scholarly journals Peroxiredoxins as Markers of Oxidative Stress in IgA Nephropathy, Membranous Nephropathy and Lupus Nephritis

2021 ◽  
Vol 70 (1) ◽  
Author(s):  
Natalia Krata ◽  
Bartosz Foroncewicz ◽  
Radosław Zagożdżon ◽  
Barbara Moszczuk ◽  
Magdalena Zielenkiewicz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lupus Nephritis ◽  
Iga Nephropathy ◽  
Membranous Nephropathy ◽  
Diagnostic Procedures ◽  
Renal Diseases ◽  
Serum Concentrations ◽  
Immune Mediated ◽  
Markers Of Oxidative Stress ◽  
Estimated Glomerular Filtration Rates

AbstractIgA nephropathy (IgAN), membranous nephropathy (MN), and lupus nephritis (LN) represent important causes of chronic kidney disease. They belong to the immune-mediated glomerulonephritis (GNs), and have distinct pathogenesis, distinct clinical courses, and variable responses to treatment. Therefore, specific diagnostic procedures are necessary for more effective patient management. Recently, a role for oxidative stress has been proposed in various renal disorders. Thus, molecules related to oxidative stress, such as 2-Cys-peroxiredoxins (PRDXs), may represent plausible candidates for biomarkers in renal pathologies. The aim of this study was to assess whether there are differences between individual GNs and healthy controls in the context of PRDXs serum concentration. We enrolled 108 patients with biopsy-proven IgAN (47), MN (26), LN (35) and 30 healthy age- and sex-matched controls. The serum concentrations of PRDX 1–5 were measured with ELISA assays and correlated with demographic and clinical data. The PRDXs’ concentration varied depending on the GN type. We also observed an association of PRDXs with lower estimated glomerular filtration rates, complement, hemoglobin, and body mass index. Our study indicates that individual PRDX can play roles in pathophysiology of selected GNs and that their serum concentrations may become useful as a new supplementary diagnostic markers in IgAN, MN as well as LN. The results of this study open a new avenue for prospective research on PRDXs in renal diseases.

scholarly journals SP282URINARY PROTEOMIC MARKERS OF IGA NEPHROPATHY, LUPUS NEPHRITIS AND MEMBRANOUS NEPHROPATHY

2019 ◽  
Vol 34 (Supplement_1) ◽  
Author(s):  
Barbara Moszczuk ◽  
Natalia Krata ◽  
Tomasz Pilżys ◽  
Damian Garbicz ◽  
Michał Marcinkowski ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Iga Nephropathy ◽  
Membranous Nephropathy

scholarly journals C4d deposition in native kidney disease and its correlation with proteinuria and serum urea/creatinine

2018 ◽  
Vol 6 (12) ◽  
pp. 3935
Author(s):  
Sant Pandey ◽  
Sucheta Yadav ◽  
Suresh Babu ◽  
Ashutosh Kumar ◽  
Bhupendra P. Singh ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Iga Nephropathy ◽  
Membranous Nephropathy ◽  
Tertiary Care ◽  
Covalent Bond ◽  
Renal Diseases ◽  
P Value ◽  
Age Group ◽  
Hypertensive Nephropathy ◽  
Cross Sectional

Background: C4d is a well-known biomarker of the complement cascade. It is derived from cleavage of the labile thioester bond of C4b. This cleavage provides C4d a covalent bond which helps C4d to anchor to nearby cells where immune complexes are deposited. Antibodies dissociate naturally because of relatively weak hydrostatic and Van der Waals forces between antigens and antibodies, whereas covalent bond of C4d has a much longer half-life. For this reason, C4d serves as a footprint of complement activation.Methods: This was a retrospective and prospective cross-sectional study, done at our tertiary care hospital.Results: Authors evaluated 50 cases and 10 controls to adjudge the significance of C4d deposits in native renal diseases. Majority of the patients (44%) were in the age group of 10-20 years followed by 20% in the age group of 31-40 years. 62% of study population were male. Majority of patients were diagnosed with FSGS (16%), followed by membranous nephropathy (14%), lupus nephropathy (14%) and IgA nephropathy (12%). There was correlation of intensity expression of glomerular C4d deposits with presenting 24 hours urinary protein level at the time of biopsy (p value=0.027) but no correlation with urea/creatinine.Conclusions: All patients diagnosed with membranous nephropathy, IgA nephropathy and hypertensive nephropathy showed glomerular C4d deposits, and also diagnosed with IgA nephropathy, post infectious glomerulonephritis, lupus nephritis, minimal change disease, acute/chronic tubulointerstitial nephritis, diabetic nephropathy, hypertensive nephropathy showed tubular C4d deposits. All patients diagnosed with diabetic nephropathy and hypertensive nephropathy showed arterial C4d deposits.

