Inhibitory effect of C-reactive protein on streptolysin O-mediated hemolytic activity. Comparison of conformational variants

1995 ◽  
Vol 119 (5) ◽  
pp. 488-491 ◽  
Author(s):  
P. G. Nazarov ◽  
L. K. Berestovaya
Keyword(s):  
Hemolytic Activity ◽  
Inhibitory Effect ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Streptolysin O ◽  
Activity Comparison

scholarly journals CORRELATION OF TOTAL COUNT (WBC), NEUTROPHIL COUNT AND CRP TEST AMONG FEBRILE PATIENTS IN NAVIMUMBAI.

2019 ◽  
Vol 3 (9) ◽  
Author(s):  
Dr. Sarita Shrivatstva ◽  
Dr. Narayana Kamath ◽  
Mrs. Ashwini Panchmahalkar
Keyword(s):  
Neutrophil Count ◽  
Bacterial Infections ◽  
Blood Count ◽  
Complete Blood Count ◽  
Malarial Parasite ◽  
Differential Count ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Streptolysin O ◽  
Febrile Condition

150 febrile patients included children (50), adult (50) and neonates (50) from outpatient departments and inpatients of private clinics and hospitals. Patients presented with fever and chills for more than 1 day to 3 days, throat infection, ear infection and cold and fever and only fever as the principal symptoms. After clinical examination all the patients were prescribed for Complete Blood Count (CBC) with differential count(DC) and C-reactive protein(CRP) tests, and in children below 14 years anti-Streptolysin O(ASO) tests ( 75) were prescribed. Patients treated with antibiotics previously two weeks before the study period were not included. Qualitative and quantitative tests were performed on all patients’ samples included in the study depending on the need/prescription by the physician or paediatrician. CBC, neutrophil count and CRP have been very useful indicators and significant in the diagnosis and treatment as well as follow-up of the febrile condition of the patients specially in patients suffering with bacterial infections. Even in patients with Dengue and malaria it gives a fair idea if there were leucocytosis or leukopenia, neutrophilia or neutropenia, thrombocytosis or thrombocytopenia. CBC: Complete blood count, DC: Differential count; MP: malarial parasite, CRP: C-reactive protein, ASO: Anti-Streptolysin O.

Surfactant strengthens the inhibitory effect of C-reactive protein on human lung macrophage cytokine release

2003 ◽  
Vol 284 (3) ◽  
pp. L466-L472 ◽  
Author(s):  
Cristina Casals ◽  
Javier Arias-Díaz ◽  
Fernando Valiño ◽  
Alejandra Sáenz ◽  
Cruz García ◽  
...  
Keyword(s):  
Proinflammatory Cytokines ◽  
Pulmonary Surfactant ◽  
Organ Donor ◽  
Inhibitory Effect ◽  
Multiple Organ ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Lung Macrophages ◽  
Tnf Α ◽  
Ifn Γ

In this study we investigated the effect of acute-phase levels of C-reactive protein (CRP) on cytokine production by pulmonary macrophages in the presence or absence of pulmonary surfactant. Both human alveolar and interstitial macrophages as well as human surfactant were obtained from multiple organ donor lungs. Precultured macrophages were stimulated with LPS alone or together with IFN-γ in the presence or absence of CRP, surfactant, and combinations. Releases of TNF-α and of IL-1β to the medium were determined. We found that CRP could modulate lung inflammation in humans by decreasing the production of proinflammatory cytokines by both alveolar and interstitial macrophages stimulated with LPS alone or together with IFN-γ. The potential interaction between CRP and surfactant phospholipids did not overcome the effect of either CRP or surfactant on TNF-α and IL-1β release by lung macrophages. On the contrary, CRP and pulmonary surfactant together had a greater inhibitory effect than either alone on the release of proinflammatory cytokines by lung macrophages.

