scholarly journals Erratum to: The electro-weak couplings of the top and bottom quarks — global fit and future prospects

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Gauthier Durieux ◽  
Adrian Irles ◽  
Víctor Miralles ◽  
Ana Peñuelas ◽  
Martín Perelló ◽  
...  
Keyword(s):  
Top Quark ◽  
Current Data ◽  
Bottom Quarks ◽  
Future Prospects ◽  
Quark Decays ◽  
Global Fit

In the course of follow-up work a mistake was discovered in the parameterization of the dependence of the W-boson helicity fractions in top quark decays. The dependence on two operator coefficients, Cφtb and CbW, was erroneously omitted. Inclusion of this dependence leads to significantly stronger bounds on these operators from the current data and modifies also the HL-LHC prospects. The expectations for e+e− colliders are not affected. We present corrected results in this erratum.

scholarly journals The electro-weak couplings of the top and bottom quarks — Global fit and future prospects

2019 ◽  
Vol 2019 (12) ◽  
Author(s):  
Gauthier Durieux ◽  
Adrian Irles ◽  
Víctor Miralles ◽  
Ana Peñuelas ◽  
Martín Perelló ◽  
...  
Keyword(s):  
Bottom Quarks ◽  
Future Prospects ◽  
Global Fit

scholarly journals Indirect $$ \mathcal{CP} $$ probes of the Higgs-top-quark interaction: current LHC constraints and future opportunities

2020 ◽  
Vol 2020 (11) ◽  
Author(s):  
Henning Bahl ◽  
Philip Bechtle ◽  
Sven Heinemeyer ◽  
Judith Katzy ◽  
Tobias Klingl ◽  
...  
Keyword(s):  
Higgs Boson ◽  
Standard Model ◽  
Top Quark ◽  
Decay Channel ◽  
New Physics ◽  
Current Data ◽  
Quark Interaction ◽  
The Standard Model ◽  
Vector Bosons ◽  
Selection Of

Abstract The $$ \mathcal{CP} $$ CP structure of the Higgs boson in its coupling to the particles of the Standard Model is amongst the most important Higgs boson properties which have not yet been constrained with high precision. In this study, all relevant inclusive and differential Higgs boson measurements from the ATLAS and CMS experiments are used to constrain the $$ \mathcal{CP} $$ CP -nature of the top-Yukawa interaction. The model dependence of the constraints is studied by successively allowing for new physics contributions to the couplings of the Higgs boson to massive vector bosons, to photons, and to gluons. In the most general case, we find that the current data still permits a significant $$ \mathcal{CP} $$ CP -odd component in the top-Yukawa coupling. Furthermore, we explore the prospects to further constrain the $$ \mathcal{CP} $$ CP properties of this coupling with future LHC data by determining tH production rates independently from possible accompanying variations of the $$ t\overline{t}H $$ t t ¯ H rate. This is achieved via a careful selection of discriminating observables. At the HL-LHC, we find that evidence for tH production at the Standard Model rate can be achieved in the Higgs to diphoton decay channel alone.

scholarly journals Surgical treatment of recalcitrant gastroesophageal reflux disease in patients with systemic sclerosis: a systematic review

2021 ◽  
Author(s):  
Alberto Aiolfi ◽  
Mario Nosotti ◽  
Kazuhide Matsushima ◽  
Carolina Perali ◽  
Cristina Ogliari ◽  
...  
Keyword(s):  
Systematic Review ◽  
Systemic Sclerosis ◽  
Surgical Treatment ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Current Data ◽  
Current Evidence ◽  
Increased Risk