scholarly journals Serum concentrations of nitrite and malondialdehyde as markers of oxidative stress in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors

2012 ◽  
Vol 34 (5) ◽  
pp. 352-355 ◽  
Author(s):  
Maria Juracy Petrola ◽  
Alana Joselina Montenegro de Castro ◽  
Maria Helena da Silva Pitombeira ◽  
Maritza Cavalcante Barbosa ◽  
Acy Telles de Souza Quixadá ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Myeloid Leukemia ◽  
Tyrosine Kinase ◽  
Tyrosine Kinase Inhibitors ◽  
Myeloid Leukemia ◽  
Kinase Inhibitors ◽  
Serum Concentrations ◽  
Markers Of Oxidative Stress

scholarly journals P0468RENAL OUTCOME AND MORTALITY OF GLOMERULONEPHRITIS IN A THAI TERTIARY CARE CENTER

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Chitimaporn Janphram ◽  
Chagriya Kitiyakara
Keyword(s):  
Multiple Myeloma ◽  
Diabetic Nephropathy ◽  
Lupus Nephritis ◽  
Iga Nephropathy ◽  
Immune Complex ◽  
Membranous Nephropathy ◽  
Minimal Change Disease ◽  
Kidney Biopsy ◽  
Minimal Change ◽  
Different Types

Abstract Background and Aims Glomerulonephritis (GN) is a common cause of End-stage renal disease (ESRD) in Asia and around the world. Most studies from renal registries have focused on the prevalence or clinical characteristics of patients with GN. Only a few registry-based data have focused on mortality and ESRD risks of different types of GN. There is limited data from low to middle income countries or from Southeast Asia. The objectives of this study were to evaluate the mortality and ESRD rates among patients with different types of GN referred for a kidney biopsy at a Thai tertiary care hospital. Method In this retrospective study, the data of patients (n=1,025) referred for a kidney biopsy at Ramathibodi Hospital from 1 January 2011 to 31 December 2017 were reviewed. Patients were classified in to 11 different types of GN. Patient death and cause of death data was obtained from National Census office. ESRD data was obtained from the Thailand Nephrology Society ESRD registry which includes all patients on renal replacement therapies for greater than 3 months. Results Patients with inadequate specimen (n=66) or non-glomerular diseases (n=95) were excluded. Data from 864 patients with GN was analyzed. The age at kidney biopsy was 43.9 ± 16.8 years, median eGFR (CKD-EPI) was 42 (IQR 13-83) mL/min/1.73m2. The male:female ratio was 0.6. The prevalence of GN were: Lupus nephritis (26.8%), IgA nephropathy (18.2%), focal segmental glomerulosclerosis (FSGS 12.6 %), membranous nephropathy (11.9 %), diabetic nephropathy (10.8%), minimal change disease (9.7%), hypertensive nephrosclerosis (4.3%), pauci-immune complex glomerulonephritis (2.3%), membranoproliferative glomerulonephritis (MPGN 1.6%) and multiple myeloma (1.4%) Median time follow up was 42 (IQR 23-62) months. Overall mortality was 13 %. Lupus nephritis accounted for highest proportion of all deaths (25%), followed by diabetic nephropathy (19.1%), FSGS (9%). Listed causes of deaths were: sepsis 22% and chronic kidney disease 8%. Mortality rates by disease were: multiple myeloma (50%), diabetic nephropathy (28.7%), MPGN (21.4%), pauci-immune complex GN (20%), hypertensive nephrosclerosis (15.8%), lupus nephritis (14.6%), membranous nephropathy (8.7%), FSGS (8.2%), minimal change disease (5.8%), IgA nephropathy (4.4%) The incidence of ESRD was 14 %. LN accounted for the highest proportion (29%) of all ESRD, followed by IgA nephropathy (14%), and membranous nephropathy (13%). The rates of ESRD by disease were: multiple myeloma (33.3%), lupus nephritis (15%), membranous nephropathy (14.5%), minimal change disease (14.3%), MPGN (14.2%), IgA nephropathy (10.1%), FSGS (10.1%), diabetic nephropathy (7.4%), pauci-immune complex glomerulonephritis (5%), hypertensive nephroclerosis (2.6%). Conclusion Lupus nephritis is the most common GN and accounted for the highest proportion of all deaths and ESRD in this Thai cohort. IgA nephropathy is the most common primary GN and an important cause of ESRD, but the mortality rate is low compared to other GN. Membranous nephropathy has comparable prevalence to FSGS, but is a more important contributor to ESRD. Diabetic nephropathy has higher rate of mortality than ESRD. Multiple myleloma has the highest rate of both death and ESRD.

