Development of a prediction model for fatal and non-fatal coronary heart disease and cardiovascular disease in patients with newly diagnosed type 2 diabetes mellitus: The Basque Country Prospective Complications and Mortality Study risk engine (BASCORE)

Abstract The prospective study analyses prevalence of coronary heart disease, stroke, elevated serum levels of ALT and GGT and prevalence of cancer diseases in patients with newly diagnosed type 2 diabetes mellitus, and usage of this epidemiological data in everyday clinical practice. Outpatients with newly diagnosed type 2 diabetes mellitus were monitoring during the period of August 2007 - August 2011. The patients with previously treated type 2 diabetes mellitus were eliminated from the monitoring. The population consists of 117 males and 83 females aged 30 to 92 years sent by GPs and various specialists. The relatively low prevalence of known coronary artery disease was recorded in men (34%) and in women (19%). Prevalence of stroke history was confirmed in 12% of men and 7% of women. The elevated serum ALT levels > 0.55 μkat/l was recorded in 45% of men and 45% of women and elevated serum GGT levels > 0.45 μkat/l was recorded in 81% of men and 68% of women. Prevalence of cancer diseases was recorded 5% in women and 5.26% of men. In the studied group of patients there was recorded the occurrence of colon cancer in men over 64 years old and the occurrence of breast cancer, endometrial cancer and colon cancer in women over 62 years old.

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Introduction to the causes of cardiovascular disease and type 2 diabetes mellitus, South Asians, and the structure and approach of this book

Epidemic of Cardiovascular Disease and Diabetes ◽

10.1093/med/9780198833246.003.0001 ◽

2019 ◽

pp. 1-37

Author(s):

Raj S. Bhopal

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Cardiovascular Disease ◽

Coronary Heart Disease ◽

South Asians ◽

Clinical Care ◽

European Origin ◽

Causal Explanations ◽

Rich Countries

Coronary heart disease (CHD) and stroke, collectively cardiovascular disease (CVD), are caused by narrowing and blockage of the arteries supplying the heart and brain, respectively. In type 2 diabetes (DM2) insulin is insufficient to maintain normal blood glucose. Until the 1980s, CHD, stroke, and DM2 were seen as problems of the modern lifestyles of rich countries. South Asians should have been protected, e.g. by less smoking, more vegetarianism, and lower levels of obesity. However, the contrary was true and South Asians have high susceptibility to these diseases. The established causes cannot account for the susceptibility. For example, obesity tends to be lower in South Asians than in European origin people but DM2, though caused by obesity, is about three times commoner. About ten major groups of explanations have been published. The aim of this book is to produce a synthesis of the causal explanations to guide prevention, clinical care, and research.

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64 Ten-year incidence of cardiovascular disease (CVD) in newly-diagnosed type 2 diabetes mellitus (DM2): Role of insulin resistance (IR)

Nutrition Metabolism and Cardiovascular Diseases ◽

10.1016/s0939-4753(05)80064-x ◽

2005 ◽

Vol 15 ◽

pp. S15

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Cardiovascular Disease ◽

Type 2 Diabetes Mellitus ◽

Newly Diagnosed

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Prevention Of Coronary Heart Disease And Stroke Complications In Type 2 Diabetes Mellitus: An Observational, Prospective Study

Romanian Journal of Diabetes Nutrition and Metabolic Diseases ◽

10.1515/rjdnmd-2015-0022 ◽

2015 ◽

Vol 22 (2) ◽

pp. 175-185

Author(s):

Ramona Maria Ştefan ◽

Cristina Niţă ◽

Anca Crăciun ◽

Adriana Rusu ◽

Nicolae Hâncu

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Type 2 Diabetes ◽

Coronary Heart Disease ◽

Type 2 Diabetes Mellitus ◽

Control Group ◽

Newly Diagnosed ◽

Intensive Group

AbstractBackground and Aims: We assessed the effect of intensive therapy on modifiable cardiovascular (CV) risk factors and CV risk as compared to conventional therapy in patients with newly diagnosed type 2 diabetes mellitus (T2DM).Material and Methods: This was an observational, prospective study, conducted in Romania. During 1-year follow-up period the enrolled participants received either multi-factorial pharmacotherapy associated with intensive therapeutic education (Intensive group), or conventional therapy (Control group). Current analysis included data (anthropometric measurements, blood pressure and biochemical parameters) recorded at months (M) 0, 6 and 12. CV risk was calculated at M1 and M12 using the UK Prospective Diabetes Study Risk Engine.Results: 138 patients aged 57.02±10.05 years were included in this analysis (69 in each group). At M6 and M12 a significant improvement of the majority of the modifiable risk factors in the Intensive group compared to the Control group was observed. At M12, coronary heart disease (CHD)/fatal-CHD risks were significantly lower in the Intensive (7.5%/3.1%) than in the Control (17.95%/10.3%) group (p<0.05). A similar trend was observed for the stroke/fatal-stroke risks.Conclusions: CHD/fatal-CHD and stroke/fatal-stroke risk burden decreased in newly diagnosed diabetic patients following multi-factorial pharmacotherapy association with intensive lifestyle changes during 1-year follow-up.

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