Gene expression profiles in the brain of the neonate mouse perinatally exposed to methylmercury and/or polychlorinated biphenyls

2009 ◽  
Vol 84 (4) ◽  
pp. 271-286 ◽  
Author(s):  
Miyuki Shimada ◽  
Satomi Kameo ◽  
Norio Sugawara ◽  
Kozue Yaginuma-Sakurai ◽  
Naoyuki Kurokawa ◽  
...  
Keyword(s):  
Gene Expression ◽  
Polychlorinated Biphenyls ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
The Brain

Influenza virus-induced sleep responses in mice with targeted disruptions in neuronal or inducible nitric oxide synthases

2004 ◽  
Vol 97 (1) ◽  
pp. 17-28 ◽  
Author(s):  
Lichao Chen ◽  
Deborah Duricka ◽  
Scott Nelson ◽  
Sanjib Mukherjee ◽  
Stewart G. Bohnet ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nitric Oxide ◽  
Eye Movement ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
No Synthase ◽  
Cytokine Gene Expression ◽  
Rapid Eye Movement ◽  
Rapid Eye Movement Sleep ◽  
The Brain

Influenza viral infection induces increases in non-rapid eye movement sleep and decreases in rapid eye movement sleep in normal mice. An array of cytokines is produced during the infection, and some of them, such as IL-1β and TNF-α, are well-defined somnogenic substances. It is suggested that nitric oxide (NO) may mediate the sleep-promoting effects of these cytokines. In this study, we use mice with targeted disruptions of either the neuronal NO synthase (nNOS) or the inducible NO synthase (iNOS) gene, commonly referred to as nNOS or iNOS knockouts (KOs), to investigate sleep changes after influenza viral challenge. We report that the magnitude of viral-induced non-rapid eye movement sleep responses in both nNOS KOs and iNOS KOs was less than that of their respective controls. In addition, the duration of rapid eye movement sleep in nNOS KO mice did not decrease compared with baseline values. All strains of mice had similar viral titers and cytokine gene expression profiles in the lungs. Virus was not isolated from the brains of any strain. However, gene expression in the brain stem differed between nNOS KOs and their controls: mRNA for the interferon-induced gene 2′,5′-oligoadenylate synthase 1a was elevated in nNOS KOs relative to their controls at 15 h, and IL-1β mRNA was elevated in nNOS KOs relative to their controls at 48 h. Our results suggest that NO synthesized by both nNOS and iNOS plays a role in virus-induced sleep changes and that nNOS may modulate cytokine expression in the brain.

Effect of pharmacologic resuscitation on the brain gene expression profiles in a swine model of traumatic brain injury and hemorrhage

2014 ◽  
Vol 77 (6) ◽  
pp. 906-912 ◽  
Author(s):  
Simone E. Dekker ◽  
Ted Bambakidis ◽  
Martin Sillesen ◽  
Baoling Liu ◽  
Craig N. Johnson ◽  
...  
Keyword(s):  
Gene Expression ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Swine Model ◽  
Brain Gene Expression ◽  
The Brain

scholarly journals Analysis of genes causing hypertension and stroke in spontaneously hypertensive rats: Gene expression profiles in the brain

2014 ◽  
Vol 33 (4) ◽  
pp. 887-896 ◽  
Author(s):  
MOMOKO YOSHIDA ◽  
YUKO WATANABE ◽  
KYOSUKE YAMANISHI ◽  
AKIFUMI YAMASHITA ◽  
HIDEYUKI YAMAMOTO ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spontaneously Hypertensive Rats ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
The Brain

scholarly journals Altered Gene Expression Profiles in the Brain, Kidney, and Lung of One-Month-Old Cloned Pigs

2011 ◽  
Vol 13 (3) ◽  
pp. 215-223 ◽  
Author(s):  
Joonghoon Park ◽  
Liangxue Lai ◽  
Melissa Samuel ◽  
David Wax ◽  
Richard S. Bruno ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Altered Gene Expression ◽  
Altered Gene ◽  
The Brain

Transgenerational effects of polychlorinated biphenyls: 2. Hypothalamic gene expression in rats

2021 ◽  
Author(s):  
Andrea C Gore ◽  
Lindsay M Thompson ◽  
Mandee Bell ◽  
Jan A Mennigen
Keyword(s):  
Gene Expression ◽  
Polychlorinated Biphenyls ◽  
Expression Profiles ◽  
Endocrine Disrupting Chemicals ◽  
Gene Expression Profiles ◽  
Estradiol Benzoate ◽  
Dependent Manner ◽  
Sprague Dawley ◽  
Transgenerational Effects ◽  
Aroclor 1221