scholarly journals Rapidly Progressive Glomerulonephritis Secondary to IgA Nephropathy in a Patient with Systemic Lupus Erythematosus

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Amol M. Patel ◽  
Lily Anne Romero Karam ◽  
Stephanie C. Fuentes Rojas ◽  
Warren E. Redfearn ◽  
Luan D. Truong ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Acute Kidney Injury ◽  
Lupus Nephritis ◽  
Iga Nephropathy ◽  
Lupus Erythematosus ◽  
Kidney Injury ◽  
Disease Stage ◽  
Immunofluorescent Staining ◽  
Renal Diseases ◽  
Systemic Lupus

Lupus nephritis is a common manifestation of systemic lupus erythematosus (SLE). IgA nephropathy is a common type of primary glomerulonephritis. Renal manifestations in SLE patients are often due to lupus nephritis; however, renal diseases unrelated to lupus nephritis are rarely reported. While crescentic IgA nephropathy with rapid clinical progression is rare, its development in patients with SLE in the absence of lupus nephritis is even more unusual. A 74-year-old woman with a history of SLE without known renal involvement, chronic kidney disease stage IIIa, congestive heart failure, hypertension, and type 2 diabetes mellitus presented with acute kidney injury. Her creatinine continued to rise rapidly. Renal biopsy revealed mesangial proliferative glomerulonephritis with crescent formation. Immunofluorescent staining showed IgA and C3 mesangial deposition and absence of C4 and C1q, consistent with IgA nephropathy. She received a course of methylprednisolone and plasmapheresis. Unfortunately, her renal function continued to deteriorate, and she was started on hemodialysis which was continued after hospital discharge. This case illustrates crescentic IgA nephropathy without lupus nephritis as the cause of acute kidney injury in a patient with SLE. It highlights the observation that renal diseases other than lupus nephritis can develop in SLE patients.

scholarly journals Socioeconomic Position and Incidence of Glomerular Diseases

2020 ◽  
Vol 15 (3) ◽  
pp. 367-374 ◽  
Author(s):  
Mark Canney ◽  
Dilshani Induruwage ◽  
Anahat Sahota ◽  
Cathal McCrory ◽  
Michelle A. Hladunewich ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Confidence Interval ◽  
Iga Nephropathy ◽  
Socioeconomic Position ◽  
Membranous Nephropathy ◽  
Rate Ratio ◽  
Population Level ◽  
Income Quintile ◽  
Inverse Association ◽  
Glomerular Diseases

