Еarly diagnosis of multiple sclerosis: experience with the use of class G oligoclonal immunoglobulin

2021 ◽  
Vol 26 (3) ◽  
pp. 34-39
Author(s):  
Z. A. Goncharova ◽  
Y. Y. Pogrebnova ◽  
N. M. Yarosh ◽  
S. M.M. Sehweil

The article presents the literature review and our experience in early diagnosis of multiple sclerosis based on the updated McDonald criteria of 2017. The study included 256 patients with clinic symptoms of probable idiopathic infl ammatory demyelinating disease, including rare and atypical forms of demyelination. As a result of the study the sensitivity and specifi city of the determination of oligoclonal immunoglobulin G in the population of Rostov-on-Don was described for the fi rst time, including dependence of the duration of the disease. The relationship of clinical and MRI features of the fi rst attack of the disease with the probability of determining oligoclonal IgG in the cerebrospinal fl uid is refl ected

2012 ◽  
Vol 34 (3) ◽  
pp. 169-184 ◽  
Author(s):  
Hoang Thi Bich Ngoc

Vertical axis wind turbine technology has been applied last years, very long after horizontal axis wind turbine technology. Aerodynamic problems of vertical axis wind machines are discussible. An important problem is the determination of the incidence law in the interaction between wind and rotor blades. The focus of the work is to establish equations of the incidence depending on the blade azimuth, and to solve them. From these results, aerodynamic torques and power can be calculated. The incidence angle is a parameter of velocity triangle, and both the factors depend not only on the blade azimuth but also on the ratio of rotational speed and horizontal speed. The built computational program allows theoretically selecting the relationship of geometric parameters of wind turbine in accordance with requirements on power, wind speed and installation conditions.


1986 ◽  
Vol 14 (4) ◽  
pp. 201-218 ◽  
Author(s):  
A. G. Veith

Abstract This four-part series of papers addresses the problem of systematic determination of the influence of several tire factors on tire treadwear. Both the main effect of each factor and some of their interactive effects are included. The program was also structured to evaluate the influence of some external-to-tire conditions on the relationship of tire factors to treadwear. Part I describes the experimental design used to evaluate the effects on treadwear of generic tire type, aspect ratio, tread pattern (groove or void level), type of pattern (straight rib or block), and tread compound. Construction procedures and precautions used to obtain a valid and functional test method are included. Two guiding principles to be used in the data analyses of Parts II and III are discussed. These are the fractional groove and void concept, to characterize tread pattern geometry, and a demonstration of the equivalence of wear rate for identical compounds on whole tread or multi-section tread tires.


1970 ◽  
Vol 5 (3) ◽  
pp. 80-96
Author(s):  
Mayara Motta Melo ◽  
Clarissa Santos de Carvalho Ribeiro

RESUMOA incidência do câncer de pele vem aumentando a cada ano. Sabe-se que entre outros fatores, a radiação solar é a principal responsável pelo desenvolvimento dessa patologia. A prevenção, feita através da fotoproteção, teria grande impacto nesse cenário. No entanto, as orientações sobre como se proteger dos malefícios do sol devem ser coerentes com a incidência solar da região, os hábitos da população e o fototipo da pele. Os conceitos sobre fotoproteção foram definidos por entidades européias e norte americanas e não devem ser reproduzidos para o Brasil de forma aleatória, pois a incidência solar no Brasil é muito maior, a população tem fototipos diferentes e o hábito de se expor ao sol é muito mais frequente. Portanto, faz-se necessário elaborar conceitos próprios para o Brasil e conscientizar a população sobre os perigos da radiação solar para que a incidência do câncer de pele reduza definitivamente. Essa revisão visa mostrar a relação da radiação solar no Brasil com a pele dos brasileiros e evidenciar a importância da fotoproteção para essa população. Para isso foi feito um levantamento de artigos originais, revisões de literatura, consensos brasileiros e internacionais e livros de dermatologia.Palavras-chave: Fotoproteção, Câncer de pele, Exposição solar, Radiação ultravioleta, Vitamina D. ABSTRACTThe incidence of skin cancer is increasing every year. It is known that among other factors, solar radiation is the main responsible for the development of this pathology. Prevention, made by photoprotection, would have great impact in this scenario. However, the guidelines on how to protect themselves from the sun's harmful effects should be consistent with the sunlight of the region, the habits of the population and the phototype skin. The concepts of photoprotection were defined by European and North American entities and should not be played for Brazil at random, as the solar incidence in Brazil is much higher, people have different skin types and the habit of sun exposure is much more frequent. Therefore, it is necessary to draw up own concepts for Brazil and raise awareness about the dangers of solar radiation, so that the incidence of skin cancer can be definitely reduced. This review aims to show the relationship of solar radiation in Brazil with the skin of Brazilian and to highlight the importance of sun protection for this population. With this purpose, it was  made a survey of original articles, literature reviews , Brazilian and international consensus and dermatology books.Keywords: Photoprotection, Skin cancer, Sun exposure, Ultraviolet radiation, D vitamin.


