Calcium Bioavailability and Parathyroid Hormone Acute Changes after Oral Intake of Dairy and Nondairy Products in Healthy Volunteers

Endothelial dysfunction is a potential target for (pharmaceutical) intervention of several systemic pathological conditions. We investigated the feasibility of the EndoPAT to evaluate acute changes in endothelial function with repeated noninvasive measurements and assessed its discriminating power in different populations. Endothelial function was stable over a longer period of time in renally impaired patients (coefficient of variation 13%). Endothelial function in renally impaired and type 2 diabetic patients was not decreased compared to healthy volunteers (2.9±1.4and1.8±0.3, resp., versus1.8±0.5,P>0.05). The EndoPAT did not detect an effect of robust interventions on endothelial function in healthy volunteers (glucose load: change from baseline0.08±0.50, 95% confidence interval −0.44 to 0.60; smoking: change from baseline0.49±0.92, 95% confidence interval −0.47 to 1.46). This suggests that at present the EndoPAT might not be suitable to assess (changes in) endothelial function in early-phase clinical pharmacology studies. Endothelial function as measured by the EndoPAT could be physiologically different from endothelial function as measured by conventional techniques. This should be investigated carefully before the EndoPAT can be considered a useful tool in drug development or clinical practice.

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Pharmacokinetics of 14C-radioactivity after oral intake of a single dose of 14C-labeled fampridine (4-aminopyridine) in healthy volunteers

Clinical Therapeutics ◽

10.1016/j.clinthera.2009.02.004 ◽

2009 ◽

Vol 31 (2) ◽

pp. 328-335 ◽

Cited By ~ 26

Author(s):

Andrew R. Blight ◽

Herbert R. Henney

Keyword(s):

Single Dose ◽

Healthy Volunteers ◽

Oral Intake

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AXT914 a novel, orally-active parathyroid hormone-releasing drug in two early studies of healthy volunteers and postmenopausal women

Bone ◽

10.1016/j.bone.2014.04.015 ◽

2014 ◽

Vol 64 ◽

pp. 204-210 ◽

Cited By ~ 22

Author(s):

Markus R. John ◽

Evita Harfst ◽

Juergen Loeffler ◽

Rossella Belleli ◽

June Mason ◽

...

Keyword(s):

Parathyroid Hormone ◽

Healthy Volunteers ◽

Postmenopausal Women ◽

Orally Active

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Platelet Regeneration Time After Aspirin Ingestion and Platelet Survival Time After Labelling with 51Chromium or 111Indium Oxine – A Comparative Study

Thrombosis and Haemostasis ◽

10.1055/s-0038-1661289 ◽

1985 ◽

Vol 53 (02) ◽

pp. 260-263 ◽

Cited By ~ 3

Author(s):

A Boneu ◽

P Sié ◽

R Bugat ◽

C Caranobe ◽

M Eber ◽

...

Keyword(s):

Healthy Volunteers ◽

Survival Time ◽

Oral Intake ◽

Weighted Mean ◽

Regeneration Time ◽

Platelet Survival ◽

The Mean ◽

Multiple Hit ◽

Aspirin Ingestion

SummaryA simultaneous investigation of platelet regeneration time (PRT) based upon malondialdehyde (MDA) recovery after a single oral intake of 500 mg of aspirin and of platelet survival time (PST) after labelling with 51chromium or 111Inindium oxine was performed in 25 cancerous patients. A pilot study conducted with 9 healthy volunteers demonstrated that the MDA assay was highly reproducible and specific for the platelet cycloxygenase activity. The pattern of MDA recovery after aspirin ingestion was linear in the healthy volunteers and in the patients presenting both a normal and an accelerated platelet turnover. PST were calculated using the four mathematical models recommended by the International Committee for Standardization in Hematology; the best fit was given by the multiple hit model in 22 cases and by the linear regression model in 3 cases. The mean results obtained in the patients investigated with the 51chromium were consistently shorter than those obtained in the patients investigated with the mindium oxine while the mean PRT were almost identical in the two groups. An excellent correlation between PRT and PST was observed after 111Indium oxine labelling and using the weighted mean method for PST determination. These results suggest that the 111Indium oxine technique is a better method for platelet labelling and that the results provided by the weighted mean method reflect more closely the in vivo platelet turnover than those provided by the multiple hit model.

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Different elemental infant formulas show equivalent phosphorus and calcium bioavailability in healthy volunteers

Nutrition Research ◽

10.1016/j.nutres.2020.11.004 ◽

2020 ◽

Author(s):

Clemens Bergwitz ◽

Simone R.B.M. Eussen ◽

Pilou L.H.R. Janssens ◽

Monique Visser ◽

Thomas O. Carpenter ◽

...

Keyword(s):

Healthy Volunteers ◽

Infant Formulas ◽

Calcium Bioavailability

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Nonradioactive Semi-Automated Determination of Platelet Survival Time in Man

10.1055/s-0039-1680558 ◽

1977 ◽

Author(s):

R. Roncucci ◽

R. Deperon ◽

J. Lansen ◽

J. Destailleur ◽

R. Verhaeghe ◽

...

Keyword(s):

Acetylsalicylic Acid ◽

Life Span ◽

Healthy Volunteers ◽

Survival Time ◽

Ex Vivo ◽

Oral Intake ◽

Platelet Survival ◽

Ex Vivo Assay ◽

Automated Determination

Several methods have been proposed for the determination of platelet life-span. Among them the technique described by Stuart and al (l) based upon the ex-vivo assay of platelet malondialdehyde after one single oral intake of acetylsalicylic acid is receiving an increasing interest. We adapted this method for semi-automated determinations using an AutoAnalyzer system.Platelet survival time was determined with this technique in healthy volunteers as well as in patients with abnormal platelet life-span.In some instances chromium-51-determinations were also performed in order to assess the reliability of the method proposed. The results obtained are comparable for both methods and compatible with those described in the literature.

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