Cardioprotective effect of pioglitazone and curcumin against diabetic cardiomyopathy in type 1 diabetes mellitus: impact on CaMKII/NF-κB/TGF-β1 and PPAR-γ signaling pathway

2020 ◽  
Author(s):  
Aya A. Gbr ◽  
Nayira A. Abdel Baky ◽  
Eman A. Mohamed ◽  
Heba S. Zaky
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Signaling Pathway ◽  
Diabetic Cardiomyopathy ◽  
Cardioprotective Effect ◽  
Ppar Γ ◽  
Tgf Β1

Polymorphisms in the Genes Encoding TGF-β1, TNF-α, and IL-6 Show Association with Type 1 Diabetes Mellitus in the Slovak Population

2010 ◽  
Vol 58 (5) ◽  
pp. 385-393 ◽  
Author(s):  
Juraj Javor ◽  
Stanislav Ferencik ◽  
Maria Bucova ◽  
Martina Stuchlikova ◽  
Emil Martinka ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Slovak Population ◽  
Tnf Α ◽  
Genes Encoding ◽  
Tgf Β1

scholarly journals Analysis of circRNA regulatory network in myocardial tissue of type 1 diabetic mice

2021 ◽  
Vol 67 (3) ◽  
pp. 201-203
Author(s):  
Jianjun Li ◽  
Xiaoxiao Li ◽  
Xiaoming Qiao
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Diabetic Cardiomyopathy ◽  
Heart Function ◽  
Control Group ◽  
Diabetic Patients ◽  
Myocardial Tissue ◽  
Regulation Network

Type 1 diabetes mellitus, also called insulin-dependent diabetes is associated with elevated blood glucose concentration arising from the inability of the pancreas to produce insulin. Diabetic cardiomyopathy is a major cause of death in diabetic patients. CircRNAs have been reported to participate in various human diseases, including diabetic cardiomyopathy. In this study, the regulation network of circRNA in type 1 diabetes mellitus was investigated. Streptozotocin treatment was implemented to induce type 1 diabetes mellitus in the mouse model, and echocardiography was implemented to detect the heart function of the type 1 diabetes mellitus mouse. Also, the qRT-PCR assay was used to identify the circRNA expression in type 1 diabetes mellitus mouse myocardial tissue. Findings showed that heart function of type 1 diabetes mellitus mouse was significantly damaged than control group mouse and cardiac hypertrophy in type 1 diabetes mellitus mouse, circRNAs were aberrantly regulated in type 1 diabetes mellitus mouse myocardial tissue. The following circRNAs were mmu_circ_0001560, mmu_circ_0001800, mmu_circ_0001801, mmu_circ_0002281 and mmu_circ_0000614 were expressed low in type 1 diabetes mellitus mouse myocardial tissue. In conclusion, type 1 diabetes mellitus caused alterations in the regulation network of circRNAs.

scholarly journals Can We Prevent Mitochondrial Dysfunction and Diabetic Cardiomyopathy in Type 1 Diabetes Mellitus? Pathophysiology and Treatment Options

2020 ◽  
Vol 21 (8) ◽  
pp. 2852
Author(s):  
Aleksandra Cieluch ◽  
Aleksandra Uruska ◽  
Dorota Zozulinska-Ziolkiewicz
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Mitochondrial Dysfunction ◽  
Type 1 Diabetes Mellitus ◽  
Diabetic Cardiomyopathy ◽  
Treatment Options ◽  
Therapeutic Approaches ◽  
Stress Studies ◽  
Chronic Hyperglycemia

Type 1 diabetes mellitus is a disease involving changes to energy metabolism. Chronic hyperglycemia is a major cause of diabetes complications. Hyperglycemia induces mechanisms that generate the excessive production of reactive oxygen species, leading to the development of oxidative stress. Studies with animal models have indicated the involvement of mitochondrial dysfunction in the pathogenesis of diabetic cardiomyopathy. In the current review, we aimed to collect scientific reports linking disorders in mitochondrial functioning with the development of diabetic cardiomyopathy in type 1 diabetes mellitus. We also aimed to present therapeutic approaches counteracting the development of mitochondrial dysfunction and diabetic cardiomyopathy in type 1 diabetes mellitus.

A proinsulin74-90 -derived protease-resistant, altered peptide ligand increases TGF-β1 secretion in PBMC from patients with type 1 diabetes mellitus

2010 ◽  
Vol 87 (5) ◽  
pp. 943-948 ◽  
Author(s):  
Denise van Aalst ◽  
Hubert Kalbacher ◽  
David Palesch ◽  
Fang Zou ◽  
Andreas Spyrantis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Peptide Ligand ◽  
Altered Peptide Ligand ◽  
Tgf Β1
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