..., 6. The general character of the obtained expression is noted for Q-optimal weights with A-optimal weight distribution (Pukelsheim distribution) for the same problem statement. In conclusion a brief recommendation on the numerical construction of Q-optimal designs is given. It is noted that in this case in addition to conventional numerical methods some software systems of symbolic computations using methods of resultants and elimination theory can be successfully applied. The examples of Q-optimal designs considered in the paper are constructed using precisely these methods.

PENGARUH MODEL PEMBELAJARAN MARIA MONTESSORI TERHADAP PENGEMBANGAN KEDISIPLINAN ANAK USIA 4-5 TAHUN DI TK ISLAM IBNU QOYYIM KEC. MEDAN SELAYANG

2019 ◽  
Vol 7 (2) ◽  
Author(s):  
Fatma Gustina ◽  
Khadijah Khadijah ◽  
Fauziah Nasution
Keyword(s):  
Hypothesis Testing ◽  
Experimental Research ◽  
Learning Model ◽  
Experimental Designs ◽  
Maria Montessori ◽  
Post Test ◽  
Quasi Experimental ◽  
Group A

<p><em>This research was conducted at TK Islam Ibnu Qoyyim, Medan Selayang District. Tthe type of research is experimental research with uses Quasi Experimental Designs. This study aims to determine the influence of Maria Montessori's learning model on the discipline of children in TK Islam Ibnu Qoyyim. The results showed that the Montessori learning model had an effect on the discipline of group A children. The results of the pretest class were 9.3 and the post-test average was 16.80 with the highest post-test 20 and the lowest post-test 12. Class control with an average pre test 9.7 and the average post test 11.7 with the highest value 16 and the lowest value 7. The results of hypothesis testing obtained t count&gt; t table is 18.31&gt; 2.048 with significant numbers. Thus the hypothesis Ho is rejected and Ha is accepted so that it is stated that there is a Significant Effect of Maria Montessori's Learning Model on the Discipline of Group A Children 4-5 Years Old in the TK Islam Ibnu Qoyyim.</em><em></em></p>

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