A case of fatal intoxication with sodium azide

This review summarizes the synthesis, reactions, and biological activities of tetrazolo[1,5-a]quinoline derivatives. These derivatives were synthesized by several methods such as i) from the reaction of 2-chloroquinoline with sodium azide ii) from diazotization 2-hydrazinylquinoline derivatives, and iii) from intramolecular cyclocondensation of 2-azidoarylidenes. Also, the chemical reactions and pharmacological activities of some tetrazoloquinolines such as tetrazolo[1,5-a]quinoline-4-carbaldehyde, 5-chlorotetrazolo[ 1,5-a]quinoline, 4-(chloromethyl)tetrazolo[1,5-a]quinoline, tetrazolo[1,5- a]quinoline-4-carboxylic acid, and 5-azidotetrazolo[1,5-a]quinoline were discussed.

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The preparation of 3-amino-3-deoxy-1,2-O-isopropylidene-α-L-erythrofuranose, 3-amino-3-deoxy-1,2-O-isopropylidene-β-D-threofuranose and their derivatives

Collection of Czechoslovak Chemical Communications ◽

10.1135/cccc19803378 ◽

1980 ◽

Vol 45 (12) ◽

pp. 3378-3390 ◽

Cited By ~ 3

Author(s):

Jiří Jarý ◽

Milena Masojídková ◽

Ivan Kozák ◽

Miroslav Marek ◽

Jan Staněk

Keyword(s):

Nucleophilic Substitution ◽

Sodium Azide ◽

Sodium Benzoate ◽

Nmr Spectra ◽

Subsequent Reduction ◽

H Nmr ◽

Amino Derivatives

The title amino derivatives VI and XIV were prepared by nucleophilic substitution of p-toluenesulfonyl derivatives II and XVII with sodium azide or hydrazine and subsequent reduction. Nucleophilic substitution of compounds II and XVII with sodium benzoate was also investigated. The 1H NMR spectra of the substances prepared are discussed.

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Effect of combined doses of gamma ray and sodium azide (mutagenic agents) on the morphological traits of some varieties of okra (Abelmoschus esculentus)

African Journal of Agricultural Research ◽

10.5897/ajar2016.11085 ◽

2016 ◽

Vol 11 (32) ◽

pp. 2968-2973 ◽

Cited By ~ 1

Author(s):

Hassana Maryam Ati ◽

Abu Kasimu Adamu

Keyword(s):

Sodium Azide ◽

Morphological Traits ◽

Gamma Ray ◽

Abelmoschus Esculentus

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The reaction of methyl 5-thio-3-O-toluene-p-sulfonyl-α-d-glucopyranoside and its triacetate with sodium azide

Carbohydrate Research ◽

10.1016/0008-6215(93)80043-e ◽

1993 ◽

Vol 242 ◽

pp. 287-290 ◽

Cited By ~ 5

Author(s):

Najim A. Al-Masoudi ◽

Wolfgang Pfleiderer

Keyword(s):

Sodium Azide

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Comparison of Ozonation and Electro-Fenton Processes for Sodium Azide Removal in Medical Laboratory Wastewater by Using Central Composite Design

Separation Science and Technology ◽

10.1080/01496395.2020.1861017 ◽

2020 ◽

pp. 1-16

Author(s):

Irfan Basturk ◽

Selda Murat-Hocaoglu ◽

Gamze Varank ◽

Senem Yazici-Guvenc

Keyword(s):

Central Composite Design ◽

Sodium Azide ◽

Medical Laboratory ◽

Central Composite

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An efficient and practical chemo-enzymatic route to (3R,3aR,6R,6aR)-hexahydrofuro[3,2-b]furan-6-amino-3-ol (6-aminoisomannide) from renewable sources

SynOpen ◽

10.1055/a-1532-5825 ◽

2021 ◽

Author(s):

Valerio Zullo ◽

Antonella Petri ◽

Anna Iuliano

Keyword(s):

Hydroxy Group ◽

Sodium Azide ◽

Hydroxyl Group ◽

Azido Group ◽

One Pot ◽

Renewable Sources ◽

Nucleophilic Displacement ◽

Trifluoromethanesulfonic Anhydride ◽

Enzymatic Route

The synthesis of 6-aminoisomannide is easily achieved starting from the renewable, inexpensive and commercially available isosorbide, in 66% overall yield. A biocatalysed highly regioselective acetylation of the 3-endo hydroxyl group of isosorbide was followed by the stereospecific interconversion of the 6-exo hydroxyl group into azido group, through reaction with trifluoromethanesulfonic anhydride followed by nucleophilic displacement of the triflate group by sodium azide. Finally, reduction of the azido group and deacetylation of the 3-hydroxy group were performed one pot by using LiAlH4.

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Mechanistic understanding of the Cu(i)-catalyzed domino reaction constructing 1-aryl-1,2,3-triazole from electron-rich aryl bromide, alkyne, and sodium azide: a DFT study

Catalysis Science & Technology ◽

10.1039/d1cy00123j ◽

2021 ◽

Author(s):

Hanlin Gan ◽

Liang Peng ◽

Feng Long Gu

Keyword(s):

Density Functional Theory ◽

Dft Calculations ◽

Sodium Azide ◽

Density Functional ◽

Dft Study ◽

Domino Reaction ◽

Aryl Bromide ◽

Functional Theory ◽

Mechanistic Understanding

The mechanism of the Cu(i)-catalyzed domino reaction furnishing 1-aryl-1,2,3-triazole assisted by CuI and 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) is explored with density functional theory (DFT) calculations.

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Suicide by intoxication with iron (III) chloride

Forensic Toxicology ◽

10.1007/s11419-021-00579-6 ◽

2021 ◽

Author(s):

Sławomir Majdanik ◽

Barbara Potocka-Banaś ◽

Sebastian Glowinski ◽

Krzysztof Borowiak

Keyword(s):

Prussian Blue ◽

Chloride Ions ◽

Iron Chloride ◽

Histopathological Analysis ◽

Fatal Intoxication ◽

Internal Organs ◽

Specific Staining ◽

Iron Supplements ◽

Staining Protocol ◽

Hematoxylin And Eosin

Abstract Purpose Cases of iron intoxication are not very often encountered in toxicology practice, and most of those reported concern accidental intoxications with iron supplements in young children. The paper presents a rare case of a suicide by intoxication in an adult woman who ingested a solution of iron (III) chloride. Methods A forensic was at the Department of Forensic Medicine, PMU in Szczecin. Toxicology tests of blood sampled from the deceased were performed using a 644 CIBA CORNING ion selective analyzer and proprietary reagent kits. Histopathological was with the use of the standard staining protocol (hematoxylin and eosin) and staining specific for iron (Prussian blue). Results Autopsy revealed a distinct yellow discolouration and thrombotic necrosis of the oral mucosa and almost the whole gastrointestinal tract, as well as similar changes in the adjacent internal organs. Considerably high levels of iron and chloride ions were detected in specimens of internal organs preserved during autopsy. Histopathological analysis performed with the use of staining specific for iron (Prussian blue) also confirmed the presence of iron in the examined tissues, especially in the intestines and liver. Conclusions Considering the above findings, it was concluded in the forensic report that the death of the woman was caused by the ingestion of iron chloride. The reported case of fatal intoxication is one of the few described in the literature, and its course implies that in the case of initially diagnosed intoxication with corrosive compounds, the possibility of using metal-containing poison should also be considered in the differential diagnosis. In addition to routine toxicological tests performed in fatal cases we also draw attention to the possibility of using specific staining protocols for microscopic specimens.

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