Controlled release behavior of bioactive molecules from photo-reactive hyaluronic acid-alginate scaffolds

Anionic clay matrix acting as drug controlled release system have shown in last years a great potential for delivery of bioactive molecules and chemical therapeutics. This organic-inorganic nanohybrid system is high efficient offering an excellent protection of intercalated compounds from degradation. Compared to other nanoparticles used in medical area, anionic clays type layered double hydroxides have found to be biocompatible according to toxicological studies. Ampicillin containing MgAlLDHs and ZnAlLDH samples have been prepared following two routes: anion-exchange procedure and reconstruction from calcined layered double hydroxides. Solid samples have been characterized by FTIR and SEM-EDX highlighting the alteration of pristine LDHs structure when the antibiotic is introduced in the interlayer gallery.

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Pectin-Chitosan Multilayer Coated Microbeads of Diclofenac Sodium Prepared by Layer-by-Layer Technique

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.1060.45 ◽

2014 ◽

Vol 1060 ◽

pp. 45-49

Author(s):

Kamonrak Cheewatanakornkool ◽

Pornsak Sriamornsak

Keyword(s):

Controlled Release ◽

Drug Release ◽

Diclofenac Sodium ◽

Gastric Fluid ◽

Layer By Layer ◽

Release Behavior ◽

Freeze Dried ◽

Layer Technique ◽

Calcium Pectinate ◽

Layer By Layer Technique

The main objective of this study was to fabricate biopolymer-based microbeads, providing enteric properties and controlled release of diclofenac sodium, using layer-by-layer technique. The calcium pectinate microbeads have been designed and coated with chitosan and pectin multilayers. Drug release was performed in simulate gastric fluid (pH 1.2) for 2 hours, followed by pH 6.8 buffer for 8 hours. The effects of chitosan concentration, number of layer and drying technique on drug release were investigated. The results showed that the calcium pectinate microbeads could be simply prepared by ionotropic gelation and then coated with chitosan and pectin solutions using layer-by-layer procedure. The diameter of the microbeads ranged from 800 to 1000 μm for air-dried samples and from 1 to 2 mm for freeze-dried samples. The freeze-dried microbeads had a rough surface and many pores inside, as observed by SEM. The microbeads coated with 4% chitosan/4% pectin revealed a slower drug release than those coated with 1% chitosan/4% pectin and demonstrated a controlled release pattern. Moreover, different drying techniques and numbers of layer also influenced drug release behavior of the prepared microbeads.

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Synthesis, Characterization, and Magnetically Controlled Release Behavior of Novel Core−Shell Structural Magnetic Ibuprofen-Intercalated LDH Nanohybrids

The Journal of Physical Chemistry C ◽

10.1021/jp901060v ◽

2009 ◽

Vol 113 (28) ◽

pp. 12140-12148 ◽

Cited By ~ 76

Author(s):

Hui Zhang ◽

Dengke Pan ◽

Xue Duan

Keyword(s):

Controlled Release ◽

Core Shell ◽

Release Behavior

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Inhibition of interleukin-1beta-stimulated dedifferentiation of chondrocytes via controlled release of CrmA from hyaluronic acid-chitosan microspheres

BMC Musculoskeletal Disorders ◽

10.1186/s12891-015-0521-6 ◽

2015 ◽

Vol 16 (1) ◽

Cited By ~ 6

Author(s):

Bei-lei Ma ◽

Pang-Hu Zhou ◽

Ting Xie ◽

Lei Shi ◽

Bo Qiu ◽

...

Keyword(s):

Hyaluronic Acid ◽

Controlled Release ◽

Chitosan Microspheres ◽

Interleukin 1Beta

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PTMAc-PEG-PTMAc hydrogel modified by RGDC and hyaluronic acid promotes neural stem cells' survival and differentiation in vitro

RSC Advances ◽

10.1039/c7ra06614g ◽

2017 ◽

Vol 7 (65) ◽

pp. 41098-41104 ◽

Cited By ~ 6

Author(s):

Ruirui Yang ◽

Caixia Xu ◽

Tao Wang ◽

Yuanqi Wang ◽

Jingnan Wang ◽

...

Keyword(s):

Stem Cells ◽

Central Nervous System ◽

Nervous System ◽

Hyaluronic Acid ◽

Neural Stem Cells ◽

Biological Properties ◽

Central Nervous System Injury ◽

Bioactive Molecules

The enhancement of the biological properties of hydrogels by surface modifying with bioactive molecules is of great significance, especially for the treatment of central nervous system injury by combining engrafted cells.

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