Impact of changes in metabolic control on progression to photocoagulation for clinically significant macular oedema: a 20 year study of type 1 diabetes

Abstract Background Dental caries and type 1 diabetes are responsible for a large burden of global disease; however, the exact prevalence of dental caries among children and adolescents with type 1 diabetes remains controversial, and no quantitative meta-analysis exists. Thus, we performed a meta-analysis to evaluate the prevalence of dental caries among children and adolescents with type 1 diabetes. Methods We performed a systematic search strategy using PubMed, EMBASE and China National Knowledge Infrastructure for relevant studies investigating the prevalence of dental caries in children and adolescents with type 1 diabetes from July 1971 until December 2018. The pooled prevalence with 95% confidence intervals (95%CIs) and subgroup analyses were calculated using a random effects model. Results After screening 358 non-duplicated articles, a total of 10 articles involving 538 individuals were included. The overall prevalence of dental caries among children and adolescents with type 1 diabetes was 67% (95% CI: 0.56–0.77%; I2 = 83%). The prevalence was highest in South America (84%) and lowest in diabetic patients with good metabolic control (47%). Conclusions The prevalence of dental caries was high among children and adolescents with type 1 diabetes. Screening and preventive treatment should be included in dental clinical routines for diabetic children and adolescents, especially in those with poor metabolic control.

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Metabolic Control, Residual Insulin Secretion and Self-care Behaviours in a Defined Group of Patients with Type 1 Diabetes

Upsala Journal of Medical Sciences ◽

10.3109/03009739109179258 ◽

1991 ◽

Vol 96 (1) ◽

pp. 47-61 ◽

Cited By ~ 4

Author(s):

Karin Wikblad ◽

Kent Montin ◽

Lars Wibell

Keyword(s):

Type 1 Diabetes ◽

Insulin Secretion ◽

Metabolic Control ◽

Self Care

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The relation between awareness of personal resources and metabolic control in children and adolescents with type 1 diabetes

Pediatric Diabetes ◽

10.1111/pedi.12177 ◽

2014 ◽

Vol 16 (6) ◽

pp. 454-461 ◽

Cited By ~ 4

Author(s):

Maren Blicke ◽

Ulrike Körner ◽

Patricia Nixon ◽

Burak Salgin ◽

Thomas Meissner ◽

...

Keyword(s):

Type 1 Diabetes ◽

Children And Adolescents ◽

Metabolic Control ◽

Personal Resources

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The effect of the COVID-19 pandemic on metabolic control in children with type 1 diabetes: a single-center experience

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2021-0509 ◽

2021 ◽

Vol 0 (0) ◽

Author(s):

Emre Sarıkaya ◽

Dilek Çiçek ◽

Ebru Gök ◽

Leyla Kara ◽

Uğur Berber ◽

...

Keyword(s):

Type 1 Diabetes ◽

Metabolic Control ◽

Glycosylated Hemoglobin ◽

Emergency Admissions ◽

Single Center Experience ◽

Number Of Patients ◽

Significant Difference ◽

Before And After ◽

One Year

Abstract Objectives Coronavirus disease 2019 has caused a major epidemic worldwide, and lockdowns became necessary in all countries to prevent its spread. This study aimed to evaluate the effects of staying-at-home practices on the metabolic control of children and adolescents with type 1 diabetes during the pandemic period. Materials and Methods Eighty-nine patients younger than 18 years old who were diagnosed with type 1 diabetes at least one year before the declaration of the pandemic were included in the study. The last visit data of the patients before and after the declaration of the pandemic, and the frequency of presentation of diabetes-related emergencies from one year after diagnosis of type 1 diabetes to the declaration of the pandemic, and from the declaration of the pandemic to the last visit after the pandemic declaration were compared. Results The total number of patients was 89, and 48 (53.9%) were boys. The mean (± standard deviation [SD]) age at diagnosis was 8.4 ± 3.7 years (boys 7.9 ± 3.6 years; girls 8.9 ± 3.9 years). There was no statistically significant difference when the SD values of the anthropometric measurements, and the glycosylated hemoglobin (HbA1c) and lipid profile tests were compared. However, the frequency of admission to the emergency service related to diabetes was significantly different. Conclusions Although the pandemic did not significantly affect the metabolic and glycemic controls of the children with type 1 diabetes included in this study, an increase in the frequency of diabetes-related emergency admissions was noted.

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Impact of ELKa, the Electronic Device for Prandial Insulin Dose Calculation, on Metabolic Control in Children and Adolescents with Type 1 Diabetes Mellitus: A Randomized Controlled Trial

Journal of Diabetes Research ◽

10.1155/2017/1708148 ◽

2017 ◽

Vol 2017 ◽

pp. 1-9 ◽

Cited By ~ 4

Author(s):

Agnieszka Kowalska ◽

Katarzyna Piechowiak ◽

Anna Ramotowska ◽

Agnieszka Szypowska

Keyword(s):

Diabetes Mellitus ◽

Type 1 Diabetes ◽

Type 1 Diabetes Mellitus ◽

Metabolic Control ◽

Electronic Device ◽

Intervention Group ◽

Insulin Dosage ◽

Control Group ◽

Prandial Insulin

Background. The ELKa system is composed of computer software, with a database of nutrients, and a dedicated USB kitchen scale. It was designed to automatize the everyday calculations of food exchanges and prandial insulin doses. Aim. To investigate the influence of the ELKa on metabolic control in children with type 1 diabetes mellitus (T1DM). Methods. A randomized, parallel, open-label clinical trial involved 106 patients aged <18 years with T1DM, HbA1C≤10%, undergoing intensive insulin therapy, allocated to the intervention group, who used the ELKa (n=53), or the control group (n=53), who used conventional calculation methods. Results. After the 26-week follow-up, the intention-to-treat analysis showed no differences to all endpoints. In per protocol analysis, 22/53 (41.5%) patients reporting ELKa usage for >50% of meals achieved lower HbA1C levels (P=0.002), lower basal insulin amounts (P=0.049), and lower intrasubject standard deviation of blood glucose levels (P=0.023) in comparison with the control. Moreover, in the intervention group, significant reduction of HbA1C level, by 0.55% point (P=0.002), was noted. No intergroup differences were found in the hypoglycemic episodes, BMI-SDS, bolus insulin dosage, and total daily insulin dosage. Conclusions. The ELKa system improves metabolic control in children with T1DM under regular usage. The trial is registered at ClinicalTrials.gov, number NCT02194517.

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