2016 ◽  
Vol 11 (3) ◽  
pp. 802-810 ◽  
Author(s):  
Nitin Yashwant Patil ◽  
Ravi M. Warkhedkar

Purpose In the past decade, much has been written about knowledge management (KM) in the manufacturing; however, less attention has been paid to the Indian automobile ancillary industries located in Chinchwad, Pune. It is suitable to find out the relationship of the factors of the study. It helps in identifying the hierarchy of factors to be taken, and interlinking of production department with KM improves the productivity of the industries. Categorization of these principles based on their driving power (principles which hold other principles) and dependence (principles which are dependent on other principles) has also been examined for KM implementation to study the driving power and dependence power of these principles. This paper aims to determine the roadmap of KM implementation and categorize KM principles based on their driving power for manufacturing industries with the use of the interpretive structural modeling (ISM)-based model. The results indicate that the principles possessing higher driving power, such as KM, inventory control, quality control, productivity and scheduling and their interlinking. The major contribution of this research lies in the development of contextual relationship among various identified factors of KM and determination of their driving and dependence power through a single systemic framework. Design/methodology/approach In this paper, author find out the suitability ISM for Indian Automobile industries to find the relation among the variables. Findings ISM model has been developed for the hierarchy of the identified KM. As ISM model results a hypothetical hierarchy which needs a proper quantitative analysis to evaluate their percentage effectiveness in the hierarchy. Research limitations/implications It is applied to automobile industries with limited number of variables that will show the dependence variable and driving variables and their interrelations. It can be applied other fields to fine the relationship of variables. Practical implications The ISM may be used in supply chain management and total quality management to find interlinking between the variables. Originality/value The limited data collected from Pimpri Chinchwad industrial area of Pune from Maharashtra state (India).


2015 ◽  
Vol 60 (11) ◽  
pp. 1-15
Author(s):  
Olga Leszczyńska-Luberek

The author presents the importance of the new European System of National and Regional Accounts (ESA 2010) for statistics of the general government sector. She pays particular attention to the development of data for the excessive deficit procedure. The article explains the methodological changes made to the studies in this field parallel to the ESA 2010. It discusses, among others, issues related to defining the deficit and debt of the general government, as well as the determination of a new way registering transfer of liabilities of pension schemes. It also presents the impact of new methodological guidelines for the relationship of deficit and debt to GDP in the Member States of the European Union.


2018 ◽  
Vol 12 (3) ◽  
pp. 220-232 ◽  
Author(s):  
Elizabeth Karol ◽  
Dianne Smith

Aim:The objective of this article is to identify and analyze what is known about characteristics in and around the home that support well-being for those with cognitive impairment. This could provide direction for designers of homes in general, but specifically for designers trying to meet the needs of people with cognitive impairment.Background:It has been established that there is a relationship between psychological well-being and a person’s environment. Research also shows that particular design aspects can reduce the impact of cognitive impairment. However, there is limited design expertise in the Australian housing market to create supportive spaces which will help to reduce the impact of the disability for those with cognitive impairment.Method:A literature review was carried out to determine the extent and details of what is known about the relationship of home design and its impact on emotional, psychological, or social well-being for people with cognitive impairment.Conclusions:The study indicates that researchers in various disciplines understand that pragmatic design inputs such as thermal comfort and adequate lighting are important for people with cognitive impairment. In addition, some researchers have shown or surmise that there are other “intangible” designer-controlled elements that have beneficial impacts on people with cognitive impairment. Details of these intangible elements are sparse, and how much they might improve the quality of life for a person with cognitive impairment is not well understood. Further research is required to meet a growing need.


2021 ◽  
Vol 12 (1) ◽  
pp. 113-125
Author(s):  
D.A. Krasilo ◽  
T.A. Krassilo ◽  
A.N. Zalipaeva

Objectives. Studying the relationship of autonomy and attachment in relationships with parents with real self-determination in students. Background. The growing world globalization, intercultural contradictions, confrontation within society seriously complicate the path of self-determination of modern youth. At the same time, due to technical progress and digitalization of the communication and education environment, there are significant transformations in the interaction of people in almost all spheres, including in the family. Therefore, the question of studying the most important aspects in the relationship of young people with their parents for real self-determination is especially acute. Study design. The work studied the indicators of real self-determination, attachment to parents and autonomy among students. The presence of a relationship between these parameters was established by calculating the Spearman correlation coefficient. Participants. 60 college students aged 18 to 21. Measurements. Methodology “Scale of adult attachment for close relationships”; autonomy questionnaire (authors O.A. Karabanova and N.N. Poskrebysheva); questionnaire “ORS” (author D.A. Krasilo). Results. An inverse relationship of indicators of real self-determination of students with the level of intimacy and the level of anxiety (scales of attachment to parents) was established. A direct relationship was revealed between the indicators of real self-determination and the level of autonomy. Conclusions. Proximity and anxiety (components of attachment) have a significant inverse relationship with the level of real self-determination in students. There are no significant connections between reliability (a component of attachment) and real self-determination in the sample under study. Emotional autonomy, cognitive autonomy, behavioral autonomy, and value autonomy have significant positive correlations with the level of real self-determination in students.


