Detection of optic nerve lesions in optic neuritis using frequency-selective fat-saturation sequences

D. H. Miller; D. G. Mac Manus; P. A. Bartlett; R. Kapoor; S. P. Morrissey; I. F. Moseley

doi:10.1007/bf00593976

Retrobulbar optic neuritis due to diseases of the posterior sinuses

Kazan medical journal ◽

10.17816/kazmj77430 ◽

1927 ◽

Vol 23 (9) ◽

pp. 973-973

Author(s):

N. A. Khristianov

Keyword(s):

Optic Nerve ◽

Optic Neuritis ◽

Circulatory System ◽

Nerve Lesions ◽

Retrobulbar Optic Neuritis ◽

Anatomical Connection

Close anatomical connection between the optic nerve and the posterior nasal appendages and the commonality of their circulatory system explain optic nerve lesions in purulent and catarrhal processes in the posterior sinuses. N.A. Khristianov describes a case of left-sided retrobulbar optic neuritis cured by opening the middle and posterior lattices of the same side, affected by chronic catarrh.

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DETECTION OF OPTIC NERVE LESIONS IN OPTIC NEURITIS WITH MAGNETIC RESONANCE IMAGING

The Lancet ◽

10.1016/s0140-6736(86)91517-5 ◽

1986 ◽

Vol 327 (8496) ◽

pp. 1490-1491 ◽

Cited By ~ 22

Author(s):

D.H Miller ◽

G Johnson ◽

W.I Mcdonald ◽

D Macmanus ◽

E.P.G.H Duboulay ◽

...

Keyword(s):

Magnetic Resonance Imaging ◽

Optic Nerve ◽

Magnetic Resonance ◽

Optic Neuritis ◽

Resonance Imaging ◽

Nerve Lesions

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Acute optic nerve lesions in first-ever NMOSD-related optic neuritis using conventional brain MRI: A Latin American multicenter study

Multiple Sclerosis and Related Disorders ◽

10.1016/j.msard.2020.102558 ◽

2020 ◽

Vol 46 ◽

pp. 102558

Author(s):

Edgar Carnero Contentti ◽

Guillermo Delgado-García ◽

Pablo A. López ◽

Juan Criniti ◽

Juan Pablo Pettinicchi ◽

...

Keyword(s):

Optic Nerve ◽

Optic Neuritis ◽

Latin American ◽

Multicenter Study ◽

Brain Mri ◽

Nerve Lesions

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Quantitative Contrast-Enhanced MR Imaging of the Optic Nerve

Acta Radiologica ◽

10.1177/028418519403500604 ◽

1994 ◽

Vol 35 (6) ◽

pp. 526-531 ◽

Cited By ~ 1

Author(s):

J. H. Simon ◽

D. Rubinstein ◽

M. Brown ◽

W. Yuh ◽

M. Birch-Iensen ◽

...

Keyword(s):

Optic Nerve ◽

Mr Imaging ◽

Optic Neuritis ◽

Signal Intensity ◽

Pulse Sequence ◽

Spin Echo ◽

Fat Suppression ◽

Significant Enhancement ◽

Contrast Enhanced ◽

Frequency Selective

During the acute stages of optic neuritis damage to the blood-optic nerve barrier can be detected using i.v. paramagnetic contrast-enhanced MR imaging. Quantification of the enhancement pattern of the optic nerve, intraorbital fat and muscle was determined in 15 normal subjects using 3 fat-suppression MR imaging methods: T1-weighted spin-echo and spoiled gradient-echo sequences preceded by a fat-frequency selective pulse (FATSAT + SE and FATSAT + SPGR, respectively) and a pulse sequence combining CHOPPER fat suppression with a fat-frequency selective preparation pulse (HYBRID). Pre- and postcontrast-enhanced studies were acquired for FATSAT + SE and FATSAT + SPGR. There was no significant enhancement of the optic nerve by either method (mean increase of 0.96% and 5.3%, respectively), while there was significant enhancement in muscle (mean 118.2% and 108.2%), respectively; p < 0.005) and fat (mean increase of 13% and 37%, respectively; p < 0.05). Postcontrast optic nerve/muscle signal intensity ratios (mean, SD) were 0.51 (0.07), 0.58 (0.05) and 0.75 (0.05) for FATSAT + SE, FATSAT + SPGR and HYBRID, respectively. These results suggest a practical methodology and range of values for normal signal intensity increases and ratios of tissue signal that can be used as objective measures of optic neuritis for natural history studies and treatment trials.

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Asymptomatic optic nerve lesions

Neurology ◽

10.1212/wnl.0000000000009504 ◽

2020 ◽

Vol 94 (23) ◽

pp. e2468-e2478 ◽

Cited By ~ 5

Author(s):

Jean-Baptiste Davion ◽

Renaud Lopes ◽

Élodie Drumez ◽

Julien Labreuche ◽

Nawal Hadhoum ◽

...