Abstract Introduction Gastroesophageal reflux disease (GERD) is frequently seen in patients with systemic sclerosis (SSc). Long-standing GERD may cause esophagitis, long-segment strictures, and Barrett’s esophagus and may worsen pre-existing pulmonary fibrosis with an increased risk of end-stage lung disease. Surgical treatment of recalcitrant GERD remains controversial. The purpose of this systematic review was to summarize the current data on surgical treatment of recalcitrant GERD in SSc patients. Materials and methods A systematic literature review according to PRISMA and MOOSE guidelines. PubMed, EMBASE, and Web of Science databases were consulted. Results A total of 101 patients were included from 7 studies. The age ranged from 34 to 61 years and the majority were females (73.5%). Commonly reported symptoms were heartburn (92%), regurgitation (77%), and dysphagia (74%). Concurrent pulmonary disease was diagnosed in 58% of patients. Overall, 63 patients (62.4%) underwent open fundoplication, 17 (16.8%) laparoscopic fundoplication, 15 (14.9%) Roux en-Y gastric bypass (RYGB), and 6 (5.9%) esophagectomy. The postoperative follow-up ranged from 12 to 65 months. Recurrent symptoms were described in up to 70% and 30% of patients undergoing fundoplication and RYGB, respectively. Various symptoms were reported postoperatively depending on the type of surgical procedures, anatomy of the valve, need for esophageal lengthening, and follow-up. Conclusions The treatment of recalcitrant GERD in SSc patients is challenging. Esophagectomy should be reserved to selected patients. Minimally invasive RYGB appears feasible and safe with promising preliminary short-term results. Current evidence is scarce while a definitive indication about the most appropriate surgical treatment is lacking.

scholarly journals Transvaginal Hybrid-NOTES procedures—do they have a negative impact on pregnancy and delivery?

2021 ◽  
Author(s):  
Panagiotis Thomaidis ◽  
Niklas J. Weltermann ◽  
Claudia S. Seefeldt ◽  
Dana C. Richards ◽  
Axel Sauerwald ◽  
...  
Keyword(s):  
Negative Impact ◽  
Male Partner ◽  
Current Data ◽  
Reproductive Age ◽  
Negative Effects ◽  
Desire For Children ◽  
Pregnancy And Delivery ◽  
Hybrid Notes ◽  
Type Of Delivery

Abstract Purpose We conducted a retrospective observational study in order to identify negative effects of NOTES procedures (Natural Orifice Transluminal Endoscopic Surgery) with transvaginal specimen removal on pregnancy and delivery. Methods From the total population of 299 patients in our NOTES registry, we tried to contact the 121 patients who were of reproductive age (≤ 45 years) at the time of a transvaginal NOTES procedure. They were interviewed by telephone regarding their desire for children, post NOTES-operation pregnancies, and type of delivery using a structured questionnaire. The collected data was analyzed and compared with current data. Results We were able to contact 76 patients (follow-up rate: 62.8%) with a median follow-up of 77 months after surgery (33–129 months). Twenty of 74 participating patients had a desire for children (27.0%). One of them and another's male partner were diagnosed as infertile. Regarding the remaining 18 patients, 14 became pregnant, and three of them became pregnant twice. Considering these 17 pregnancies, there was one miscarriage (5.9%) and one twin birth (5.9%). On average, childbirth occurred 44 months after the NOTES procedure. With regard to the type of delivery, 10 vaginal births (58.8%) and 7 caesarean sections (41.2%) occurred. Thus, the rate of fulfilled desire for children was 77.8%. Compared with the literature, no difference to the normal course could be detected. Conclusion There is no sign that the transvaginal approach in Hybrid-NOTES, with removal of the specimen through the vagina, has a negative effect on conception, the course during pregnancy, or the type of delivery.

scholarly journals Measurement of the helicity fractions ofWbosons from top quark decays using fully reconstructedtt¯events with CDF II

2007 ◽  
Vol 75 (5) ◽  
Author(s):  
A. Abulencia ◽  
J. Adelman ◽  
T. Affolder ◽  
T. Akimoto ◽  
M. G. Albrow ◽  
...  
Keyword(s):  
Top Quark ◽  
Quark Decays ◽  
Cdf Ii

scholarly journals Long Term Real-World Outcomes of Trifluridine/Tipiracil in Metastatic Colorectal Cancer—A Single UK Centre Experience

2021 ◽  
Vol 28 (3) ◽  
pp. 2260-2269
Author(s):  
Daniel Tong ◽  
Lei Wang ◽  
Jeewaka Mendis ◽  
Sharadah Essapen
Keyword(s):  
Colorectal Cancer ◽  
Metastatic Colorectal Cancer ◽  
Real World ◽  
Systemic Treatment ◽  
Progression Free Survival ◽  
Median Number ◽  
Current Data ◽  
Real World Data

