New findings in the fatty acid composition of individual platelet phospholipids in man after dietary fish oil supplementation

Lipids ◽  
1987 ◽  
Vol 22 (10) ◽  
pp. 744-750 ◽  
Author(s):  
Trevor A. Mori ◽  
James P. Codde ◽  
Robert Vandongen ◽  
Lawrence J. Beilin
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Fish Oil ◽  
Acid Composition ◽  
New Findings ◽  
Dietary Fish ◽  
Fish Oil Supplementation

Effect of graded dietary fish oil supplementation on body composition and fillet fatty acid composition of pike (Esox luciusL.)

2012 ◽  
Vol 41 (1) ◽  
pp. 86-93 ◽  
Author(s):  
T. Molnár ◽  
B. Kucska ◽  
A. Szabó ◽  
J. Biró ◽  
M. Bercsényi ◽  
...  
Keyword(s):  
Body Composition ◽  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Fish Oil ◽  
Acid Composition ◽  
Dietary Fish ◽  
Fish Oil Supplementation

Dietary Fish Oil Alters Rat Milk Composition and Liver and Brain Fatty Acid Composition of Fetal and Neonatal Rats

1993 ◽  
Vol 123 (10) ◽  
pp. 1703-1708 ◽  
Author(s):  
Akie Yonekubo ◽  
Shyuji Honda ◽  
Mariko Okano ◽  
Kayoko Takahashi ◽  
Yoshiro Yamamoto
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Fish Oil ◽  
Acid Composition ◽  
Milk Composition ◽  
Neonatal Rats ◽  
Dietary Fish

Effects of dietary fish oil supplementation on the fatty acid composition of the human platelet membrane: demonstration of selectivity in the incorporation of eicosapentaenoic acid into membrane phospholipid pools

1985 ◽  
Vol 68 (4) ◽  
pp. 449-454 ◽  
Author(s):  
John H. Galloway ◽  
Ian J. Cartwright ◽  
Barrie E. Woodcock ◽  
Michael Greaves ◽  
R. Graham ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Platelet Aggregation ◽  
Eicosapentaenoic Acid ◽  
Fish Oil ◽  
Acid Composition ◽  
Platelet Membrane ◽  
Membrane Phospholipid ◽  
Membrane Phospholipids ◽  
Fish Oil Supplementation

1. The fatty acid composition of membrane phospholipids of stimulated and unstimulated platelets was studied in six normal volunteers given a daily dietary supplement of a fish oil rich in eicosapentaenoic acid (EPA) for 4 weeks. The supplement was equivalent to 1.8 g of EPA daily. Thromboxane synthesis and platelet aggregation responses to sodium arachidonate, thrombin and the ionophore A23187 were also investigated. 2. A marked increase in the relative EPA content of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) was noted after 2 and 4 weeks fish oil supplementation. However, there was no incorporation into phosphatidylinositol (PI) or phosphatidylserine (PS). The relative arachidonic acid (AA) content of PC and PE was significantly reduced at 2 and 4 weeks but that of PI and PS remained unchanged. Significant reductions in the relative linoleic acid content of total phospholipids, PC and PE were also noted. 3. Stimulation of platelets obtained after 4 weeks fish oil supplementation by thrombin and A23187 was associated with a marked reduction in the AA content of PI and a minor reduction in that of PE. There was no change in the relative proportions of EPA in PI, PS, PC or PE after stimulation. Throughout the study there were no significant changes in platelet aggregation responses or in platelet thromboxane production. 4. Our results indicate that the incorporation of EPA into the platelet membrane phospholipids is selective and that if PI is the major source of AA for platelet prostaglandin biosynthesis then the reported beneficial effects of EPA on haemostasis cannot be explained on the basis of its incorporation into and mobilization from the platelet membrane phospholipid pool.

scholarly journals The effect of increasing levels of dietary fish oil rich in eieosapentaenoic and docosahexaenoic acids on lymphocyte phospholipid fatty acid composition and cell-mediated immunity in the mouse

1993 ◽  
Vol 69 (2) ◽  
pp. 423-429 ◽  
Author(s):  
Alison Hinds ◽  
T. A. B. Sanders
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Fish Oil ◽  
Acid Composition ◽  
Phospholipid Fatty Acid ◽  
Cell Mediated Immunity ◽  
Phospholipid Fatty Acid Composition ◽  
Dietary Fish ◽  
Popliteal Lymph Node Assay ◽  
Docosahexaenoic Acids

The influence of increasing intakes of fish oil on spleen leucocyte phospholipid fatty acid composition and cell-mediated immunity was studied in the mouse using a popliteal lymph node assay technique. The immune response was suppressed by 160 g fish oil/kg diet, but not by lower doses. The proportion of 20: 5n-3 in spleen leucocyte phospholipid increased from 0.14 in the controls to 3.8, 7.2, 8.5 and 9.4% in the animals fed on 25, 50, 100 and 160 g fish oil/kg diet; the proportion of 22: 6n-3 increased from 5.1 in the controls to 12.1, 12.2, 12.8 and 12.9% respectively. It is concluded that moderate intakes of fish oil are not immunosuppressive.

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