Vitamin E concentration in breast adipose tissue of breast cancer patients (Kuopio, Finland)

1996 ◽  
Vol 7 (6) ◽  
pp. 591-595 ◽  
Author(s):  
Zhenrong Zhu ◽  
Markku Parviainen ◽  
Satu M�nnist� ◽  
Pirjo Pietinen ◽  
Matti Eskelinen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adipose Tissue ◽  
Vitamin E ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Breast Adipose Tissue ◽  
Breast Adipose

Abstract C074: Presence of crown-like structures in breast adipose tissue and clinical outcomes among African-American and White breast cancer patients

2020 ◽  
Author(s):  
Aswathy M Cheriyan ◽  
Mark E Sherman ◽  
Yuan Liu ◽  
Keerthi Gogineni ◽  
Jiaqi Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adipose Tissue ◽  
African American ◽  
Cancer Patients ◽  
Clinical Outcomes ◽  
Breast Cancer Patients ◽  
Breast Adipose Tissue ◽  
Breast Adipose

Fatty acid composition of breast adipose tissue in breast cancer patients and in patients with benign breast disease

1995 ◽  
Vol 24 (2) ◽  
pp. 151-160 ◽  
Author(s):  
Z. R. Zhu ◽  
J. Ågren ◽  
S. Männistö ◽  
P. Pietinen ◽  
M. Eskelinen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adipose Tissue ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Cancer Patients ◽  
Benign Breast Disease ◽  
Breast Disease ◽  
Breast Cancer Patients ◽  
Breast Adipose Tissue ◽  
Breast Adipose

Conjugated Linoleic Acid Content in Breast Adipose Tissue of Breast Cancer Patients and the Risk of Metastasis

2003 ◽  
Vol 45 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Véronique Chajès ◽  
Flore Lavillonnière ◽  
Virginie Maillard ◽  
Bruno Giraudeau ◽  
Marie-Lise Jourdan ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adipose Tissue ◽  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Cancer Patients ◽  
Acid Content ◽  
Linoleic Acid Content ◽  
Breast Cancer Patients ◽  
Breast Adipose Tissue ◽  
Breast Adipose

scholarly journals Prognostic Significance of CT-Attenuation of Tumor-Adjacent Breast Adipose Tissue in Breast Cancer Patients with Surgical Resection

Cancers ◽  
2019 ◽  
Vol 11 (8) ◽  
pp. 1135 ◽  
Author(s):  
Jeong Won Lee ◽  
Sung Yong Kim ◽  
Hyun Ju Lee ◽  
Sun Wook Han ◽  
Jong Eun Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adipose Tissue ◽  
Cancer Patients ◽  
Prognostic Significance ◽  
Breast Cancer Patients ◽  
Pet Ct ◽  
Ct Attenuation ◽  
Breast Adipose Tissue ◽  
Breast Adipose ◽  
Attenuation Values

The purpose of this study was to evaluate the prognostic significance of computed tomography (CT)-attenuation of tumor-adjacent breast adipose tissue for predicting recurrence-free survival (RFS) in patients with breast cancer. We retrospectively enrolled 287 breast cancer patients who underwent pretreatment 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT. From non-contrast-enhanced CT images of PET/CT, CT-attenuation values of tumor-adjacent breast adipose tissue (TAT HU) and contralateral breast adipose tissue (CAT HU) were measured. Difference (HU difference) and percent difference (HU difference %) in CT-attenuation values between TAT HU and CAT HU were calculated. The relationships of these breast adipose tissue parameters with tumor factors and RFS were assessed. TAT HU was significantly higher than CAT HU (p < 0.001). TAT HU, HU difference, and HU difference % showed significant correlations with T stage and estrogen receptor and progesterone receptor status (p < 0.05), whereas CAT HU had no significant relationships with tumor factors (p > 0.05). Patients with high TAT HU, HU difference, and HU difference % had significantly worse RFS than those with low values (p < 0.001). In multivariate analysis, TAT HU and HU difference % were significantly associated with RFS after adjusting for clinico-pathologic factors (p < 0.05). CT-attenuation of tumor-adjacent breast adipose tissue was significantly associated with RFS in patients with breast cancer. The findings seem to support the close contact between breast cancer cells and tumor-adjacent adipocytes observed with imaging studies.