C-REACTIVE PROTEIN AND STREPTOLYSIN O IN APOPTOSIS AND CYTOLYSIS

Shock ◽  
1997 ◽  
Vol 7 (Supplement) ◽  
pp. 119
Author(s):  
Alexander A. Butyugov ◽  
Peter G. Nazarov
Keyword(s):  
C Reactive Protein ◽  
Reactive Protein ◽  
Streptolysin O

Inhibitory effect of c-reactive protein on phospholipase D activity

Life Sciences ◽  
1993 ◽  
Vol 53 (5) ◽  
pp. 425-429 ◽  
Author(s):  
Shuji Mori ◽  
Yasunari Nakata ◽  
Hiroshi Endo
Keyword(s):  
Phospholipase D ◽  
Inhibitory Effect ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Phosphatidylcholine (lecithin) stimulating effect on pathogenic properties of pneumococcus

2014 ◽  
Vol 21 (1) ◽  
pp. 48-51
Author(s):  
A. S. Kvetnaya ◽  
L. I. Zhelezova
Keyword(s):  
Cell Wall ◽  
Hemolytic Activity ◽  
Teichoic Acid ◽  
Biological Properties ◽  
Pathogenic Factor ◽  
C Reactive Protein ◽  
Capsule Formation ◽  
Reactive Protein ◽  
Growth Stimulant

The authors have studied the effect of phosphatidylcholine (lecithin) - a derivative of choline - on the biological properties of streptococus pneumonia. The concentration of lecithin 0.01 g/l in a simple nutrient broth has a stimulating effect on proliferation, on in vitro stabilization of the population, and on pathogenic properties of the pneumococcus. Four - five times passaging of the strains on this medium (as opposed to the commonly used 20 % serum broth) retained the species and the typical properties of pneumococcus, but led to increased capsule formation, increased virulence and expressed β-hemolytic activity. These results suggest that phosphatidylcholine (lecithin), as the main supplier of pneumococcus growth stimulant - choline, has an expressing impact on the capsule formation - the main pathogenic factor, and on the substance of P-teichoic acid in the cell wall of pneumococcus that specifically interacts with the C-reactive protein.

scholarly journals Aqueous Extract of Carica Papaya Linn Roots Halts Sodium Arsenite-Induced Renal Inflammation through Inhibiting Adenosine Deaminase, 8-Hydroxy-2′-Deoxyguanosine, C-Reactive Protein and Inducible Nitric Oxide Synthase Activity

2017 ◽  
Vol 18 (4) ◽  
pp. 323-330 ◽  
Author(s):  
Oluwafemi Adeleke Ojo ◽  
Adebola Busola Ojo ◽  
Olukemi Adetutu Osukoya ◽  
Basiru Olaitan Ajiboye
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Aqueous Extract ◽  
Carica Papaya ◽  
Inhibitory Effect ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

AbstractObjectives: Inflammation plays a crucial role in many of the metabolic abnormalities. The prototypic marker of inflammation is C-reactive protein (CRP), Nitric Oxide (NO), inducible nitric oxide synthase (iNOS) and their inhibition is considered a promising strategy to combat inflammation. Here, we report the anti-inflammatory mechanism of Carica papaya root aqueous extract in sodium arsenic-induced renal dysfunction.Methodology: Thirty-five rats were used for the experiments. Griess assay was used to evaluate the inhibitory effect of Carica papaya roots aqueous extract on the overproduction of nitric oxide (NO). ELISA was used to determine the level of pro-inflammatory markers including c-reactive protein (CRP). ELISA was used to analyze 8-OHdG. The inhibitory effect on the enzymatic activity of inducible nitric oxide synthase (iNOS), adenosine deaminase (ADA), malondialdehyde (MDA) was tested by enzyme activity assay kits.Results:Carica papaya roots aqueous extract suppressed sodium arsenite-stimulated NO production and proinflammatory secretion, such as CRP. Carica papaya roots aqueous extract significantly (p < 0.05) decrease the activities of iNOS, 8-OHdG, ADA and MDA.Conclusion: These results indicated that potent inhibition on CRP, NO, iNOS, ADA, 8-OHdG might constitute the anti-inflammatory mechanism of Carica papaya roots aqueous extract.

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