Abstract Polychlorinated biphenyls (PCBs) are endocrine-disrupting chemicals (EDCs) with well-established effects on reproduction and behavior in developmentally-exposed (F1) individuals. Because of evidence for transgenerational effects of EDCs on the neuroendocrine control of reproductive physiology, we tested the hypothesis that prenatal PCB exposure leads to unique hypothalamic gene expression profiles in three generations. Pregnant Sprague–Dawley rats were treated on gestational days 16 and 18 with the PCB mixture Aroclor 1221 (A1221), vehicle (3% DMSO in sesame oil), or estradiol benzoate (EB, 50 μg/kg), the latter a positive control for estrogenic effects of A1221. Maternal- and paternal-lineage F2 and F3 generations were bred using untreated partners. The anteroventral periventricular nucleus (AVPV) and arcuate nucleus (ARC), involved in the hypothalamic control of reproduction, were dissected from F1-F3 females and males, RNA extracted, and gene expression measured in a qPCR array. We detected unique gene expression profiles in each generation, that were sex- and lineage-specific. In the AVPV, treatment significantly changed 10, 25, and 11 transcripts in F1, F2, and F3 generations, whereas 10, 1, and 12 transcripts were changed in these generations in the ARC. In the F1 AVPV and ARC, most affected transcripts were decreased by A1221. In the F2 AVPV, most effects of A1221 were observed in females of the maternal lineage, whereas only Pomc expression changed in the F2 ARC (by EB). The F3 AVPV and ARC were mainly affected by EB. It is notable that results in one generation do not predict results in another, and that lineage was a major determinant in results. Thus, transient prenatal exposure of F1 rats to A1221 or EB can alter hypothalamic gene expression across 3 generations in a sex- and lineage-dependent manner, leading to the conclusion that the legacy of PCBs continues for generations.

scholarly journals Probabilistic Critical Controllability Analysis of Protein Interaction Networks Integrating Normal Brain Ageing Gene Expression Profiles

2021 ◽  
Vol 22 (18) ◽  
pp. 9891
Author(s):  
Eimi Yamaguchi ◽  
Tatsuya Akutsu ◽  
Jose C. Nacher
Keyword(s):  
Gene Expression ◽  
Biological Networks ◽  
Expression Profiles ◽  
Dominating Set ◽  
Gene Expression Profiles ◽  
Brain Regions ◽  
Normal Brain ◽  
Age Related ◽  
Brain Ageing ◽  
The Brain

Recently, network controllability studies have proposed several frameworks for the control of large complex biological networks using a small number of life molecules. However, age-related changes in the brain have not been investigated from a controllability perspective. In this study, we compiled the gene expression profiles of four normal brain regions from individuals aged 20–99 years and generated dynamic probabilistic protein networks across their lifespan. We developed a new algorithm that efficiently identified critical proteins in probabilistic complex networks, in the context of a minimum dominating set controllability model. The results showed that the identified critical proteins were significantly enriched with well-known ageing genes collected from the GenAge database. In particular, the enrichment observed in replicative and premature senescence biological processes with critical proteins for male samples in the hippocampal region led to the identification of possible new ageing gene candidates.

Gene expression profiles of breast and lung metastases to the brain.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. e12503-e12503
Author(s):  
D. Dréau ◽  
J. M. Eddy ◽  
K. Thompson ◽  
J. Weller ◽  
J. Dollar ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Metastases ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
The Brain

scholarly journals Distribution of Kakugo Virus and Its Effects on the Gene Expression Profile in the Brain of the Worker Honeybee Apis mellifera L.

2009 ◽  
Vol 83 (22) ◽  
pp. 11560-11568 ◽  
Author(s):  
Tomoko Fujiyuki ◽  
Emiko Matsuzaka ◽  
Takayoshi Nakaoka ◽  
Hideaki Takeuchi ◽  
Akiko Wakamoto ◽  
...  
Keyword(s):  
Gene Expression ◽  
Leucine Zipper ◽  
Expression Profiles ◽  
Parasitic Wasp ◽  
Gene Expression Profiles ◽  
Hypothetical Protein ◽  
Brain Regions ◽  
Gene Encoding ◽  
Brain Functions ◽  
The Brain

ABSTRACT We previously identified a novel insect picorna-like virus, termed Kakugo virus (KV), obtained from the brains of aggressive honeybee worker bees that had counterattacked giant hornets. Here we examined the tissue distribution of KV and alterations of gene expression profiles in the brains of KV-infected worker bees to analyze possible effects of KV infection on honeybee neural and physiological states. By use of in situ hybridization, KV was broadly detected in the brains of the naturally KV-infected worker bees. When inoculated experimentally into bees, KV was detected in restricted parts of the brain at the early infectious stage and was later detected in various brain regions, including the mushroom bodies, optic lobes, and ocellar nerve. KV was detected not only in the brain but also in the hypopharyngeal glands and fat bodies, indicating systemic KV infection. Next, we compared the gene expression profiles in the brains of KV-inoculated and noninoculated bees. The expression of 11 genes examined was not significantly affected in KV-infected worker bees. cDNA microarray analysis, however, identified a novel gene whose expression was induced in the periphery of the brains of KV-infected bees, which was commonly observed in naturally infected and experimentally inoculated bees. The gene encoded a novel hypothetical protein with a leucine zipper motif. A gene encoding a similar protein was found in the parasitic wasp Nasonia genome but not in other insect genomes. These findings suggest that KV infection may affect brain functions and/or physiological states in honeybees.

Alteration of gene expression profiles in the brain of Japanese medaka (Oryzias latipes) exposed to KC-400 or PCB126

2008 ◽  
Vol 57 (6-12) ◽  
pp. 460-466 ◽  
Author(s):  
Kei Nakayama ◽  
Naomi Sei ◽  
Yuji Oshima ◽  
Kosuke Tashiro ◽  
Yohei Shimasaki ◽  
...  
Keyword(s):  
Gene Expression ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Oryzias Latipes ◽  
Japanese Medaka ◽  
The Brain
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