Distribution of Organohalogen and Synthetic Musk Compounds in Breast Adipose Tissue of Breast Cancer Patients in Ulster County, New York, USA

2019 ◽  
Vol 77 (1) ◽  
pp. 68-78
Author(s):  
Adela Jing Li ◽  
Sheldon M. Feldman ◽  
Richard K. McNally ◽  
Kurunthachalam Kannan
Keyword(s):  
Breast Cancer ◽  
New York ◽  
Adipose Tissue ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Synthetic Musk ◽  
Breast Adipose Tissue ◽  
Breast Adipose

Retinoids, Carotenoids, and Tocopherols in Breast Adipose Tissue and Serum of Benign Breast Disease and Breast Cancer Patients

2012 ◽  
Vol 64 (7) ◽  
pp. 956-963 ◽  
Author(s):  
Eugene Shim ◽  
Kyung-Jin Yeum ◽  
Guangwen Tang ◽  
Sei Hyun Ahn ◽  
Jinah Hwang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Adipose Tissue ◽  
Cancer Patients ◽  
Benign Breast Disease ◽  
Breast Disease ◽  
Breast Cancer Patients ◽  
Breast Adipose Tissue ◽  
Breast Adipose

scholarly journals Crown-like structures in breast adipose tissue of breast cancer patients: associations with CD68 expression, obesity, metabolic factors and prognosis

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Martin C. Chang ◽  
Zohreh Eslami ◽  
Marguerite Ennis ◽  
Pamela J. Goodwin
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Adipose Tissue ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
C Reactive Protein ◽  
Metabolic Factors ◽  
Reactive Protein ◽  
Breast Adipose Tissue ◽  
Disease Free

AbstractCrown-like structures of the breast (CLS-B), defined by the clustering of macrophages (identified using CD68 immunohistochemical staining) to surround a dying adipocyte, are a sign of adipose-tissue inflammation. In human cohorts, CLS-B positively correlates with older age, obesity, dyslipidemia and higher levels of glucose, insulin, C-reactive protein and IL-6. In an existing cohort of early-stage breast cancer patients, CLS-B were identified using H&E stained histologic sections (hCLS-B), and by CD68 immunohistochemistry (CD68 + CLS-B). We examined associations of H&E and CD68-detected CLS-B with clinicopathologic features using χ2 tests, with metabolic factors using Wilcoxon rank sum tests and with disease free and overall survival using Cox regression models. hCLS-B were detected in 59 of 163 patients with slides (36.2%) and CD68 + CLS-B in 37 of 119 patients with paraffin blocks (31.1%). hCLS-B were positively correlated with higher weight (p = 0.003), BMI (p = 0.0008) and C-reactive protein (p = 0.045). CD68 + CLS-B were positively correlated with higher weight (p = 0.006), BMI p = 0.001), leptin (p = 0.034), insulin (p = 0.008) and Homeostasis Model Assessment (p = 0.027). CD68 + CLS-B were associated with poor distant disease-free with a hazard ratio (HR) of 2.81, 95% confidence interval (CI) 1.20–6.57, and overall survival with HR 3.97 (1.66–9.48), while hCLS-B were not associated with either: HR for distant recurrence 0.59 (0.26–1.30); HR for death 1.04 (0.50–2.16). The presence of hCLS-B and of CD68 + CLS-B were associated with obesity; CD68 + CLS-B were associated with insulin resistance and adverse prognosis. Similar patterns were not seen for hCLS-B. Research is needed to understand the biologic basis for these differences.

scholarly journals Local Biomarkers Involved in the Interplay between Obesity and Breast Cancer

Cancers ◽  
2021 ◽  
Vol 13 (24) ◽  
pp. 6286
Author(s):  
Jonas Busk Holm ◽  
Ann H. Rosendahl ◽  
Signe Borgquist
Keyword(s):  
Breast Cancer ◽  
Adipose Tissue ◽  
Current Knowledge ◽  
Local Environment ◽  
Aromatase Activity ◽  
Breast Cancer Patients ◽  
Increased Risk ◽  
Breast Adipose Tissue ◽  
Breast Adipose ◽  
Inflammatory State

Obesity is associated with an increased risk of breast cancer, which is the most common cancer in women worldwide (excluding non-melanoma skin cancer). Furthermore, breast cancer patients with obesity have an impaired prognosis. Adipose tissue is abundant in the breast. Therefore, breast cancer develops in an adipose-rich environment. During obesity, changes in the local environment in the breast occur which are associated with breast cancer. A shift towards a pro-inflammatory state is seen, resulting in altered levels of cytokines and immune cells. Levels of adipokines, such as leptin, adiponectin, and resistin, are changed. Aromatase activity rises, resulting in higher levels of potent estrogen in the breast. Lastly, remodeling of the extracellular matrix takes place. In this review, we address the current knowledge on the changes in the breast adipose tissue in obesity associated with breast cancer initiation and progression. We aim to identify obesity-associated biomarkers in the breast involved in the interplay between obesity and breast cancer. Hereby, we can improve identification of women with obesity with an increased risk of breast cancer and an impaired prognosis. Studies investigating mammary adipocytes and breast adipose tissue in women with obesity versus women without obesity are, however, sparse and further research is needed.

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