Background and objectivesSocial deprivation is a recognized risk factor for undifferentiated CKD; however, its association with glomerular disease is less well understood. We sought to investigate the relationship between socioeconomic position and the population-level incidence of biopsy-proven glomerular diseases.Design, setting, participants, & measurementsIn this retrospective cohort study, a provincial kidney pathology database (2000–2012) was used to capture all incident cases of membranous nephropathy (n=392), IgA nephropathy (n=818), FSGS (n=375), ANCA-related GN (ANCA-GN, n=387), and lupus nephritis (n=389) in British Columbia, Canada. Quintiles of area-level household income were used as a proxy for socioeconomic position, accounting for regional differences in living costs. Incidence rates were direct standardized to the provincial population using census data for age and sex and were used to generate standardized rate ratios. For lupus nephritis, age standardization was performed separately in men and women.ResultsA graded increase in standardized incidence with lower income was observed for lupus nephritis (P<0.001 for trend in both sexes) and ANCA-GN (P=0.04 for trend). For example, compared with the highest quintile, the lowest income quintile had a standardized rate ratio of 1.7 (95% confidence interval, 1.19 to 2.42) in women with lupus nephritis and a standardized rate ratio of 1.5 (95% confidence interval, 1.09 to 2.06) in ANCA-GN. The association between income and FSGS was less consistent, in that only the lowest income quintile was associated with a higher incidence of disease (standardized rate ratio, 1.55; 95% confidence interval, 1.13 to 2.13). No significant associations were demonstrated for IgA nephropathy or membranous nephropathy.ConclusionsUsing population-level data and a centralized pathology database, we observed an inverse association between socioeconomic position and the standardized incidence of lupus nephritis and ANCA-GN.

scholarly journals P88 Cell free DNA bacterial sequences in patients with lupus nephritis differ from patients with IgA nephropathy and membranous nephropathy

2020 ◽  
Author(s):  
Bartosz Foroncewicz ◽  
Krzysztof Mucha ◽  
Arkadiusz Gładki ◽  
Barbara Moszczuk ◽  
Natalia Krata ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Iga Nephropathy ◽  
Membranous Nephropathy ◽  
Cell Free Dna ◽  
Free Dna

scholarly journals GLOMERULAR DISEASES IN MADINA REGION;

2019 ◽  
Vol 26 (04) ◽  
Author(s):  
Adil Manzoor ◽  
Imtiaz Bhatt ◽  
Rehan Javed
Keyword(s):  
Lupus Nephritis ◽  
Membranous Nephropathy ◽  
Minimal Change Disease ◽  
Epidemiological Data ◽  
Glomerular Disease ◽  
Renal Diseases ◽  
Glomerular Diseases ◽  
Thin Basement Membrane Nephropathy ◽  
Disease Patterns ◽  
Arabian Population

Objectives: The study is designed to get useful information and epidemiological data for clinical practice and investigations regarding glomerular disease frequencies in Madina region.  Study Design & Setting: Single-center retrospective study at King Fahd Hospital Madina. Period: 01 year (March 2016- March 2017). Methods: All native renal biopsies were studied for the period of 1 year (March 2016- March 2017). Only glomerular disease patterns were analyzed. The diagnosis of each case was based on histological, immunopathological and clinical features. Results: A total of 44 biopsies were Included. Primary glomerular diseases in 52.27% of all biopsies studied. The most common primary disease was Membranous Nephropathy which accounts for 20.45%. Focal and Segmental Glomerulosclerosis (FSGS) (9%), Minimal change disease (4.54%), C3 glomerulopathy  (4.54%), IGA Nephropathy (4.54%), Non-IgA Mesangial Proliferative GN(2.27%), Crescentic Glomerulonephritis (GN) (2.27%), Post lnfectlous GN(2.27%), Thin Basement Membrane Nephropathy(2.27%)  as primary GN. Secondary glomerular diseases in 47.73%. Lupus Nephritis corresponded to 34.09% of the entire series. Conclusions: FSGS has been the most frequent type of glomerulopathy in Saudi Arabian population according to previously available data from local studies but in our study the cases of Membranous Nephropathy were high .Lupus Nephritis remain above the list as a cause of secondary glomerular disease. The reasons for these findings are unclear but this information is an important contribution towards understanding the prevalence of renal diseases In Saudi Arabia.

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