Immunohistological analysis of tumour infiltrating lymphocytes in seminoma using monoclonal antibodies

1992 ◽  
Vol 421 (5) ◽  
pp. 409-413 ◽  
Author(s):  
Takashi Nakanoma ◽  
Kaoru Nakamura ◽  
Nobuhiro Deguchi ◽  
Junichiro Fujimoto ◽  
Hiroshi Tazaki ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
Tumour Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes ◽  
Immunohistological Analysis

Activation and expansion of tumour-infiltrating lymphocytes by anti-CD3 and anti-CD28 monoclonal antibodies

1990 ◽  
Vol 32 (4) ◽  
pp. 245-250 ◽  
Author(s):  
Erik W. P. Nijhuis ◽  
Elly v/d Wiel-van Kemenade ◽  
Carl G. Figdor ◽  
René A. W. van Lier
Keyword(s):  
Monoclonal Antibodies ◽  
Tumour Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes

scholarly journals The relationship between CD204 M2-polarized tumour-associated macrophages (TAMs), tumour-infiltrating lymphocytes (TILs), and microglial activation in glioblastoma microenvironment: a novel immune checkpoint receptor target

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Maher Kurdi ◽  
Badrah Alghamdi ◽  
Nadeem Shafique Butt ◽  
Saleh Baeesa
Keyword(s):  
Microglial Activation ◽  
Inverse Correlation ◽  
Idh1 Mutation ◽  
High Expression ◽  
Kaplan Meier ◽  
Significant Difference ◽  
Tumour Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes ◽  
The Relationship ◽  
Low Expression

Abstract Background Tumour associated macrophages (TAMs) and tumour infiltrating lymphocytes (TILs) are considered dominant cells in glioblastoma microenvironment. Aim The purpose of this study was to assess the expression of CD204+ M2-polarized TAMs in glioblastomas and their relationship with CD4+TILs, Iba+microglia, and IDH1 mutation. We also exploreed the prognostic value of these markers on the recurrence-free interval (RFI). Methods The expressions of CD204+TAMs, CD4+TILs, and Iba1+microglia were quantitively assessed in 45 glioblastomas using immunohistochemistry. Kaplan–Meier analysis and Cox hazards were used to examine the relationship between these factors. Results CD204+TAMs were highly expressed in 32 tumours (71%) and the remaining 13 tumours (29%) had reduced expression. CD4+TILs were highly expressed in 10 cases (22%) and 35 cases (77.8%) had low expression. There was an inverse correlation between CD204+TAMs and CD4+TILs, in which 85% of tumours had a high expression of CD204+TAMs and a low expression of CD4+TILs. Nevertheless, there was no significant difference in IDH1 mutation status between the two groups (p = 0.779). There was a significant difference in Iba1+microglial activation between IDH1mutant and IDH1wildtype groups (p = 0.031). For cases with a high expression of CD204+TAMs and a low expression of CD4+TILs, there was a significant difference in RFI after treatment with chemoradiotherapy or radiotherapy (p = 0.030). Conclusion Glioblastoma with a dense CD204+TAMs and few CD4+TILs is associated with IDH1wildtype. These findings suggest that TAMs masks tumour cell and suppress T-cell tumoricidal functions via immunomodulatory mechanisms. Blockade of the CD204-TAM receptor may prevent this mechanism and allow the evolution of TILs.

Tumour-infiltrating lymphocytes in colorectal cancer with microsatellite instability are activated and cytotoxic

2004 ◽  
Vol 91 (4) ◽  
pp. 469-475 ◽  
Author(s):  
S. M. Phillips ◽  
A. Banerjea ◽  
R. Feakins ◽  
S. R. Li ◽  
S. A. Bustin ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Instability ◽  
Tumour Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes

Prognostic value of stromal tumour infiltrating lymphocytes and programmed cell death-ligand 1 expression in breast cancer

2017 ◽  
Vol 70 (10) ◽  
pp. 860-867 ◽  
Author(s):  
António Polónia ◽  
Regina Pinto ◽  
Jorge F Cameselle-Teijeiro ◽  
Fernando C Schmitt ◽  
Joana Paredes
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Prognostic Value ◽  
Stromal Tumour ◽  
Tumour Infiltrating Lymphocytes ◽  
Infiltrating Lymphocytes
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