In the UK, Trifluridine-tipiracil (Lonsurf) is used to treat metastatic colorectal cancer in the third-line setting, after prior exposure to fluoropyrimidine-based regimes. Current data on the real-world use of Lonsurf lack long-term follow-up data. A retrospective evaluation of patients receiving Lonsurf at our Cancer Centre in 2016–2017 was performed, all with a minimum of two-year follow-up. Fifty-six patients were included in the review. The median number of cycles of Lonsurf administered was 3. Median follow-up was 6.0 months, with all patients deceased at the time of analysis. Median progression-free survival (PFS) was 3.2 months, and overall survival (OS) was 5.8 months. The median interval from Lonsurf discontinuation to death was two months, but seven patients received further systemic treatment and median OS gained was 12 months. Lonsurf offered a slightly better PFS but inferior OS to that of the RECOURSE trial, with PFS similar to real-world data previously presented. Interestingly, 12.5% had a PFS > 9 months, and this cohort had primarily left-sided and RAS wild-type disease. A subset received further systemic treatment on Lonsurf discontinuation with good additional OS benefit. Lonsurf may alter the course of disease for a subset of patients, and further treatment on progression can be considered in carefully selected patients.

scholarly journals Finite width effects in top quark decays

1995 ◽  
Vol 347 (3-4) ◽  
pp. 394-398 ◽  
Author(s):  
Gregory Mahlon ◽  
Stephen Parke
Keyword(s):  
Top Quark ◽  
Finite Width ◽  
Quark Decays

Abstract 1924: Longterm Outcome Of Pediatric Patients With Discrete Subaortic Stenosis

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Christian Drolet ◽  
Joaquim Miro ◽  
Jean-Marc Côté ◽  
Letizia Gardin ◽  
Charles V Rohlicek
Keyword(s):  
Pediatric Patients ◽  
Ventricular Outflow Tract ◽  
Aortic Insufficiency ◽  
Left Ventricular ◽  
Current Data ◽  
Subaortic Stenosis ◽  
Childhood And Adolescence ◽  
Discrete Subaortic Stenosis ◽  
Left Ventricular Outflow

INTRODUCTION: We previously reported the clinical outcomes of a large pediatric cohort with discrete subaortic stenosis (SubAS) 1 . While patients with more significant left ventricular outflow tract obstruction (LVOTO) at diagnosis progressed rapidly others with mild LVOTO at presentation showed little progression of obstruction or aortic insufficiency (AI). A limitation of our previous study was a relatively short follow-up period. OBJECTIVE: To extend the follow-up of our previously described cohort with SubAS. METHODS: Information was gathered retrospectively on 71 previously identified patients diagnosed with SubAS from 1985–1998. RESULTS: Current data was available on 61/71 patients. At diagnosis the average age was 5.2±0.5 years (mean±SEM), peak LVOT Doppler gradient (Echograd) was 30±3 mmHg, and AI (all mild) was present in 25%. At last assessment the average age was 15.7±0.4 years. Twenty patients were followed only medically and were last reassessed 9.2±1.0 years after diagnosis at 15.8±0.7 years of age. The mean Echograd was unchanged from diagnosis (19±2 vs. 19±3 mmHg). The incidence of AI on echocardiography (all mild) increased from 5% to 55% although none was detectable by auscultation. Forty-one patients underwent surgery 3.0±0.5 years after diagnosis at 7.4±0.6 years of age. The Echograd at diagnosis was 35±3 and increased to 61±6 mmHg pre-operatively. Ten patients were re-operated 5.7±0.7 years after the first surgery and 2 patients had a second re-operation. The last follow up of the operated patients occurred at 15.7±0.6 years of age. At that time the Echograd was 16±3 mmHg and the incidence of AI by echocardiography had increased to 98% (36 mild & 3 moderate) but was evident on auscultation in only 25%. CONCLUSIONS: This study represents the largest and longest contemporary follow-up of pediatric patients with discrete SubAS. Our results indicate that some patients with SubAS show significant LVOTO at diagnosis and subsequent progression. Surgery in these patients provides good relief of LVOTO but does not eliminate AI. The one third of patients presenting with mild LVOTO and AI show little progression through childhood and adolescence. We suggest that the latter can be safely followed medically. 1) Rohlicek et al. Heart 82:708;1999

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