Keyword(s):

Multiple Sclerosis ◽

Visual Acuity ◽

Optic Nerve ◽

Optic Neuritis ◽

Brain Mri ◽

Lesion Length ◽

Nerve Lesion ◽

Inner Plexiform Layer ◽

Nerve Lesions ◽

Optic Nerve Lesion

ObjectiveTo evaluate the frequency of asymptomatic optic nerve lesions and their role in the asymptomatic retinal neuroaxonal loss observed in multiple sclerosis (MS).MethodsWe included patients with remitting-relapsing MS in the VWIMS study (Analysis of Neurodegenerative Process Within Visual Ways In Multiple Sclerosis) (ClinicalTrials.gov Identifier: 03656055). Included patients underwent optical coherence tomography (OCT), optic nerve and brain MRI, and low-contrast visual acuity measurement. In eyes of patients with MS without optic neuritis (MS-NON), an optic nerve lesion on MRI (3D double inversion recovery [DIR] sequence) was considered as an asymptomatic lesion. We considered the following OCT/MRI measures: peripapillary retinal nerve fiber layer thickness, macular ganglion cell + inner plexiform layer (mGCIPL) volumes, optic nerve lesion length, T2 lesion burden, and fractional anisotropy within optic radiations.ResultsAn optic nerve lesion was detected in half of MS-NON eyes. Compared to optic nerves without any lesion and independently of the optic radiation lesions, the asymptomatic lesions were associated with thinner inner retinal layers (p < 0.0001) and a lower contrast visual acuity (p ≤ 0.003). Within eyes with asymptomatic optic nerve lesions, optic nerve lesion length was the only MRI measure significantly associated with retinal neuroaxonal loss (p < 0.03). Intereye mGCIPL thickness difference (IETD) was lower in patients with bilateral optic nerve DIR hypersignal compared to patients with unilateral hypersignal (p = 0.0317). For the diagnosis of history of optic neuritis, sensitivity of 3D DIR and of mGCIPL IETD were 84.9% and 63.5%, respectively.ConclusionsAsymptomatic optic nerve lesions are an underestimated and preponderant cause of retinal neuroaxonal loss in MS. 3D DIR sequence may be more sensitive than IETD measured by OCT for the detection of optic nerve lesions.

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Availability of frequency-selective fat-Saturation pulse (fat-Sat) MRI in childhood optic neuritis

Pediatric Neurology ◽

10.1016/0887-8994(95)00254-5 ◽

1996 ◽

Vol 14 (1) ◽

pp. 64-65 ◽

Cited By ~ 2

Author(s):

Jun-ichi Takanashi ◽

Katsuo Sugita ◽

Junko Matsubayashi ◽

Kimi Sato ◽

Hiroo Niimi

Keyword(s):

Optic Neuritis ◽

Saturation Pulse ◽

Fat Saturation ◽

Frequency Selective

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Remyelination of optic nerve lesions: spatial and temporal factors

Multiple Sclerosis Journal ◽

10.1177/1352458510371408 ◽

2010 ◽

Vol 16 (7) ◽

pp. 786-795 ◽

Cited By ~ 27

Author(s):

Alexandr Klistorner ◽

Hemamalini Arvind ◽

Raymond Garrick ◽

Con Yiannikas ◽

Mark Paine ◽

...

Keyword(s):

Optic Nerve ◽

Optic Neuritis ◽

Evoked Potentials ◽

Visual Evoked Potentials ◽

In Vivo Model ◽

Nerve Lesions ◽

Multifocal Visual Evoked Potentials ◽

Average Latency ◽

Visual Evoked

Optic neuritis provides an in vivo model to study demyelination. The effects of myelin loss and recovery can be measured by the latency of the multifocal visual evoked potentials. We investigated whether the extent of initial inflammatory demyelination in optic neuritis correlates with the remyelinating capacity of the optic nerve. Forty subjects with acute unilateral optic neuritis and good visual recovery underwent multifocal visual evoked potentials testing at 1, 3, 6 and 12 months. Average latency changes were analyzed. Extensive latency delay at baseline significantly improved over time with rate of recovery slowed down after 6 months. Magnitude of latency recovery was independent of initial latency delay. Latency recovery ranged from 7 to 17 ms across the whole patient cohort (average = 11.3 (3.1) ms) despite the fact that in a number of cases the baseline latency delay was more than 35—40 ms. Optic nerve lesions tend to remyelinate at a particular rate irrespective of the size of the initial demyelinated zone with smaller lesions accomplishing recovery more completely. The extent of the initial inflammatory demyelination is probably the single most important factor determining completeness of remyelination. The time period favorable to remyelination is likely to be within the first 6 months after the attack.

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Management of Optic Neuritis in Ayurveda - A Special Case Report

Journal of Ayurveda and Integrated Medical Sciences (JAIMS) ◽

10.21760/jaims.v3i5.13847 ◽

2018 ◽

Vol 3 (5) ◽

Author(s):

Dr. Harsha S. ◽

Dr. Mamatha KV.

Keyword(s):

Optic Nerve ◽

Optic Neuritis ◽

Visual Information ◽

Vision Loss ◽

Specific Treatment ◽

Interesting Case ◽

Treatment Modalities ◽

Further Development ◽

Special Case

The optic nerve carries visual information from your eye to your brain. Optic neuritis is when your optic nerve becomes inflamed. Optic neuritis can flare up suddenly from an infection or nerve disease. The inflammation usually causes temporary vision loss that typically happens in only one eye. Those with Optic neuritis sometimes experience pain. As you recover and the inflammation goes away, your vision will likely return. There are no direct references in our classics regarding optic neuritis but can be contemplated as a condition by name Parimlayi Timira. The specific management as such is not cited but a transcendence approach can be done with adopting the treatment which has the ability to pacify the already occurred pathology and prevent the further development of the disease. One such interesting case study on Optic neuritis is elaborated here where in specific treatment modalities (Shodana, Shamana and Kriyakalpas) played role in pacifying the condition.

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