Risk factors associated with the occurrence of hip fracture in Japanese patients with rheumatoid arthritis: a prospective observational cohort study

Objective.To evaluate the rates of retention and discontinuation of adalimumab (ADA) due to efficacy and safety in Japanese patients with rheumatoid arthritis (RA).Methods.All patients with RA (n = 476) who were treated with ADA in the Tsurumai Biologics Communication Registry were enrolled.Results.The retention rate of ADA was 46% at 5 years. When focusing on insufficient efficacy, previous biologics use and high baseline disease activity were significant risk factors for up to 1 year. Methotrexate (MTX) use was a significantly low risk factor after 1 year of treatment.Conclusion.Concomitant MTX contributes to the longterm efficacy of ADA therapy.

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Risk factors associated with revision for prosthetic joint infection after hip replacement: a prospective observational cohort study

The Lancet Infectious Diseases ◽

10.1016/s1473-3099(18)30345-1 ◽

2018 ◽

Vol 18 (9) ◽

pp. 1004-1014 ◽

Cited By ~ 53

Author(s):

Erik Lenguerrand ◽

Michael R Whitehouse ◽

Andrew D Beswick ◽

Setor K Kunutsor ◽

Ben Burston ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Prosthetic Joint Infection ◽

Hip Replacement ◽

Joint Infection ◽

Observational Cohort Study ◽

Prospective Observational Cohort Study ◽

Factors Associated ◽

Prosthetic Joint ◽

Observational Cohort

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Gestational Trophoblastic Neoplasia From Genetically Confirmed Hydatidiform Moles: Prospective Observational Cohort Study

International Journal of Gynecological Cancer ◽

10.1097/igc.0000000000001374 ◽

2018 ◽

Vol 28 (9) ◽

pp. 1772-1780 ◽

Cited By ~ 8

Author(s):

Hirokazu Usui ◽

Jia Qu ◽

Asuka Sato ◽

Zijun Pan ◽

Akira Mitsuhashi ◽

...

Keyword(s):

Risk Factors ◽

Cohort Study ◽

Laboratory Data ◽

Spontaneous Remission ◽

Observational Cohort Study ◽

Polymorphism Analysis ◽

Prospective Observational Cohort Study ◽

Gestational Trophoblastic Neoplasia ◽

Observational Cohort ◽

Hydatidiform Moles

ObjectiveThe aim of this study was to evaluate the incidence and risk factors of gestational trophoblastic neoplasia (GTN) from hydatidiform moles (HMs) cytogenetically diagnosed in a prospective cohort setting.MethodsThe prospective observational cohort study included cases of cytogenetically defined molar pregnancies, which were diagnosed by a multiplex short tandem repeat polymorphism analysis. Cases were classified as androgenetic complete HMs (CHMs), diandric monogynic triploid partial HMs (PHMs), or biparental abortion. Gestational trophoblastic neoplasia was diagnosed according to the International Federation of Gynecology and Obstetrics 2000 criteria. Incidences for each category, that is, CHM, PHMs, and biparental abortion, were calculated. Clinical variables (age, partner age, gravidity, parity, height, weight, BMI, and gestational age) and laboratory data (serum human chorionic gonadotropin [hCG], white blood cell count, hemoglobin, and platelet count) were compared between spontaneous remission cases and GTN cases in androgenetic CHMs.ResultsAmong 401 cases, 380 were classified as follows: 232 androgenetic CHMs, 60 diandric monogynic PHMs, and 88 biparental abortions. A total of 35 cases (15.1%) of CHMs, but only 1 case of PHM (1.7%) and no biparental abortions, exhibited progression to GTN. The hCG value before evacuation was significantly higher in GTN cases than in spontaneous remission cases (P = 0.001, Kruskal-Wallis test). Patient age was also significantly higher in GTN cases than in spontaneous remission cases (P = 0.002, Student t test).ConclusionsUnder the cohort cytogenetic diagnosis setting, the traditional risk factors for GTN after molar pregnancy, hCG value before evacuation and age, were confirmed in androgenetic CHMs. The risk of GTN was lower for PHMs than for CHMs. However, 1 patient with cytogenetic PHMs developed into GTN.

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