2021 ◽  
Vol 21 (3-4) ◽  
pp. 83-88
Author(s):  
Anton I. Belkin

Review of the book Mind Games: towards understanding the nature of prejudice and conflict, or how to learn to live in peace by Terrence Webster-Doyle. Mind Games: To understand the roots of prejudice and how to learn live peacefully: a scientific and educational publication. T. Webster-Doyle. Samara Cultural Society Artifact-Cultural Diversity. Samara: Samara Scientific Center of the Russian Academy of Sciences; 2020. 55 p. Reviewer considers that T. Webster-Doyles book is a brilliant example of how conflicts can be resolved most effectively without theorized distraction. T. Webster-Doyles book is small in volume, but very significant in content. The author offers a real program for taming the conflicts and violence that fill the entire human history. Until now, there is a clear lack of research on the universal determinants of the emergence and dynamics of conflict. A paradoxical situation arises when methods of conflict resolution are studied and modified, despite the fact that its initial determinants are not accurately determined. The models of taming conflicts that are being replicated in the social sciences almost do not solve the very problem of overcoming violence in society. Note that T. Webster-Doyle defines her book as the most significant work of her life. The author proposes an original approach to the determination of the conflict and defines the ways of its resolution in direct relationship with the understanding of its determinants. Also, the advantage of the book is a good literary presentation of the material. T. Webster-Doyle views conflict as a phenomenon created by the human mind, which at the same time, in a paradox, is trying to solve a problem which it itself creates. This work is devoted to the study of the determinants of conflict, which are considered comprehensively in the relationship of biological and social determinants: as generated by genetically programmed brain programs and at the same time as a function of peoples perception of the world around them and each other. The author notes that the universal basis of biological programming is the general motivation the desire to survive. Consequently, this work presents a program for resolving the conflict based on a comprehensive consideration of the conflict as a sociobiological phenomenon, which is based on the conditioned thinking of a person (primordial biological protection of his brain). The advantage of the book is its versatility. The author does not just consider the problem of the conflict, its components, the parties to the conflict, conflict genes, the incident, etc. He is looking for an approach that allows you to take a fresh look at this problem and find ways to prevent and destroy the conflict.


Author(s):  
Ayu Kurniati ◽  
Enny Fitriahadi

IN 2013, the World Health Organization, released data in the form of Maternal Mortality Rate (MMR) worldwide, and the number reached 289,000 per 100, 000 live births, which 99% of cases occurred in developing countries. Research aims to discover the relationship of antenatal class towards mothers’ knowledge of the dangerous sign during pregnancy. The result showed that there is a relationship of antenatal class towards mothers’ knowledge of dangerous sign during pregnancy, From this result, the researcher concludes that antenatal class could increase mothers’ knowledge of dangerous sign during pregnancy and may decrease the complication risk during the childbirth.


Author(s):  
Rita de Cássia do Vale Caribé ◽  
Alejandra Aguilar Pinto ◽  
Fabiene Castelo Branco Diogenes

Estudo insere-se na área de estudo de usuários, relata os resultados de um survey, realizado no Distrito Federal (DF), Brasil, com o objetivo de identificar as necessidades e o uso de informação pelas mulheres, tendo utilizado uma amostra aleatória de 37 entrevistas estruturadas. Inclui breve revisão de literatura sobre estudos de usuários com o objetivo de identificar as necessidades e uso da informação por diferentes categorias de indivíduos; apresenta a evolução dos estudos de usuários em termos metodológicos e de abordagem quantitativa e qualitativa; e estudos relacionados à necessidade e uso de informação do gênero mulher. Nesta pesquisa foram identificados os graus de importância de alguns temas, as fontes e instrumentos que interessam à mulher do DF e a gradação de freqüência do uso, bem como, analisada a relação dessas fontes de preferência com o perfil de escolaridade, idade e renda.AbstractThis study may be considered an information user needs study. It reports results of a survey conducted in Distrito Federal (DF), Brazil. Its objective was identifying the information needs and use of women, and was used a random sample of 37 interviews structured. Includes brief literature review on user studies with the goal of identifying the needs and use of information by different individuals categories; shows the evolution of user studies of quantitative and qualitative methodology and approach; and the need and use of information from the woman gender studies. In this research the importance degrees of some topics, sources and instruments that are interested to the wife of DF and gradation of frequency of use were identified, were analyzed the relationship of these sources preferably with the profile of education, age and income.KeywordsUser information needs. User studies. Woman gender.AbstractThis study may be considered an information user needs study. It reports results of a survey conducted in Distrito Federal (DF), Brazil. Its objective was identifying the information needs and use of women, and was used a random sample of 37 interviews structured. Includes brief literature review on user studies with the goal of identifying the needs and use of information by different individuals categories; shows the evolution of user studies of quantitative and qualitative methodology and approach; and the need and use of information from the woman gender studies. In this research the importance degrees of some topics, sources and instruments that are interested to the wife of DF and gradation of frequency of use were identified, were analyzed the relationship of these sources preferably with the profile of education, age and income. Keywords User information needs. User studies. Woman gender.


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